Current Clinical and Preclinical Photosensitizers for Use in Photodynamic Therapy

Detty, Michael R.; Gibson, Scott L.; Wagner, Stephen J.

doi:10.1021/jm040074b

Cited by 998 publications

(666 citation statements)

References 145 publications

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“…The estimation of the mean interaction energy of insoluble CuPc and H 2 Pc, and the soluble [CuPc(SO 3 ) 4 ] 4− in water, is coherent with the experimental behavior. Interestingly, the analysis of the surrounding solvent structure for the three compounds does not show as dramatic changes as may be expected from their different solubility character.…”

Section: Discussionsupporting

confidence: 77%

“…The labels employed are shown in Fig. 1(a), and Table 2S in the supplementary material 30 lists all the fitted coefficients and charges employed in expression (4). The fit quality is shown in Fig.…”

Section: Fig 2 Total and Two-body Interaction Energy Obtained Throumentioning

confidence: 99%

“…It involves the use of a photosensitizer (PS) in combination with visible light to produce reactive oxygen species which selectively destroy malignant cells. [1][2][3][4] A large number of metal-containing macrocycles have been synthesized and investigated for application in PDT, since the first approval of hematoporphyrin derivatives as a PS for PDT clinical applications. [5][6][7][8][9] Among many important technological applications, [10][11][12][13] phthalocyanines (Pcs) have been recently identified as promising PSs for PDT because their typical absorption at ∼ 680 nm is more intense than that corresponding to the porphyrin family.…”

Section: Introductionmentioning

confidence: 99%

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Modeling the interactions of phthalocyanines in water: From the Cu(II)-tetrasulphonate to the metal-free phthalocyanine

Martín

Martı́nez

Marcos

2011

The Journal of Chemical Physics

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A quantum and statistical study on the effects of the ions Cu 2+ and SO 3 − in the solvent structure around the metal-free phthalocyanine (H 2 Pc) is presented. We developed an ab initio interaction potential for the system CuPc- 4− in water and the understanding of the keys for the different behaviors of the three phthalocyanine (Pc) derivatives in water. The inclusion of the Cu 2+ cation in the Pc structure reinforces the appearance of two axial water molecules and second-shell water molecules in the solvent structure, whereas the presence of SO 3 − anions implies a well defined hydration shell of about eight water molecules around them making the macrocycle soluble in water. DebyeWaller factors for axial water molecules have been obtained in order to examine the potential sensitivity of the extended x-ray absorption fine structure technique to detect the axial water molecules.

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Section: Discussionsupporting

confidence: 77%

Section: Fig 2 Total and Two-body Interaction Energy Obtained Throumentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Modeling the interactions of phthalocyanines in water: From the Cu(II)-tetrasulphonate to the metal-free phthalocyanine

Martín

Martı́nez

Marcos

2011

The Journal of Chemical Physics

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“…[10][11][12] Некоторые из них успешно прошли доклинические и клинические испытания и применяются на практике. [13] Также известна фотобиологическая активность метал-лопорфиринов как инактиваторов бактерий [14] и вирусов. [15] Однако следует отметить, что большинство работ в данной области посвящено фотоактивности порфирино-вых молекул, и лишь в ряде из них рассматривается их темновая активность.…”

Section: Introductionunclassified

Formation and Bacteriostatic Properties of Ag(II) and Cu(II) Complexes of meso-Tetrakis(N-methyl-4-pyridyl)-porphyrin Tetratosylate

Вашурин¹,

Pukhovskaya²,

Garasko³

et al. 2014

MHC

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Изучена кинетика образования и устойчивость комплексов серебра и меди с тетратозилатом мезо-тетракис(N-метил-4-пиридил)порфирина в водных средах. Показана бактериостатическая активность без действия света для полученных металлопорфиринов.Ключевые слова: Порфирин, комплексообразование, водный раствор, бактериостатическая активность.

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“…The photo-activated oxidative cleavage of DNA has recently received considerable attention due to its utility in highly targeted photochemotherapeutic applications. For example porphyrin and phthalocyanin-based compounds have found clinical applications in photodynamic therapy (PDT) of cancer [11,12]. Among the non-porphyrinic species, the DNA photo-cleavage activity of 4d and 5d metal complexes has been studied in detail [13,14].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological activities of homo-binuclear Cu(II) and Zn(II) complexes derived from 2-hydroxy-5-methyl-1,3-benzenedicarboxaldehyde derivatives

Raman¹,

Arumugam²,

Jeyamurugan³

2010

Open Chemistry

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The data suggest that BHEM/BDEM/BTEM ligands afford square-pyramidal/distorted square-pyramidal geometry on metalation with Zn(II)/Cu(II). The binding behaviour of these complexes with DNA has been investigated using electronic absorption spectroscopy as well as viscosity and voltammetric measurements; the results show that they interact with DNA through intercalating way. From the DNA cleavage study of these complexes, investigated by gel electrophoresis, we found that they efficiently cleave supercoiled pUC19 DNA in the presence of a reducing agent (3-mercaptopropionic acid) and on irradiation with UV light of 360 nm wavelength. The mechanism reveals that singlet oxygen ( 1 O 2 ) plays a significant role in the photo cleavage. The superoxide dismutase (SOD) mimetic activity of the synthesized complexes demonstrates that most of the complexes have promising SOD-mimetic activity. The antimicrobial study indicates that the complexes inhibit the growth of bacteria and fungi more than the free ligands. Warsaw and Springer-Verlag Berlin Heidelberg. © Versita

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Current Clinical and Preclinical Photosensitizers for Use in Photodynamic Therapy

Cited by 998 publications

References 145 publications

Modeling the interactions of phthalocyanines in water: From the Cu(II)-tetrasulphonate to the metal-free phthalocyanine

Modeling the interactions of phthalocyanines in water: From the Cu(II)-tetrasulphonate to the metal-free phthalocyanine

Formation and Bacteriostatic Properties of Ag(II) and Cu(II) Complexes of meso-Tetrakis(N-methyl-4-pyridyl)-porphyrin Tetratosylate

Synthesis, characterization and biological activities of homo-binuclear Cu(II) and Zn(II) complexes derived from 2-hydroxy-5-methyl-1,3-benzenedicarboxaldehyde derivatives

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