Current state on the development of nanoparticles for use against bacterial gastrointestinal pathogens. Focus on chitosan nanoparticles loaded with phenolic compounds

Madureira, Ana Raquel; Pereira, Adriana Bernardes; Pintado, Manuela

doi:10.1016/j.carbpol.2015.05.030

Cited by 53 publications

(30 citation statements)

References 105 publications

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“…CNP loaded with different extracts containing polyphenols were reported too as follows: tea polyphenol extract [ 19 ], Elsholtzia splendens extract [ 20 ], olive tree leaves extract, and Yerba mate ( Ilex paraguariensis ) extract [ 21 ]. All nanoparticles showed important antioxidant activity.…”

Section: Phenolic Compounds From Plant Sources Delivered As Nanopartimentioning

confidence: 98%

“…All nanoparticles showed important antioxidant activity. CNP loaded with catechin, quercetin, and epigallocatechin showed strong antioxidant activity too [ 21 ] while CNP loaded with (−)-epigallocatechin-3-gallate showed nanochemoprevention properties [ 22 ].…”

Section: Phenolic Compounds From Plant Sources Delivered As Nanopartimentioning

confidence: 99%

“…CNP effective against microorganisms important for skin care and in skin healing were prepared encapsulating different active agents: thymol (active against S. aureus, P. aeruginosa, Candida albicans) [ 21 ], carvacrol (from oregano, thyme, and marjoram essential oils) [ 23 ]. Other CNP were loaded with essential oils from Lavandula spp., Thymus vulgaris, Rosmarinus offi cinalis, Hissopus offi cinalis, and Satureja montana [ 24 ].…”

Section: Essential Oils Delivered In Nanostructuresmentioning

confidence: 99%

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Bionanomaterials from Plant Sources

Leonida

Kumar

2016

SpringerBriefs in Bioengineering

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At the present an unprecedented interest in herbal healing is appearing everywhere. The Western world started to compare allopathic remedies (with many side effects) to the traditional ones and to acknowledge the latter as safer alternatives. In spite of their advantages, applications are slow to materialize, with poor solubility and low bioavailability being the main reasons. Natural products such as curcumin, hop extracts, essential oils are example of species with demonstrated biological activity but few applications due to unsatisfactory bioavailability correlated with low water solubility. Natural products with strong antioxidant effect, like polyphenols in teas, for example, are not widely used because of their sensitivity to oxidation (during processing and storage).Nanotechnology offers a huge promise for these compounds. The disadvantages mentioned disappear upon encapsulating them in nanosized carriers with appropriate chemistry. An added bonus thereof is the possibility of controlled delivery. Phenolic Compounds from Plant Sources Delivered as NanoparticlesPolyphenols are chemical structures in which there is at least one aromatic ring with a reactive hydroxyl group and they are classifi ed according to the number and the structural elements linking these rings. They can be found in several plants (mostly in leaves and fruits) and came to public attention when their capacity to fi ght reactive oxygen species (ROS) was discovered. Phenolics (including fl avonoids, anthocyanins, lignins) are secondary metabolites in plants and are important for disease resistance, tolerance to abiotic stress, and for fi ghting bacteria. Tolerance of bacteria for polyphenols depends on the type of bacterium and the structure of the polyphenol.

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Section: Phenolic Compounds From Plant Sources Delivered As Nanopartimentioning

confidence: 98%

Section: Phenolic Compounds From Plant Sources Delivered As Nanopartimentioning

confidence: 99%

Section: Essential Oils Delivered In Nanostructuresmentioning

confidence: 99%

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Bionanomaterials from Plant Sources

Leonida

Kumar

2016

SpringerBriefs in Bioengineering

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“…Recientemente, la investigación y el desarrollo en el envasado de alimentos activa se han centrado en los materiales de envasado funcionales de base biológica que incorporan compuestos e ingredientes (Madureira, 2015). Se han realizado muchos estudios sobre la utilización de los polifenoles vegetales como alternativas a los agentes antimicrobianos y antioxidantes sintéticos (Evrendilek, 2015).…”

Section: Estudios Recientes De La Aplicación De Propóleo En Envasado unclassified

