Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses

Xian, Dehai; Guo, Menglu; Xu, Jixiang; Yang, Yang; Zhao, Yangmeng; Zhong, Jianqiao

doi:10.1080/13510002.2021.1962094

Cited by 27 publications

(20 citation statements)

References 150 publications

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“…It has also been revealed that flavonoids exert an antiskin photoaging effect [ 10 ]. Xian et al [ 11 ] showed that flavonoids could reduce skin photodamage via various mechanisms such as inhibiting inflammation, scavenging free radicals, combatting oxidation, preventing DNA damage, and maintaining the normal synthesis and degradation of ECM in the skin. Flavonoids added in cosmetics can absorb UVA and UVB with wavelengths of 200–400 nm and have antiphotoaging effects by regulating sunburn signaling pathways [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects and Molecular Mechanism of Total Flavonoids from Lycium Barbarum Leaves on Photoaged Human Dermal Fibroblasts

Song

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the effects and corresponding mechanisms of total flavonoids (TFL) from Lycium barbarum leaves on photoaged human dermal fibroblasts (HDFs). Methods. Crude TFL was extracted with 70% ethanol, and a Rutin standard curve was drawn using the sodium nitrite-aluminum nitrate-sodium hydroxide colorimetry method to calculate its yield and mass concentration. After that, the photoaging HDFs model was established by UVA combined with 8-MOP. CCK-8 was performed to assess the influence of TFL on the proliferation of HDFs and photoaging HDFs. β-galactosidase (SA-β-gal) staining and activity assays were performed to evaluate the activity of SA-β-gal and the rate of SA-β-gal-positive cells in HDFs cells. The level of skin ECM proteins and oxidative stress-related substances in HDFs cells of each group was determined by ELISA and biochemical detection, respectively. Apoptosis of HDFs in each group was assessed by flow cytometry. The expressions of MAPK signaling pathway-related proteins in HDFs were detected by western blot. Results. The yield rate of TFL extracted by 70% ethanol was 41.9%, and its purity rate was 34.6%. TFL at 25, 50, and 100 μg/mL was able to greatly promote the proliferation of HDFs. A photoaged HDFs model was successfully constructed by combining UVA irradiation at 9 J/cm2 and 8-MOP at 50 mg/L. TFL treatment could significantly inhibit apoptosis, SA-β-gal-positive cell staining rate, SA-β-gal activity, lactate dehydrogenase (LDH) leakage, and malondialdehyde (MDA) content in photoaged HDFs. Further, TFL increased the proliferative activity, superoxide dismutase (SOD) activity, catalase (CAT) activity, type I collagen (Col I), hydroxyproline (HYP), and hyaluronic acid (HA) level of photoaged HDFs in a dose-dependent manner. Additional experiments suggested that TFL played a protective role by downregulating MAPK signaling pathway activity in photoaged HDFs cells. Conclusion. TFL could inhibit oxidative stress and apoptosis, promote cell proliferation and the level of ECM-related component proteins, and participate in antiphotoaging in a concentration-dependent manner. The protective role of TFL in photoaged HDFs might be related to its inhibition of MAPK signaling pathways.

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Section: Introductionmentioning

confidence: 99%

Protective Effects and Molecular Mechanism of Total Flavonoids from Lycium Barbarum Leaves on Photoaged Human Dermal Fibroblasts

Song

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…There is evidence for the preventive potential of luteolin in skin cancers associated with, inter alia skin photodamage as well as Nrf2 activity, closely related to oxidative stress. Luteolin suppresses the expression of COX‐2, AP‐1, and NF‐κB, regulates antioxidant enzymes, and prevents ROS accumulation and activation of MAKP and NF‐κB signaling pathways 207 . The antioxidant activity of luteolin is a partial contribution to its anti‐inflammatory effect, which is also related to the prevention of the carcinogenesis process due to the convergence of chronic inflammation and cancer 45,56 .…”

Section: Bioactivity Of Luteolin and Its Derivatives On Skin Cancermentioning

confidence: 99%

“…Luteolin suppresses the expression of COX‐2, AP‐1, and NF‐κB, regulates antioxidant enzymes, and prevents ROS accumulation and activation of MAKP and NF‐κB signaling pathways. 207 The antioxidant activity of luteolin is a partial contribution to its anti‐inflammatory effect, which is also related to the prevention of the carcinogenesis process due to the convergence of chronic inflammation and cancer. 45 , 56 This luteolin effect is mediated by cells such as neutrophils and lymphocytes; TNF‐α and IL‐6 release‐related inhibition; and signaling pathways involving these factors as previously described.…”

