Current Approaches on Viral Infection: Proteomics and Functional Validations

Zheng, Jie; Tan, Boon Huan; Sugrue, Richard J.; Tang, Kai

doi:10.3389/fmicb.2012.00393

Cited by 8 publications

(4 citation statements)

References 123 publications

(128 reference statements)

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“…Though characterization of Glycoproteins is tough but, through Mass Spectrometry, it is now easier to identify structural details of complex glycoproteins. Mass spectrometry derived glycoproteomics [ 118 ] helps us to precisely identify viral and cellular proteins that are functionally, structurally, and dynamically altered during virus infection, but enables us to identify important proteins having active role in the infection pathway. Additionally, isolation and purification techniques along with quantitative strategies in conjunction with MS significantly improve its sensitivity to detect low-abundant proteins.…”

Section: Viral Glycoproteinsmentioning

confidence: 99%

Viral glycoproteins: biological role and application in diagnosis

Banerjee¹,

Mukhopadhyay²

2016

VirusDis.

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The viruses that infect humans cause a huge global disease burden and produce immense challenge towards healthcare system. Glycoproteins are one of the major components of human pathogenic viruses. They have been demonstrated to have important role(s) in infection and immunity. Concomitantly high titres of antibodies against these antigenic viral glycoproteins have paved the way for development of novel diagnostics. Availability of appropriate biomarkers is necessary for advance diagnosis of infectious diseases especially in case of outbreaks. As human mobilization has increased manifold nowadays, dissemination of infectious agents became quicker that paves the need of rapid diagnostic system. In case of viral infection it is an emergency as virus spreads and mutates very fast. This review encircles the vast arena of viral glycoproteins, their importance in health and disease and their diagnostic applications.

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Section: Viral Glycoproteinsmentioning

confidence: 99%

Viral glycoproteins: biological role and application in diagnosis

Banerjee¹,

Mukhopadhyay²

2016

VirusDis.

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“…It requires finding and categorizing the various host factors which could be involved actively in the cycle of virus infection. Moreover, there is also a need to categorize the identified host responses into a qualitative and a quantitative category through viral pathogenesis (Zheng et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Omics Approaches in Viral Biotechnology

Waqar

Irfan

Gul

2018

Omics Technologies and Bio-Engineering

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“…Advances in analytical techniques to explore global proteome changes have found increasing use in host-pathogen interaction studies in infections [1,2]. Conventional gel-based systems for the purpose use a two-dimensional protein electrophoresis followed by protein identification by mass spectrometry.…”

Section: Introductionmentioning

confidence: 99%

High throughput proteomic analysis and a comparative review identify the nuclear chaperone, Nucleophosmin among the common set of proteins modulated in Chikungunya virus infection

Abraham

Mudaliar

Jaleel

et al. 2015

Journal of Proteomics

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Chikungunya remained as a neglected tropical disease till its re-emergence in 2005 in the La RéUnion islands and subsequently, in India and many parts of South East Asia. These and the epidemics that followed in subsequent years ran an explosive course leading to extreme morbidity and attributed mortality to this originally benign virus infection. Apart from classical symptoms of acute fever and debilitating polyarthralgia lasting for several weeks, a number of complications were documented. These included aphthous-like ulcers and vesiculo-bullous eruptions on the skin, hepatic involvement, central nervous system complications such as encephalopathy and encephalitis, and transplacental transmission. The disease has recently spread to the Americas with its initial documentation in the Caribbean islands. The Asian genotype of this positive-stranded RNA virus of the Alphavirus genus has been attributed in these outbreaks. However, the disease ran a similar course as the one caused by the East, Central and South African (ECSA) genotype in the other parts of the world. Studies have documented a number of mutations in the re-emerging strains of the virus that enhances mosquito adaptability and modulates virus infectivity. This might support the occurrence of fiery outbreaks in the absence of herd immunity in affected population. Several research groups work to understand the pathogenesis of chikungunya and the mechanisms of complications using cellular and animal models. A few proteomics approaches have been employed earlier to understand the protein level changes in the infected cells. Our present study, which couples a high throughput proteomic analysis and a comparative review of these earlier studies, identifies a few critical molecules as hypothetical candidates that might be important in this infection and for future study.

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Current Approaches on Viral Infection: Proteomics and Functional Validations

Cited by 8 publications

References 123 publications

Viral glycoproteins: biological role and application in diagnosis

Viral glycoproteins: biological role and application in diagnosis

Omics Approaches in Viral Biotechnology

High throughput proteomic analysis and a comparative review identify the nuclear chaperone, Nucleophosmin among the common set of proteins modulated in Chikungunya virus infection

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