Current nutritional considerations for prevention of cervical cancer

Cox, Benjamin A.; Crow, William Thomas; Johnson, Lyn

doi:10.1016/j.osfp.2011.09.003

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…Although other studies have not found associations between dietary intake (e.g., fruit, milk, or specific nutrients such as vitamin D or folic acid, etc.) [21,22], similar to the findings in this study, meta-analysis have indicated that women with cervical dysplasia usually have significantly lower intakes of dietary antioxidants-considered as preventive factors for the development of neoplasms-including vitamin C, vitamin A, and carotenes [23,24]. Zinc, for its side, serves as cofactor for antioxidant enzymes (i.e., superoxide dismutase); thus other authors have proposed that zinc deficiency may be a risk factor for cervical cancer [25].…”

Section: Discussionsupporting

confidence: 87%

Differences in Dietary Components and Oxidative Stress Markers between Cervical Cancer Patients and Matched Controls

Gutiérrez-Salmeán¹

2015

J Nutri Med Diet Care

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Background and objective: Cervical cancer is a leading cause of death among women in developing countries. Diet has been suggested to play an important role in the pathophysiology of malignant tumors as an imbalance between dietary antioxidant intake and free radical production-from the inflammatory stateresults in oxidative stress, which may contibute to both initiation and progression of carcinogenesis. The aims of the present study were to assess the difference regarding dietary intake and oxidative stress plasmatic markers differences between cervical cancer patients and matched controls. Methods:A case-control study -nested within a larger clinical trial-including 100 patients diagnosed with locally advanced cervical cancer and 80 women without the malignant disease was conducted. A food frequency questionnaire was used for assessing diet. Plasmatic oxidative stress markers -malondialdehyde and free carbonyls-were also determined. Results:Patients with cervical cancer presented a significantly higher body mass index and higher consumption of dietary protein and fat, niacin, cholesterol, sodium, cyanocobalamin, vitamin E, and zinc. A significantly lower intake of vitamin C was found in the case group. MDA levels were found to be statistically higher in cervical cancer patients while free carbonyls did not show significant differences. Conclusions:A high-fat/high-protein diet, together with lower consuption of ascorbic acid may contribute to an increase risk of developing cervical cancer. However, further prospective and longitudinal research should be promoted in order to elucidate such associations.

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Section: Discussionsupporting

confidence: 87%

Differences in Dietary Components and Oxidative Stress Markers between Cervical Cancer Patients and Matched Controls

Gutiérrez-Salmeán¹

2015

J Nutri Med Diet Care

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“…In addition to HPV infection, different risk factors have been associated with the development of cervical cancer, such as early age at first sexual intercourse, number of sexual partners, high parity, education level, smoking habit, use of hormonal contraceptives and certain dietary deficiencies [16][17][18][19][20][21]. In our study, as depicted in Table 1, the number of pregnancies in women with CC was significantly higher than that in patients with CIN 1; different reports have shown that parity ≥3 is correlated with the risk of CC development.…”

Section: Discussionmentioning

confidence: 99%

High frequency of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico

et al. 2020

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Background Human papillomavirus infection is an important factor associated with cervical cancer (CC) development. The prevalence and genotype distribution vary greatly worldwide. Examining local epidemiological data constitutes an important step towards the development of vaccines to prevent CC. In this work, we studied the prevalence of HPV genotypes in women from Western Mexico with the COBAS 4800 and/or Linear Array Genotyping Test (LA). Methods The samples analysed in this study represent a population from Western Mexico, which includes six different states. Our approach was first to test for HPV in cervical samples from women who attended their health clinic for routine gynaecological studies (open-population, n = 3000) by utilizing COBAS 4800. Afterwards, 300 of the HPV-positive samples were randomly selected to be genotyped with LA; finally, we genotyped samples from women with cervical intraepithelial neoplasia grade 1 (CIN 1, n = 71) and CC (n = 96) with LA. Sociodemographic data of the diverse groups were also compared. Results The overall HPV prevalence among the open-population of women as determined by COBAS 4800 was 12.1% (n = 364/3000). Among the HPV-positive samples, single infections (SI) with HPV16 were detected in 12.4% (n = 45/364), SI with HPV18 were detected in 1.4%, and infection with at least one of the genotypes included in the high-risk HPV pool was detected in 74.5% of the cases. LA analysis of the samples showed that in addition to HPV genotypes 16 and 18, there was a high prevalence of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico. With respect to the sociodemographic data, we found statistically significant differences in the number of pregnancies, the use of hormonal contraceptives and tobacco intake. Conclusions Our data indicate that there is a high prevalence of HPV genotypes which are not covered by the vaccines currently available in Mexico; therefore, it is necessary to include HPVs 59, 66, 51, 39 and 56 in the design of future vaccines to reduce the risk of CC development. It is also essential to emphasize that the use of hormonal contraceptives and tobacco smoking are risk factors for CC development in addition to the presence of HPV.

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“…Cervical cancer is one of the disastrous menaces to women’s lives. Most of them have not been diagnosed [ 6 ]. In recent years cervical cancer has been a concern to primary physicians [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Association of dietary intake and cervical cancer: a prevention strategy

Nazari,

Hasanzadeh,

Rezvani

et al. 2023

Infect Agents Cancer

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Introduction Cervical cancer is one of lethal cancers in women. As a global concern, identifying important factors of cancer is a useful strategy for prevention. Due to the role of diet/nutrition factors for cancer, the purpose of our study was to determine the impact of 150 nutrition/vitamin factors and 50 non-nutritional factor in cervical cancer and phase. Methods Population samples of 2088 healthy subjects and patients with cervical cancer were investigated. 200 factors such as vitamin E, B1, B6, fruits, HPV, and age were gathered. Deep learning, Decision tree, and correlation matrix were used for modeling and identifying important factors. SPSS 26, R4.0.3, and Rapid miner were utilized for implementation. Results Our findings indicated that zinc, Iron, Niacin, Potassium, Phosphorous, and Cooper have a beneficial impact in reducing the risk of cervical cancer and progression of phase in Iranian women, as well as Salt, snacks and milk Were identified as high-risk food factors (P value < 0.05 and coefficient correlation > 0.6). Also, alcohol, and sex patient with two groups, HPV positive have an impact on cervical cancer incidence. Phosphorus and selenium in the Micronutrients category (R2 = 0.85, AUC = 0.993) and polyunsaturated fatty acid and salt in the Macronutrients category and other categories of nutrients were identified as the most effective factors in cervical cancer using deep learning (R2 = 0.93, AUC = 0.999). Conclusions A diet and rich nutrition can be helpful for the prevention of cervix cancer and may reduce the risk of disease. Additional research is necessary for different countries.

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Current nutritional considerations for prevention of cervical cancer

Cited by 6 publications

References 24 publications

Differences in Dietary Components and Oxidative Stress Markers between Cervical Cancer Patients and Matched Controls

Differences in Dietary Components and Oxidative Stress Markers between Cervical Cancer Patients and Matched Controls

High frequency of HPV genotypes 59, 66, 52, 51, 39 and 56 in women from Western Mexico

Association of dietary intake and cervical cancer: a prevention strategy

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