Current applications of nanoparticles in infectious diseases

Gómez, Hinojal Zazo; Colino, Clara I.; Lanao, José M.

doi:10.1016/j.jconrel.2016.01.008

Cited by 366 publications

(246 citation statements)

References 256 publications

Supporting

Mentioning

241

Contrasting

Unclassified

Order By: Relevance

“…These nano-carriers include but not limited to liposomes, solid lipid nanoparticles, polymeric nanoparticles, metal nanoparticles, quantum dots and self-assembled micelles [9–12]. An extensive evaluation for the pros and cons of each of those nano-carriers for combatting microbial resistance has recently been reviewed [4, 5, 11–14]. Reader is strongly advised to refer/read those reviews for detailed discussions related to the improvement in the antibacterial activity of each of those nano-carrier delivery systems against various pathogenic microbes [11, 12].…”

Section: Introductionmentioning

confidence: 99%

Imipenem/cilastatin encapsulated polymeric nanoparticles for destroying carbapenem-resistant bacterial isolates

2017

View full text Add to dashboard Cite

BackgroundCarbapenem-resistance is an extremely growing medical threat in antibacterial therapy as the incurable resistant strains easily develop a multi-resistance action to other potent antimicrobial agents. Nonetheless, the protective delivery of current antibiotics using nano-carriers opens a tremendous approach in the antimicrobial therapy, allowing the nano-formulated antibiotics to beat these health threat pathogens. Herein, we encapsulated imipenem into biodegradable polymeric nanoparticles to destroy the imipenem-resistant bacteria and overcome the microbial adhesion and dissemination. Imipenem loaded poly Ɛ-caprolactone (PCL) and polylactide-co-glycolide (PLGA) nanocapsules were formulated using double emulsion evaporation method. The obtained nanocapsules were characterized for mean particle diameter, morphology, loading efficiency, and in vitro release. The in vitro antimicrobial and anti adhesion activities were evaluated against selected imipenem-resistant Klebsiella pneumoniae and Pseudomonas aeruginosa clinical isolates.ResultsThe obtained results reveal that imipenem loaded PCL nano-formulation enhances the microbial susceptibility and antimicrobial activity of imipenem. The imipenem loaded PCL nanoparticles caused faster microbial killing within 2–3 h compared to the imipenem loaded PLGA and free drug. Successfully, PCL nanocapsules were able to protect imipenem from enzymatic degradation by resistant isolates and prevent the emergence of the resistant colonies, as it lowered the mutation prevention concentration of free imipenem by twofolds. Moreover, the imipenem loaded PCL eliminated bacterial attachment and the biofilm assembly of P. aeruginosa and K. pneumoniae planktonic bacteria by 74 and 78.4%, respectively.ConclusionsThese promising results indicate that polymeric nanoparticles recover the efficacy of imipenem and can be considered as a new paradigm shift against multidrug-resistant isolates in treating severe bacterial infections.

show abstract

Section: Introductionmentioning

confidence: 99%

Imipenem/cilastatin encapsulated polymeric nanoparticles for destroying carbapenem-resistant bacterial isolates

2017

View full text Add to dashboard Cite

show abstract

“…As a promising alternative to the current antibiotic-based method, nanomaterial-based antimicrobials provide a new paradigm for conquering antibiotic-resistant pathogens. [12][13][14] Among subcellular organelles, the intracellular mitochondrion has been found to be the main target for the accumulation and cytotoxicity of vanadium species in biological systems. [15][16][17] On the basis of endosymbiotic theory, a bacterium is the analogue of the mitochondrion of a mammalian cell.…”

Section: Introductionmentioning

confidence: 99%

A functionalized surface modification with vanadium nanoparticles of various valences against implant-associated bloodstream infection

