Current trends in the design of scaffolds for computer-aided tissue engineering

Giannitelli, Sara Maria; Accoto, Dino; Trombetta, Marcella; Rainer, Alberto

doi:10.1016/j.actbio.2013.10.024

Cited by 399 publications

(274 citation statements)

References 151 publications

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“…There are several studies in the literature which are concentrated on the numerical analysis of bone scaffolds, especially using the finite element method. This method has been utilized effectively for the prediction of mechanical properties of additive manufactured scaffolds (Giannitelli et al, 2014). Boccaccio et al (Boccaccio et al, 2011) developed computational mechno-regulation models for determining porosity as well as structural response of scaffolds during the time.…”

Section: Figure 1 Schematic Diagram Of the Fdm Machinementioning

confidence: 99%

“…Therefore, researchers have gone toward preparation of suitable structural frameworks named bone scaffold to provide a support for cells (Jariwala et al, 2015;Poh, 2014). Such structures should have appropriate geometrical and mechanical properties in order to provide suitable bone treatment (Giannitelli et al, 2014;Sanz-Herrera et al, 2008;Yang et al, 2001). In this regard, Dias et al (Dias et al, 2014) proposed a topology optimization algorithm for designing scaffolds that satisfy both mass transport and mechanical load bearing capacity.…”

Section: Introductionmentioning

confidence: 99%

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Numerical investigation of the mechanical properties of the additive manufactured bone scaffolds fabricated by FDM: The effect of layer penetration and post-heating

Naghieh

Karamooz-Ravari

Badrossamay

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

127

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In recent years, thanks to additive manufacturing technology, researchers have gone towards the optimization of bone scaffolds for the bone reconstruction. Bone scaffolds should have appropriate biological as well as mechanical properties in order to play a decisive role in bone healing. Since the fabrication of scaffolds is time consuming and expensive, numerical methods are often utilized to simulate their mechanical properties in order to find a nearly optimum one. Finite element analysis is one of the most common numerical methods that is used in this regard. In this paper, a parametric finite element model is developed to assess the effects of layer adhesion on the mechanical properties of bone scaffolds. To be able to validate this model, some compression test specimens as well as bone scaffolds are fabricated with biocompatible and biodegradable poly lactic acid using fused deposition modeling. All these specimens are tested in compression and their elastic modulus is obtained. Using the material parameters of the compression test specimens, the finite element analysis of the bone scaffold is performed. The obtained elastic modulus is compared with experiment indicating a good agreement. Accordingly, the proposed finite element model is able to predict the mechanical behavior of fabricated bone scaffolds accurately. In addition, the effect of post-heating of bone scaffolds on their elastic modulus is investigated. The results demonstrate that the numerically predicted elastic modulus of scaffold is closer to experimental outcomes in comparison with as-build samples.

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Section: Figure 1 Schematic Diagram Of the Fdm Machinementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Numerical investigation of the mechanical properties of the additive manufactured bone scaffolds fabricated by FDM: The effect of layer penetration and post-heating

Naghieh

Karamooz-Ravari

Badrossamay

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

127

View full text Add to dashboard Cite

show abstract

“…29). Examples of unit cells are shown in [12][16] [128][140] [348]. The size, type, orientation, and boundary conditions of the periodic unit cell usually [12] (but not always [349]) affect the porosity, mechanical properties, and the deformation and failure mechanisms of the resulting materials.…”

Section: Lattices Trusses and Cellular Materials For Custom Materialsmentioning

confidence: 99%

Design for Additive Manufacturing: Trends, opportunities, considerations, and constraints

et al. 2016

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The past few decades have seen substantial growth in Additive Manufacturing (AM) technologies. However, this growth has mainly been process-driven. The evolution of engineering design to take advantage of the possibilities afforded by AM and to manage the constraints associated with the technology has lagged behind. This paper presents the major opportunities, constraints, and economic considerations for Design for Additive Manufacturing. It explores issues related to design and redesign for direct and indirect AM production. It also highlights key industrial applications, outlines future challenges, and identifies promising directions for research and the exploitation of AM's full potential in industry.Design, Manufacturing, Additive Manufacturing

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“…Based on our current experience, we believe that the use of a rigid mesh such as titanium is necessary for damping dural pulsations to offer optimal circumstances for bone formation when granular scaffold material is used. On the other hand, titanium and other materials may provide surfaces supporting the migration of osteoblasts 58, 59. In our series, the titanium‐containing constructs (Patients 1 and 5) had good intermediate follow‐up results and the observed osteolysis was due to non‐reconstruction related causes (Patient 1) and recurrent meningioma (Patient 5).…”

Section: Discussionmentioning

confidence: 63%

Cranioplasty with Adipose-Derived Stem Cells, Beta-Tricalcium Phosphate Granules and Supporting Mesh: Six-Year Clinical Follow-Up Results

Thesleff

Lehtimäki

Niskakangas

et al. 2017

Stem Cells Translational Medicine

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Several alternative techniques exist to reconstruct skull defects. The complication rate of the cranioplasty procedure is high and the search for optimal materials and techniques continues. To report long‐term results of patients who have received a cranioplasty using autologous adipose‐derived stem cells (ASCs) seeded on beta‐tricalcium phosphate (betaTCP) granules. Between 10/2008 and 3/2010, five cranioplasties were performed (four females, one male; average age 62.0 years) using ASCs, betaTCP granules and titanium or resorbable meshes. The average defect size was 8.1 × 6.7 cm2. Patients were followed both clinically and radiologically. The initial results were promising, with no serious complications. Nevertheless, in the long‐term follow‐up, three of the five patients were re‐operated due to graft related problems. Two patients showed marked resorption of the graft, which led to revision surgery. One patient developed a late infection (7.3 years post‐operative) that required revision surgery and removal of the graft. One patient had a successfully ossified graft, but was re‐operated due to recurrence of the meningioma 2.2 years post‐operatively. One patient had an uneventful clinical follow‐up, and the cosmetic result is satisfactory, even though skull x‐rays show hypodensity in the borders of the graft. Albeit no serious adverse events occurred, the 6‐year follow‐up results of the five cases are unsatisfactory. The clinical results are not superior to results achieved by conventional cranial repair methods. The use of stem cells in combination with betaTCP granules and supporting meshes in cranial defect reconstruction need to be studied further before continuing with clinical trials. Stem Cells Translational Medicine 2017;6:1576–1582

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Current trends in the design of scaffolds for computer-aided tissue engineering

Cited by 399 publications

References 151 publications

Numerical investigation of the mechanical properties of the additive manufactured bone scaffolds fabricated by FDM: The effect of layer penetration and post-heating

Numerical investigation of the mechanical properties of the additive manufactured bone scaffolds fabricated by FDM: The effect of layer penetration and post-heating

Design for Additive Manufacturing: Trends, opportunities, considerations, and constraints

Cranioplasty with Adipose-Derived Stem Cells, Beta-Tricalcium Phosphate Granules and Supporting Mesh: Six-Year Clinical Follow-Up Results

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