Current evidence of temozolomide and bevacizumab in treatment of gliomas

Abstract

Our collected data support the addition of radiotherapy, BEV, and other targeted agents to TMZ treatment, indicating prolonged survival duration in newly diagnosed patients. However, the optimal regimen for treating high-grade glioma cannot be concluded without more clinical trials.

Clinical Applications of Iron Oxide Nanoparticles for Magnetic Resonance Imaging of Brain Tumors

“…Among the antiangiogenic drugs, bevacizumab (Avastin™; Genentech, CA, USA) is a monoclonal antibody that targets vascular endothelial growth factor [110]. Preclinical studies with ferumoxytol have shown reduction in rCBV values [101,102] and decreased permeability [102] in tumors following bevacizumab treatment.…”

18F-Fluorodeoxyglucose PET/Computed Tomography for Primary Brain Tumors

“…The tumors invariably recur, 90% of them at the original site, and therapeutic strategies in recurrent tumors are controversial. [13][14][15] Other types of brain tumors include extra-axial meningiomas (w30%), and a rare but distinctive kind is primary CNS lymphomas (PCNSL). 8,16 However, the bulk of literature on FDG-PET in primary brain tumors is on gliomas, which also is the focus of this article.…”

Prospect of natural products in glioma: A novel avenue in glioma management

“…Current standard glioma therapy involves surgical removal of tumor tissue followed by radiotherapy or chemotherapy (Pérez López & Otero Hernández, ). Tumor tissue removal by surgery is the best option in glioma therapy, but its feasibility depends on the tumor position in the brain (Nanegrungsunk, Onchan, Chattipakorn, & Chattipakorn, ). Although complete removal or debulking of the tumor tissue results in better prognosis by reducing the tumor volume and histological diagnosis (Taal, Bromberg, & van den Bent, ), it also includes the chances of recurrent tumor development at the original site or the distant site.…”

“…Although complete removal or debulking of the tumor tissue results in better prognosis by reducing the tumor volume and histological diagnosis (Taal, Bromberg, & van den Bent, ), it also includes the chances of recurrent tumor development at the original site or the distant site. Therefore, the continuation of adjuvant radiation or chemotherapy is vital to prevent tumor growth (Nanegrungsunk et al, ). Radiation includes many complications such as necrosis of brain tissues, cognitive impairment, and secondary tumor.…”

“…Radiation includes many complications such as necrosis of brain tissues, cognitive impairment, and secondary tumor. These adverse effects depend on the age and health condition of the patient, dose of radiation (Nanegrungsunk et al, ). Radiation is more effective in high‐grade gliomas, but a higher dose of radiation may have high risk–benefit ratio (Taal et al, ).…”