Cutaneous Cryptococcosis Mimicking Basal Cell Carcinoma in a Patient with Sézary Syndrome

Törőcsik, Dániel; Gergely, Lajos; Veres, Imre; Remenyik, Éva; Bégány, Ágnes

doi:10.2340/00015555-1326

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…Infections caused by non‐neoformans cryptococci are rare; to our knowledge, only three cases with cutaneous involvement were published so far. Similar to C. neoformans , C. albidus infection of the skin results in ulcerative lesions, most commonly on the face and neck . In all three published cases, the patients were immunocompromised; likewise, in our case the patient has been receiving long‐term oral corticosteroid treatment.…”

Section: Discussionmentioning

confidence: 60%

Cutaneous Cryptococcus albidus infection

et al. 2017

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Section: Discussionmentioning

confidence: 60%

Cutaneous Cryptococcus albidus infection

et al. 2017

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“…In the reviewed cases, 86 patients (15%) were reported to have solid tumours, although four patients also had a concurrent haematologic malignancy (chronic lymphocytic leukaemia & prostate cancer, adult T‐cell leukaemia/lymphoma & gastric cancer, myeloproliferative disorder & liver cancer, cutaneous T‐cell lymphoma & breast cancer). These four patients were counted as haematologic malignancy rather than solid tumour for analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The PubMed search resulted in 545 manuscripts, 137 of which contained unique and relevant patient data and fulfilled the inclusion and exclusion criteria . These publications included a total of 581 cases of cryptococcal disease in cancer patients.…”

Section: Methodsmentioning

confidence: 99%

Cryptococcus neoformans infection in malignancy

Schmalzle

Buchwald

Gilliam

et al. 2016

Mycoses

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Cryptococcosis is an opportunistic invasive fungal infection that is well described and easily recognised when it occurs as meningitis in HIV-infected persons. Malignancy and its treatment may also confer a higher risk of infection with Cryptococcus neoformans, but this association has not been as well described. A case of cryptococcosis in a cancer patient is presented, and all cases of coincident C. neoformans infection and malignancy in adults published in the literature in English between 1970 and 2014 are reviewed. Data from these cases were aggregated in order to describe the demographics, type of malignancy, site of infection, clinical manifestations, treatment and outcomes of cryptococcosis in patients with cancer. Haematologic malignancies accounted for 82% of cases, with lymphomas over-represented compared to US population data (66% vs. 53% respectively). Cryptococcosis was reported rarely in patients with solid tumours. Haematologic malignancy patients were more likely to have central nervous system (P < 0.001) or disseminated disease (P < 0.001), receive Amphotericin B as part of initial therapy (P = 0.023), and had higher reported mortality rates than those with solid tumours (P = 0.222). Providers should have heightened awareness of the possibility of cryptococcosis in patients with haematologic malignancy presenting with infection.

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“…1,4 Reported cryptococcal skin lesions include, but are not limited to, papules, nodules, acneiform lesions, granulomas, herpetiform vesicles, abscesses, and ulcers. 3,5 Cellulitis, whitlow, and ulceration are the most common clinical features in primary cutaneous cryptococcosis, whereas umbilicated papules resembling molluscum contagiosum are often seen as the skin manifestations during disseminated cryptococcosis. 4 The treatment of cryptococcosis is based on whether the infection is systemic or localized.…”

Section: -3mentioning

confidence: 99%