Section: Bioactivity Of Luteolin and Its Derivatives On Skin Cancermentioning

confidence: 99%

Skin cancer, including related pathways and therapy and the role of luteolin derivatives as potential therapeutics

Juszczak

Wölfle

Končić

2022

Medicinal Research Reviews

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Cutaneous malignant melanoma is the fastest growing and the most aggressive form of skin cancer that is diagnosed. However, its incidence is relatively scarce compared to the highest mortality rate of all skin cancers. The much more common skin cancers include nonmelanoma malignant skin cancers. Moreover, over the past several decades, the frequency of all skin cancers has increased much more dynamically than that of almost any other type of cancer. Among the available therapeutic options for skin cancers, chemotherapy used immediately after the surgical intervention has been an essential element. Unfortunately, the main problem with conventional chemopreventive regimens involves the lack of response to treatment and the associated side effects. Hence, there is a need for much more effective anticancer drugs. Correspondingly, the targeted alternatives have involved phytochemicals, which are safer chemotherapeutic agents and exhibit competitive anticancer activity with high therapeutic efficacy. Among polyphenolic compounds, some flavonoids and their derivatives, which are mostly found in medicinal plants, have been demonstrated to influence the modulation of signaling pathways at each stage of the carcinogenesis process, which is also important in the context of skin cancers. Hence, this review focuses on an exhaustive overview of the therapeutic effects of luteolin and its derivatives in the treatment and prevention of skin cancers. The bioavailability and structure–activity relationships of luteolin derivatives are also discussed. This review is the first such complete account of all of the scientific reports concerning this particular group of natural compounds that target a specific area of neoplastic diseases.

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“…It is used in the treatment and care of oily and polluted skin. Common nettle rich in quercetin, rutin and kaempferol is used as an external compress in case of seborrhea and inflammation [1,15,16]. By combining the above natural therapies, very good therapeutic effect can be achieved with less strain on the body.…”

Section: Psoriasismentioning

confidence: 99%

The role of flavonoids in prevention and treatment of selected skin diseases

Gębka¹,

Adamczyk²,

Gębka-Kępińska³

et al. 2022

J Pre Clin Clin Res.

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Introduction andOjective. The skin is the most important external organ, protecting against pathogens, physical and chemical injuries, as well as ultraviolat (UV) radiation. Continuous exposure to UV radiation, allergens, and pollutants, as well as consumption of highly processed foods, all promote the development and exacerbation of skin diseases, which appear highly differentiated. Skin diseases have a significant impact on the patient's quality of life and psychological well-being, which is why finding effective therapeutic compounds appears to be so important, especially since multiple conditions still remain untreated. The benefits of flavonoids in the management of psoriasis, acne, atopic dermatitis, urticaria, ringworm, and other skin diseases, are discussed in this review. Review methods. A search was conducted using PubMed and Google Scholar databases for articles, to assess the effect of flavonoids in the prevention and treatment of skin diseases. Articles in both Polish and English were searched for. To eliminate duplicate works, the bibliography was reviewed. Brief description of the state of knowledge. Flavonoids' antioxidant and photoprotective properties are the primary factors influencing their preventive use in the development of skin diseases. The risk of tumour formation is significantly reduced as a result of these two applications. They hasten the healing of long-lasting wounds and ulcers due to their circulation-stimulating properties. Plants high in flavonoids are used in dressings and poultices. Their extracts are used in creams and solutions to treat and prevent a variety of skin diseases. Summary. The antioxidant and anti-inflammatory effects of flavonoids makes them an important reference in the treatment of skin diseases. The advancement of natural medicinal substances is a critical aspect of modern medicine.

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Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses

Cited by 27 publications

References 150 publications

Protective Effects and Molecular Mechanism of Total Flavonoids from Lycium Barbarum Leaves on Photoaged Human Dermal Fibroblasts

Protective Effects and Molecular Mechanism of Total Flavonoids from Lycium Barbarum Leaves on Photoaged Human Dermal Fibroblasts

Skin cancer, including related pathways and therapy and the role of luteolin derivatives as potential therapeutics

The role of flavonoids in prevention and treatment of selected skin diseases

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