Current Advances in Drug Delivery Through Fast Dissolving/Disintegrating Dosage Forms

Singh, Anupama; Jindal, Arpita; Mishra, Deepak; Jadhav, Hemant R.; Nagpal, Kalpana; Singh, Mahaveer; Mathur, Prashant; Singh, Shailendra Kumar; Kumar, Sokindra; Kharb, Vandana; Saharan, Vikas Anand

doi:10.2174/97816810845961170101

Cited by 5 publications

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“…Thus, highly porous tablets can be manufactured using a freeze-drying (lyophilization) method [3]. A major problem for tablets manufactured by lyophilization is low hardness and high friability [4]. Issues of low hardness and high friability can be overcome by formulating conventional tablets.…”

Section: Introductionmentioning

confidence: 99%

Development of a multiple-unit system: Tablets containing amlodipine besylate which have different release kinetics

Tekdemir¹,

Tilki²,

Uğurlu³

2020

jrp

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Multiple-unit systems may include tablets, capsules, pellets in a single administration. Once-a-day administration of Amlodipine Besylate (AML) accounts for fluctuation of plasma drug concentrations between dosing intervals. The aim of this study is to develop an extended-release (ER) and an immediate-release (IR) tablet to overcome the fluctuation of plasma drug concentrations. To achieve this purpose, 9 IR tablets and 6 ER tablet formulations were developed. The dissolution media for IR tablets was pH 2 for 1 hour and the dissolution media for ER tablets was pH 2 for 2 hours, and afterwards was pH 6.8 for 10 hours. The amount of AML released into the dissolution media was measured by Mettler Toledo UV 5 at a wavelength of 238 nm. The dissolution data of IR and ER tablets were statically evaluated. The highest dissolution rate for IR tablets (93%) was achieved with the IR-5 formulation. For ER tablets, a 50% drug release was achieved with the ER-1 and ER-4 formulation. The drug release kinetics of all ER tablets were calculated and subsequently the ER-1 formulation, which has Higuchi drug release kinetics, was chosen as the ER tablet. Lastly, a dissolution study of the selected formulations (IR-5 and ER-1) was conducted in the same vessel. After 12 hours of the dissolution study, drug release was found to be 79% ±0,92 (close to 75% which was targeted). Multiple-unit systems that have different tablet formulations in one administration could be used to enhance drug release kinetics that cannot be achieved with conventional tablets.

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Section: Introductionmentioning

confidence: 99%