Propopoli's aplication on active packaging

Rebaza¹,

Amaya²,

Gutiérrez³

et al. 2016

Agroind.Sc

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RESUMENLas investigaciones relacionadas con el envasado activo están encaminados hacia la caracterización de nuevas películas basadas en hidrocoloides de fuentes no convencionales y la adición de agentes que proporcionen funcionalidad al envase. A los propóleos se les atribuyen diferentes propiedades biológicas, tales como: antitumorales, antiprotozoarias, antivirales, antioxidantes, antiinflamatorias, antibacteriales y antifúngicas; en particular, se ha encontrado que esta sustancia inhibe el desarrollo de patógenos de poscosecha como Botrytis cinerea y Penicillium expansum. El efecto de la incorporación de propóleo en propiedades funcionales de películas de quitosano, dentro de las propiedades estudiadas se determinó que la adición de propóleo redujo la permeabilidad de vapor de agua en las películas. Por otro lado, la incorporación de propóleo en películas a base de hidroxipropilmetilcelulosa, dieron lugar a una ligera disminución en la densidad y el pH. Respecto a las propiedades mecánicas, las películas de propóleo mostraron mayor alargamiento a la rotura (%) y los valores más bajos de resistencia a la tracción y módulos elásticos. El estudio permitió demostrar el efecto antibacteriano de ambos extractos de propóleo (los extractos etanólicos de propóleo fueron más efectivos que los extractos acuosos), además de que la actividad antibacteriana depende del lugar del que se extrae el propóleo y de la resistencia de estos microorganismos, siendo que las bacterias Gram-positivas son más susceptibles que las bacterias Gram-negativas. Las películas que contienen propóleos mostraron una notable actividad antifúngica contra los hongos ensayados, que fue más intensa frente a A. nigerthan contra Penicillium specie y componentes del propóleo tales como la rutina, quercetina y naringenina fueron los principales compuestos fenólicos del propóleo por lo que a la vez fueron los principales contribuyentes a la actividad antioxidante.Palabras clave: Envase activo, propóleo, propiedades mecánicas, antibacterial, antifúngico, antioxidante. ABSTRACTThe researches related to active packaging are directed towards the characterization of new films based on hydrocolloids from unconventional sources and the addition of agents to provide functionality to the package. A propolis are attributed different biological properties such as: anti-tumor, antiprotozoal, antiviral, antioxidant, antiinflammatory, antibacterial and antifungal; in particular, it has been found that this substance inhibits the development of postharvest pathogens such as Botrytis cinerea and Penicillium expansum. The effect of incorporating propolis into functional properties of chitosan films within the properties studied determined that the addition of propolis reduced the permeability of water vapor in the movies. Otherwise propolis addition in films to hydroxypropyl methylcellulose base, gave in a slight decrease in the density and pH. Regarding the mechanical properties, the films of propolis showed higher elongation at break (%) and the lowest values of tensil...

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“…This, together with its adhesivity, made it interesting for skin applications as well. High molecular weight chitosans have been found more active against gram positive bacteria while low molecular weight ones were more active against gram negative species [ 7 ]. Positively charged chitosan binds to the negatively charged bacterial membrane, triggering agglutination and/or an increase in its permeability, resulting in leakage of cellular components.…”

mentioning

confidence: 99%

Nanochitosan and the Skin

Leonida

Kumar

2016

SpringerBriefs in Bioengineering

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Chitosan is a non-toxic, biodegradable, polycationic polysaccharide, easily obtained from the naturally abundant chitin from the exoskeleton of crustaceans (Fig. 9.1 ) through deacetylation (partial, typically 66-95 %) and partial depolymerization (less extensive). It is a polymeric 2-amino-2-deoxy-β-D-glucan formed through 1→4 glycosidic linkages. The interest in chitosan as delivery vehicle for active species was generated by the knowledge that it is broken down by the enzyme lysozyme in the human body releasing harmless amino sugars [ 1 ], hence biocompatible. The rate and extent of its biodegradability depends on its degree of deacetylation (DD), slower for higher DD values [ 2 ].Great interest in this semisynthetic biopolymer obtained from renewable sources (chitin) stems from its remarkable properties : adhesivity, antimicrobial and antifungal effect, immunity enhancing effect, chelating effect, fi lm and gel forming abilities. As such it found applications in pharmaceuticals, as drug delivery vehicle or vaccine carrier, in biotechnology as gene delivery system, in textiles, spun into fi bers or as a coating, in dentistry, in removal of heavy metals from waste waters, as preservative in the food industry, and many others.Chitosan was found active against both gram positive and gram negative bacteria [ 3 -5 ], and fungi [ 6 ]. This, together with its adhesivity, made it interesting for skin applications as well. High molecular weight chitosans have been found more active against gram positive bacteria while low molecular weight ones were more active against gram negative species [ 7 ]. Positively charged chitosan binds to the negatively charged bacterial membrane, triggering agglutination and/or an increase in its permeability, resulting in leakage of cellular components. The fact that chitosan can chelate metals and thereby contributes to inhibiting some enzymatic activities is also part of its biological activity.Being nontoxic and biocompatible , chitosan has been approved by the FDA for use in wound dressings [ 8 ]. As a wound healing biodegradable material chitosan is

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Current state on the development of nanoparticles for use against bacterial gastrointestinal pathogens. Focus on chitosan nanoparticles loaded with phenolic compounds

Cited by 53 publications

References 105 publications

Bionanomaterials from Plant Sources

Bionanomaterials from Plant Sources

Propopoli's aplication on active packaging

Nanochitosan and the Skin

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