Current Progress in the Endogenous Repair of Intervertebral Disk Degeneration Based on Progenitor Cells

Zhang, Yanbin; Hu, Yiqiang; Wang, Wentian; Guo, Zhixin; Yang, Fan; Cai, Xianyi; Xiong, Liming

doi:10.3389/fbioe.2020.629088

Cited by 12 publications

(19 citation statements)

References 125 publications

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“…Another possibility is that after multiple rounds of differentiation and proliferation, the self-renewal ability of IVD stem cells becomes exhausted in response to degeneration-related or age-related damage. The possible reason includes nutrition deprivation, hypoxia, less reactive oxygen species, inflammatory factors, increased extracellular matrix (ECM) stiffness, and cyclic tension ( Li et al, 2014 ; Zhang et al, 2020b ; Zehra et al, 2022 ).…”

Section: The Degenerated Ivd Microenvironmentmentioning

confidence: 99%

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The role of microenvironment in stem cell-based regeneration of intervertebral disc

Chu

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Regenerative medicine for intervertebral disc (IVD) disease, by utilizing chondrocytes, IVD cells, and stem cells, has progressed to clinical trials in the treatment of back pain, and has been studied in various animal models of disc degeneration in the past decade. Stem cells exist in their natural microenvironment, which provides vital dynamic physical and chemical signals for their survival, proliferation and function. Long-term survival, function and fate of mesenchymal stem cells (MSCs) depend on the microenvironment in which they are transplanted. However, the transplanted MSCs and the endogenous disc cells were influenced by the complicated microenvironment in the degenerating disc with the changes of biochemical and biophysical components. It is important to understand how the MSCs and endogenous disc cells survive and thrive in the harsh microenvironment of the degenerative disc. Furthermore, materials containing stem cells and their natural microenvironment have good clinical effects. However, the implantation of tissue engineering IVD (TE-IVD) cannot provide a complete and dynamic microenvironment for MSCs. IVD graft substitutes may need further improvement to provide the best engineered MSC microenvironment. Additionally, the IVD progenitor cells inside the stem cell niches have been regarded as popular graft cells for IVD regeneration. However, it is still unclear whether actual IVD progenitor cells exist in degenerative spinal conditions. Therefore, the purpose of this review is fourfold: to discuss the presence of endogenous stem cells; to review and summarize the effects of the microenvironment in biological characteristics of MSC, especially those from IVD; to explore the feasibility and prospects of IVD graft substitutes and to elaborate state of the art in the use of MSC transplantation for IVD degeneration in vivo as well as their clinical application.

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Section: The Degenerated Ivd Microenvironmentmentioning

confidence: 99%

“…The possible reason includes nutrition deprivation, hypoxia, less reactive oxygen species, inflammatory factors, increased extracellular matrix (ECM) stiffness, and cyclic tension Zhang et al, 2020b;Zehra et al, 2022).…”

Section: The Degenerated Ivd Microenvironmentmentioning

confidence: 99%

The role of microenvironment in stem cell-based regeneration of intervertebral disc

Chu

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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“…A primary concern with stem cell-based therapies is with the potential loss of cells and diminished viability upon administration [ 28 ]. Due to the biological and ethical concerns that arise with the use of stem cells, it would be difficult to justify repeated implantation, which could potentially be necessary if challenges associated with administration cannot be adequately addressed [ 23 ]. Furthermore, the transplantation of exogenous cells is expensive.…”

Section: Cell-based Therapies For Ivddmentioning

confidence: 99%

“…There has been progress with these studies, but there are concerns about a low survival rate of transplanted cells, which would make it difficult for researchers to control for cell viability and differentiation, and the risk of mutation [ 21 , 22 ]. With embryonic stem cells, there is also a potential lack of institutional readiness and societal acceptance [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration

Krut

Pelled

Gazit

et al. 2021

Cells

103

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Intervertebral disc degeneration (IVDD) occurs as a result of an imbalance of the anabolic and catabolic processes in the intervertebral disc, leading to an alteration in the composition of the extracellular matrix (ECM), loss of nucleus pulposus (NP) cells, excessive oxidative stress and inflammation. Degeneration of the IVD occurs naturally with age, but mechanical trauma, lifestyle factors and certain genetic abnormalities can increase the likelihood of symptomatic disease progression. IVDD, often referred to as degenerative disc disease (DDD), poses an increasingly substantial financial burden due to the aging population and increasing incidence of obesity in the United States. Current treatments for IVDD include pharmacological and surgical interventions, but these lack the ability to stop the progression of disease and restore the functionality of the IVD. Biological therapies have been evaluated but show varying degrees of efficacy in reversing disc degeneration long-term. Stem cell-based therapies have shown promising results in the regeneration of the IVD, but face both biological and ethical limitations. Exosomes play an important role in intercellular communication, and stem cell-derived exosomes have been shown to maintain the therapeutic benefit of their origin cells without the associated risks. This review highlights the current state of research on the use of stem-cell derived exosomes in the treatment of IVDD.

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“…In addition to pain, LBP restricts physical activity and can lead to disabilities. Additionally, it causes a major socioeconomic burden [ 1 – 4 ]. Clinically, LBP always positively correlates with the degeneration of the intervertebral disc (IVD) [ 2 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Intervertebral Disc Stem/Progenitor Cells: A Promising “Seed” for Intervertebral Disc Regeneration

Wang

et al. 2021

Stem Cells International

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Intervertebral disc (IVD) degeneration is considered to be the primary reason for low back pain (LBP), which has become more prevalent from 21 century, causing an enormous economic burden for society. However, in spite of remarkable improvements in the basic research of IVD degeneration (IVDD), the effects of clinical treatments of IVDD are still leaving much to be desired. Accumulating evidence has proposed the existence of endogenous stem/progenitor cells in the IVD that possess the ability of proliferation and differentiation. However, few studies have reported the biological properties and potential application of IVD progenitor cells in detail. Even so, these stem/progenitor cells have been consumed as a promising cell source for the regeneration of damaged IVD. In this review, we will first introduce IVD, describe its physiology and stem/progenitor cell niche, and characterize IVDSPCs between homeostasis and IVD degeneration. We will then summarize recent studies on endogenous IVDSPC-based IVD regeneration and exogenous cell-based therapy for IVDD. Finally, we will discuss the potential applications and future developments of IVDSPC-based repair of IVD degeneration.

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Current Progress in the Endogenous Repair of Intervertebral Disk Degeneration Based on Progenitor Cells

Cited by 12 publications

References 125 publications

The role of microenvironment in stem cell-based regeneration of intervertebral disc

The role of microenvironment in stem cell-based regeneration of intervertebral disc

Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration

Intervertebral Disc Stem/Progenitor Cells: A Promising “Seed” for Intervertebral Disc Regeneration

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