Current Challenges and Innovative Developments in Hydroxyapatite-Based Coatings on Metallic Materials for Bone Implantation: A Review

Beig, Bilal; Liaqat, Usman; Niazi, Muhammad Farooq Khan; Douna, Inamullah; Zahoor, Muhammad Kashif; Niazi, Muhammad Bilal Khan

doi:10.3390/coatings10121249

Cited by 76 publications

(44 citation statements)

References 209 publications

(162 reference statements)

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“…Besides, low molecular strength, poor flexibility, and fragile nature sometimes hamper its direct applicability, which is generally revised with innovative methods. 88 Regardless of the multi-directional applications of the eggshell membrane in various tissue engineering fields, the eggshell membrane is often hard to dissolve in an aqueous solution because of certain internal interactions, and also the temperature associated with the processing is crucial to avoid denaturation of collagens and other fibrous proteins (50–70 °C). 89 Moreover, the eggshell membrane is also very much prone to bacterial and fungal contamination if handled inappropriately.…”

Section: Naturally Derived Materials From Agricultural Wastes As Raw Materials For Biomedical Applicationsmentioning

confidence: 99%

Waste-derived biomaterials as building blocks in the biomedical field

et al. 2022

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Section: Naturally Derived Materials From Agricultural Wastes As Raw Materials For Biomedical Applicationsmentioning

confidence: 99%

Waste-derived biomaterials as building blocks in the biomedical field

et al. 2022

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“…The biggest advantage of using them as a bioceramic or biomaterial compared to other materials, such as bioglass or glass–ceramic, is their chemical similarity to the inorganic component of the bone tissue. For example, synthetic hydroxyapatite has been applied clinically both as a dense, sintered cement and as a coating on metallic implants [ 2 , 3 ]. Nowadays, researchers are still developing many new areas of using the nanometric hydroxyapatite in orthopedics for drug release and bio-imaging [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Multifunctionality of Nanosized Calcium Apatite Dual-Doped with Li+/Eu3+ Ions Related to Cell Culture Studies and Cytotoxicity Evaluation In Vitro

et al. 2021

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Li+/Eu3+ dual-doped calcium apatite analogues were fabricated using a microwave stimulated hydrothermal technique. XRPD, FT-IR, micro-Raman spectroscopy, TEM and SAED measurements indicated that obtained apatites are single-phased, crystallize with a hexagonal structure, have similar morphology and nanometric size as well as show red luminescence. Lithium effectively modifies the local symmetry of optical active sites and, thus, affects the emission efficiency. Moreover, the hydrodynamic size and surface charge of the nanoparticles have been extensively studied. The protein adsorption (lysozyme, LSZ; bovine serum albumin, BSA) on the nanoparticle surface depended on the type of cationic dopant (Li+, Eu3+) and anionic group (OH−, Cl−, F−) of the apatite matrix. Interaction with LSZ resulted in a positive zeta potential, and the nanoparticles had the lowest hydrodynamic size in this protein medium. The cytotoxicity assessment was carried out on the human osteosarcoma cell line (U2OS), murine macrophages (J774.E), as well as human red blood cells (RBCs). The studied apatites were not cytotoxic to RBCs and J774.E cells; however, at higher concentrations of nanoparticles, cytotoxicity was observed against the U2OS cell line. No antimicrobial activity was detected against Gram-negative bacteria with one exception for P. aeruginosa treated with Li+-doped fluorapatite.

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“…На закінчення треба зазначити, що завдяки своїй хімічній структурі, схожою зі структурою натуральної Огляд / Review кістки, поряд із його біоактивністю, остеокондуктивністю й остеоіндуктивністю, ГАП успішно застосовується в композитах, що біодеградують, на основі полімерів і металевих біоматеріалів [9,48].…”

Section: проблеми застосування композиційних імплантів що біодеградують під час лікування переломівunclassified

Проблема Використання Композитних Імплантів, Що Біодеградують, У Лікуванні Переломів Кісток (Огляд Літератури)

Павлов¹,

Pastukh²,

Karpinsky³

2021

TRAUMA

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Diseases and injuries of the musculoskeletal system rank second among the causes of injuries and third among the diseases that lead to disability of the adult population. Orthopedic implants have a special place in both clinical practice and the biomedical industry. The implants capable of biodegrading in the case of their implantation into the human body are of the greatest interest. The concept of biodegra-dable implants appeared through the formation and development of the use of suture materials that are absorbed in the body. Subsequently, this type of material began to be used in the treatment of fractures, because in many cases, bone fragments need only temporary support with a fixator, until they fuse. Implantable internal fixation devices for fracture repair using polyglycolic acid (PGA), polylactic acid (PLA), and a copolymer of lactic acid and glycolide (PLGA) became popular. However, the mechanical properties of highly porous skeletons were relatively weak compared to those required for bone engineering. In the process of creating an optimal polymeric biodegradable material, it is necessary to overcome the contradiction between strength and biodegradation. PGA, providing high strength of fixation, degrade too quickly, and PLGA, having high crystallinity, slightly degrade, at the same time conceding on the durability of both PGA and biostable materials. Scientists are now working hard to develop composites from calcium phosphate and polymer, in particular hydroxyapatite and tricalсium phosphate (TCP). TCP with three polymorphic modifications, in particular α-TCP, β-TCP, and α'-TCP, is a well-known bioceramic substance for bone repair. β-TKP is attracting increasing attention due to its excellent biocompatibility, bioactivity, and biodegradability. The composite materials based on bioactive ceramics mainly refer to materials with additional advantages, such as biodegradable polymers and ceramics. At the same time, these composites are biocompatible, osteoconductive, mechanical strength and have osteogenic characteristics. At the same time, thanks to new manufacturing technologies that have emerged in recent years, these compo-site materials are the most promising in the field of bone defect repair. The treatment of fractures with implants is increasingly associated with composite materials. Biomaterials must have certain mechanical properties: biocompatibility, biodegradation, controlled rate biodegradation, good mechanical strength, and bioactivity. Biomaterials used in the treatment of bone fractures have to disintegrate over time, and the addition of nanofillers can slow down the rate of decay of the biodegradable composite.

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Current Challenges and Innovative Developments in Hydroxyapatite-Based Coatings on Metallic Materials for Bone Implantation: A Review

Cited by 76 publications

References 209 publications

Waste-derived biomaterials as building blocks in the biomedical field

Waste-derived biomaterials as building blocks in the biomedical field

Multifunctionality of Nanosized Calcium Apatite Dual-Doped with Li+/Eu3+ Ions Related to Cell Culture Studies and Cytotoxicity Evaluation In Vitro

Проблема Використання Композитних Імплантів, Що Біодеградують, У Лікуванні Переломів Кісток (Огляд Літератури)

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