Cutaneous lymphomatoid granulomatosis: a rare cause of recurrent skin ulceration

Wood, M.L.; Harrington, C.I.; Slater, David; Rooney, N.; Clark, Anthony

doi:10.1111/j.1365-2133.1984.tb04688.x

Cited by 22 publications

(2 citation statements)

References 12 publications

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“…Typically multifocal and painless, the cutaneous lesions of LG exhibit a number of different clinical patterns including subcutaneous and/or dermal nodules, papules, indurated plaques and macular rashes . A rare case presenting as angioedema has also been described .…”

Section: Discussionmentioning

confidence: 99%

Lymphomatoid granulomatosis presenting with cutaneous involvement: a case report and review of the literature

Rysgaard

Stone

2014

J Cutan Pathol

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Lymphomatoid granulomatosis (LG) is a rare Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorder presenting in middle adulthood that nearly always affects the lungs and shows cutaneous involvement in up to 50% of cases. Skin lesions are present at the time of diagnosis in roughly one-third of patients and may precede the development of lung lesions in as many as 10-15%. Recognition by both the dermatologist and dermatopathologist is therefore crucial for early and accurate diagnosis. While skin involvement is grossly and microscopically diverse, the disease most commonly presents as erythematous subcutaneous and dermal nodules showing the classic histopathologic triad of transmural lymphocytic angiitis, atypical B-lymphocytes in a polymorphous T-cell background, and necrotic foci within lymphoid aggregates. We present a case of lymphomatoid granulomatosis initially presenting with cutaneous lesions, with an accompanying review of the literature.

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Section: Discussionmentioning

confidence: 99%

Lymphomatoid granulomatosis presenting with cutaneous involvement: a case report and review of the literature

Rysgaard

Stone

2014

J Cutan Pathol

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“…Skin involvement in LyG occurs in the form of dermal or sub-cutaneous nodules 85 . One-third of cases show ulceration 181 . More uncommon clinical presentations include plaque-like and lichen sclerosus-like lesions (15% and 10% of cases, respectively) 85 .…”

Section: Lymphomatoid Granulomatosis (Lyg)mentioning

confidence: 99%

Cutaneous EBV-related lymphoproliferative disorders

Gru

Jaffe

2017

Seminars in Diagnostic Pathology

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This article will focus on the cutaneous lymphoproliferative disorders associated with EBV, with an emphasis on the upcoming changes in the revised 4th Edition of the WHO classification of tumors of the hematopoietic system, many of which deal with cutaneous disorders derived from NK-cells or T-cells. Extranodal NK/T-cell lymphoma usually presents in the upper aerodigestive tract, but can involve the skin secondarily. EBV-associated T- and NK-cell lymphoproliferative disorders (LPD) in the pediatric age group include the systemic diseases, chronic active EBV infection (CAEBV) and systemic EBV+ T-cell lymphoma of childhood. Hydroa vacciniforme (HV)-like LPD is a primarily cutaneous form of CAEBV and encompasses the lesions previously referred to as HV and HV-like lymphoma (HVLL). All the T/NK-cell-EBV-associated diseases occur with higher frequency in Asians, and indigenous populations from Central and South America and Mexico. Among the B-cell EBV-associated LPD two major changes have been introduced in the WHO. The previously designated EBV-positive diffuse large B-cell lymphoma (EBV-DLBCL) of the elderly, has been changed to EBV-DLBCL with 'not otherwise specified' as a modifier (NOS). A new addition to the WHO system is the more recently identified EBV+ mucocutaneous ulcer, which involves skin and mucosal-associated sites.

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Cutaneous Lesions of Lymphomatoid Granulomatosis

Miller¹,

Eisen²

1986

Arch Dermatol

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Lymphomatoid granulomatosis is a rare multisystem disease involving the lungs, skin, and nervous system. The cutaneous disease may be the presenting complaint. A case with nodular and annular infiltrated lesions is reported to encourage the inclusion of lymphomatoid granulomatosis in the differential diagnosis of similar lesions. Prompt diagnosis and early long-term treatment with cyclophosphamide and prednisone can lead to prolonged remissions of this disease. If relapse occurs, prompt treatment with the same regimen may again induce a remission.

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Cutaneous lymphomatoid granulomatosis: a rare cause of recurrent skin ulceration

Cited by 22 publications

References 12 publications

Lymphomatoid granulomatosis presenting with cutaneous involvement: a case report and review of the literature

Lymphomatoid granulomatosis presenting with cutaneous involvement: a case report and review of the literature

Cutaneous EBV-related lymphoproliferative disorders

Cutaneous Lesions of Lymphomatoid Granulomatosis

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