Current Knowledge on Nanodelivery Systems and Their Beneficial Applications in Enhancing the Efficacy of Herbal Drugs

Abstract

Herbal remedies have been extensively used since times immemorial throughout the world. These have wide acceptability due to their time-tested therapeutic values and minimal side effects in contrast to modern allopathic medicines. Commonly, the herbal medicines are available in the form of crude extracts prepared in different solvent systems which might not only need large dose administration but also could be less effective in the form of conventional formulations. Moreover, available phytoformulations do not have the ability for specific tissue target delivery in case of different chronic diseases. Oral administration of these herbal formulations is subjected to adverse pH, enzymatic degradation and ultimately poor gut absorption and bioavailability. With the advancements in biotechnology, genomics, and combinatorial chemistry, new, more potent and specific drug delivery systems have been envisaged during the last few decades. Constraints associated with conventional phytopharmaceuticals have been improved by designing and using -Nano Delivery Systems‖ (NDS). The foremost aim of NDS is to provide sustained drug release, site-specific action, and improved patient's compliance. Nano herbal medicines can be used to target them to the specific site in the body which improves their selectivity, solubility, delivery, safety, effectiveness and thus reduces the need for

Microfluidization trends in the development of nanodelivery systems and applications in chronic disease treatments

“…SLNs are among the lipid nanocarriers developed for transporting the hydrophobic bioactive compounds with higher loading capacity along with the enhanced stability of the loaded bioactive compounds. [54][55][56][57][58][59][60] SLNs showed higher loading efficacy and bioavailability of various plant bioactive compounds like curcumin, resveratrol, quercetin, and catechin. These plant-derived bioactive compound-loaded SLNs showed higher potential in the prevention and cure of various chronic diseases.…”

Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential

“…The main advantages of niosomes are flexibility, cost-effectiveness, higher drug solubility and controlled release of the encapsulated bioactive, making them an effective peptide carrier and hemoglobin carrier, targeting vehicle for neoplasia, providing transdermal drug delivery of entrapped molecules. Niosomes, on the other hand, demonstrated extended drug circulation, skin retention, and penetration, as well as sustained drug release at the target location [ 134 ]. These are more stable nanocarriers than liposomes, with no notable toxicity, especially for topical usage in the treatment of skin problems such as skin cancer [ 135 ].…”

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

“…97 In tropical application, niosomes were also showed prolonged circulation, sustained release and retention in the skin and facilitated the permeation of the drug into the skin. 98 Niosomes were reported to be more stable without significant toxicity than liposomes especially when used topically for treatment of skin diseases. In this regard, niosome loaded resveratrol for topical treatment of skin cancers is one of the potential candidate.…”