Current therapies for wound healing: electrical stimulation, biological therapeutics, and the potential for gene therapy

Braddock, Martin; Campbell, Callum J.; Zuder, D.

doi:10.1046/j.1365-4362.1999.00832.x

Cited by 66 publications

(39 citation statements)

References 90 publications

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“…Inflammation is the primary reaction at a wound site [1,2], followed by cellular proliferation, extra cellular matrix syntheses, remodelling and scar formation [2]. Cytokines, platelets, macrophages, neutrophils and monocytes all play an important role in the wound healing process [2].…”

Section: Introductionmentioning

confidence: 99%

Effect of a single acupuncture treatment on surgical wound healing in dogs: a randomized, single blinded, controlled pilot study

et al. 2010

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BackgroundThe aim of the study was to investigate the effect of acupuncture on wound healing after soft tissue or orthopaedic surgery in dogs.Methods29 dogs were submitted to soft tissue and/or orthopaedic surgeries. Five dogs had two surgical wounds each, so there were totally 34 wounds in the study. All owners received instructions for post operative care as well as antibiotic and pain treatment. The dogs were randomly assigned to treatment or control groups. Treated dogs received one dry needle acupuncture treatment right after surgery and the control group received no such treatment. A veterinary surgeon that was blinded to the treatment, evaluated the wounds at three and seven days after surgery in regard to oedema (scale 0-3), scabs (yes/no), exudate (yes/no), hematoma (yes/no), dermatitis (yes/no), and aspect of the wound (dry/humid).ResultsThere was no significant difference between the treatment and control groups in the variables evaluated three and seven days after surgery. However, oedema reduced significantly in the group treated with acupuncture at seven days compared to three days after surgery, possibly due the fact that there was more oedema in the treatment group at day three (although this difference was nor significant between groups).ConclusionsThe use of a single acupuncture treatment right after surgery in dogs did not appear to have any beneficial effects in surgical wound healing.

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Section: Introductionmentioning

confidence: 99%

Effect of a single acupuncture treatment on surgical wound healing in dogs: a randomized, single blinded, controlled pilot study

et al. 2010

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“…78,79 It is not of a surprise that the annual worldwide market for products that promote healing in such circumstances exceed $5 billion. 80 Therefore, potentially efficient and safe tissue engineering approaches involving the use of MSCs in "hard-to-heal" wounds could result in attractive and prosperous future applications.…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Do Mesenchymal Stem Cells Have a Role to Play in Cutaneous Wound Healing?

Pountos¹,

Panteli²,

Georgouli³

et al. 2014

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Cutaneous wounds represent a significant healthcare problem despite our increasing understanding of the molecular and cellular events governing this process. A major contributor to this problem is the lack of reliable therapies for the treatment of "hard-to-heal" wounds. Tissue engineering with the use of mesenchymal stem cells (MSCs) have emerged as a promising therapeutic tool with favorable early experimental and clinical results. This manuscript aims to provide an overview of the available approaches to up-regulate the cutaneous wound response with the use of MSCs.

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“…The administration of several recombinant growth factors has shown clinical improvement in wound-healing rates in preclinical animal models (62)(63)(64)(65). In incisional wound healing, PDGF induces fibroblast proliferation and differentiation, collagen deposition and angiogenesis (66,67).…”

Section: Growth Factors In Preclinical Studiesmentioning

confidence: 99%