Wang¹,

Zhou²,

Guo³

et al. 2017

IJN

View full text Add to dashboard Cite

Bloodstream infection, especially with implants involved, is an often life-threatening condition with high mortality rates, imposing a heavy burden on patients and medical systems. Herein, we firstly deposited homogeneous vanadium metal, V 2 O 3 , VO 2 , and V 2 O 5 nanofilms on quartz glass by magnetron sputtering. Using these platforms, we further investigated the potential antimicrobial efficiency of these nano-VO x films and the interactions of human erythrocytes and bacteria (methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa ) with our samples in a novel cell–bacteria coculture model. It was demonstrated that these nano-VO x precipitated favorable antibacterial activity on both bacteria, especially on S. aureus , and this effect increased with higher vanadium valence. A possible mechanism accountable for these results might be elevated levels of vanadium-induced intracellular reactive oxygen species. More importantly, based on hemolysis assays, our nano-VO x films were found to be able to kill prokaryotic cells but were not toxic to mammalian cells, holding the potential for the prevention of implant-related hematogenous infections. As far as we know, this is the first report wherein such nano-VO x films have assisted human erythrocytes to combat bacteria in a valence-dependent manner. Additionally, vanadium ions were released from these nano-VO x films in a sustained manner, and low-valence films possessed better biocompatibility with human fibroblasts. This work may provide new insights for biomedical applications of inorganic vanadium compounds and attract growing attention in this field. From the perspective of surface modification and functionalization, this study holds promise to avail the prophylaxis of bloodstream infections involving implantable biomedical devices.

show abstract

“…In particular, such NPs may be designed to transport to the site of disease the cargo that is hydrophobic [1][2][3] .…”

mentioning

confidence: 99%

Two-Photon Induced Fluorescence Energy Transfer in Polymeric Nanocapsules Containing CdSe_xS_1–x/ZnS Core/Shell Quantum Dots and Zinc(II) Phthalocyanine

et al. 2016

View full text Add to dashboard Cite

We report activation of a photodynamic therapy photosensitizer, zinc phthalocyanine, by Förster resonant energy transfer (FRET) from two-photon absorption excited CdSe x S 1-x /ZnS quantum dots coencapsulated in multifunctional biocompatible polymer nanocapsules.Polymer nanocapsules (100 nm size) were prepared via solvent/evaporation method using Poloxamer 403 as the polymer component, Cremophor EL ® as the surfactant and mixture of silicone oil with hydrogenated caprylyl olive oil esters as the oil phase. UV-VIS-NIR absorption and multiphoton fluorescence studies confirmed successful coencapsulation of both components of the FRET system. The energy transfer between the quantum dots as donors and Zn phthalocyanine molecules as acceptors was studied using steady-state photoluminescence and time-correlated single photon counting techniques. The changes in the lifetime of the QDs emission indicate that the excitation of ZnPc occurs not only through reabsorption but also through FRET. The generation of the reactive oxygen species was confirmed by formation of non-fluorescent endoperoxide -derivative of fluorescent 9,10-anthracenediyl-bis(methylene)dimalonic acid sodium salt under irradiation of the nanocapsules co-loaded with both QDs and ZnPc.

show abstract

Current applications of nanoparticles in infectious diseases

Cited by 366 publications

References 256 publications

Imipenem/cilastatin encapsulated polymeric nanoparticles for destroying carbapenem-resistant bacterial isolates

Imipenem/cilastatin encapsulated polymeric nanoparticles for destroying carbapenem-resistant bacterial isolates

A functionalized surface modification with vanadium nanoparticles of various valences against implant-associated bloodstream infection

Two-Photon Induced Fluorescence Energy Transfer in Polymeric Nanocapsules Containing CdSe_xS_1–x/ZnS Core/Shell Quantum Dots and Zinc(II) Phthalocyanine

Contact Info

Product

Resources

About

Current applications of nanoparticles in infectious diseases

Cited by 366 publications

References 256 publications

Imipenem/cilastatin encapsulated polymeric nanoparticles for destroying carbapenem-resistant bacterial isolates

Imipenem/cilastatin encapsulated polymeric nanoparticles for destroying carbapenem-resistant bacterial isolates

A functionalized surface modification with vanadium nanoparticles of various valences against implant-associated bloodstream infection

Two-Photon Induced Fluorescence Energy Transfer in Polymeric Nanocapsules Containing CdSexS1–x/ZnS Core/Shell Quantum Dots and Zinc(II) Phthalocyanine

Contact Info

Product

Resources

About

Two-Photon Induced Fluorescence Energy Transfer in Polymeric Nanocapsules Containing CdSe_xS_1–x/ZnS Core/Shell Quantum Dots and Zinc(II) Phthalocyanine