Cutaneous manifestations of diabetes mellitus

Perez, Maritza I.; Kohn, Steven R.

doi:10.1016/s0190-9622(94)70058-3

Cited by 175 publications

(119 citation statements)

References 87 publications

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“…Several reports propose that few skin manifestations in diabetic patients may suggest the degree of long-term control of diabetes and are associated with other diabetic complications. 13 Cutaneous manifestations are common in Type I diabetes, like acquired ichthyosis and keratosis pilaris which begin early in the course of the diabetes. Diabetic hands and rubeosis faciei are related to the disease duration.…”

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confidence: 99%

Study of cutaneous manifestations of type 2 diabetes mellitus

Phulari

Kaushik

2018

Int J Res Dermatol

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INTRODUCTIONIn India diabetes mellitus (DM) continues to be a major public health problem, and India is having the highest number of diabetics. 1 DM is a disease with target organs being almost all the parts of body. The changes in the skin are comparable to those occurring in the other internal organs of the body. Many skin disorders show high incidence and severity in DM, the biochemical factors responsible for this are yet to be understood. And according to research, about 30% of diabetic patients will eventually develop cutaneous manifestations during the natural course of this chronic disease. The skin is a temporary reservoir for excess blood glucose which accounts for tendency to develop pruritus and both bacterial and fungal infections. As it is known skin is the largest organ of the body, which is affected by both acute metabolic and the chronic derangements that occur in diabetes. 3Multiple factors have a role in the skin manifestations of DM. According to a study, abnormalities in carbohydrates metabolism, vascular involvement leading ABSTRACT Background: Poorly controlled Type 2 diabetes mellitus (DM) is associated with several disorders and microvascular, macrovascular and neuropathic complications. Multiple factors play a role in the manifestations of cutaneous signs of DM. The prevalence of a cutaneous disorder appears to be similar between Type 1 DM and Type 2 DM patients, but Type 2 DM patients develop more frequent cutaneous infections, and Type 1 DM patients manifest more autoimmune-type cutaneous lesions. The objective of the study was to assess the various cutaneous manifestations of Type 2 DM and the relation of cutaneous manifestations with the duration of Type 2 DM. Methods: All patients of Type 2 DM, of age group 20 and above, of both sexes, attending OPD or IPD at Dr. D. Y. Patil Hospital, Kolhapur willing to give written informed consent, were included for the study between August 2014 -July 2016. Complete history and examination of all the patients with regards to onset of cutaneous manifestations was taken. Results: Majority (49%) of respondents were in the age group of 41 to 60 years, and majority (66%) were males. 57.5% were new cases and 42.5% were known cases. Duration of illness-majority 50.58% were <5 years, 27.05% in 6 to 10 years. In present study there were 61% who had infectious skin manifestations and 39% who had noninfectious skin manifestations. Out of infectious manifestations 39.5% had fungal infection. Conclusions: Therefore on the basis of present study, we conclude that the skin is involved in DM quite often. The manifestations are numerous and varied and many a times they can serve as diagnostic marker for underlying DM. Whenever patients present with multiple skin manifestations, their diabetic status should be checked. The recognition of these skin findings is the key to treatment and prevention.

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confidence: 99%

Study of cutaneous manifestations of type 2 diabetes mellitus

Phulari

Kaushik

2018

Int J Res Dermatol

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“…Chronic illnesses such as systemic lupus erythematosus, scleroderma [48], systemic sclerosis [49], antiphospholipid syndrome [50], connective tissue disease [51], diabetes mellitus [52] and Raynaud's Phenomenon [49] have been readily identified via specific physiological markers at the capillary level such as increased vessel permeability (haemorrhaging) [2,3], the presence of avascular areas, enlarged loops, poor circulation, and increased tortuosity [29]. In addition, the identification of such ailments has not been limited to solely systemic diseases.…”

Section: Clinical Implications Of Blood Flow Assessmentsmentioning

confidence: 99%

‘Go with the flow ’: A review of methods and advancements in blood flow imaging

Daly

Leahy

2012

Journal of Biophotonics

110

108

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Physics has delivered extraordinary developments in almost every facet of modern life. From the humble thermometer and stethoscope to X‐Ray, CT, MRI, ultrasound, PET and radiotherapy, our health has been transformed by these advances yielding both morphological and functional metrics. Recently high resolution label‐free imaging of the microcirculation at clinically relevant depths has become available in the research domain. In this paper, we present a comprehensive review on current imaging techniques, state‐of‐the‐art advancements and applications, and general perspectives on the prospects for these modalities in the clinical realm. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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“…Risk factors are changes in lifestyle like diet, lack of dietary fibres, sedentary lifestyle, alcohol and stress. 2 The cutaneous signs are the manifestations of multiple factors. Abnormal carbohydrate metabolism, other altered metabolic pathways, atherosclerosis, microangiopathy, neuronal degeneration and impaired host mechanism all play an important role.…”

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A Descriptive Study- Cutaneous Manifestations of Diabetes

Nupur¹,

Thakur²,

Yashaswi³

2017

jemds

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BACKGROUNDDiabetes is the most common non-communicable disease globally. Awareness of mucocutaneous manifestations may lead to recognition of yet undiagnosed DM. MATERIALS AND METHODSIt is a descriptive and observational study conducted on 75 diabetic patients. Investigations performed included urine for sugar, protein, fasting and post prandial blood sugar, blood urea, serum creatinine, lipid profile, liver function test and ECG. Special investigations like culture and sensitivity of pus, skin scrapings for fungal infections and biopsy of skin lesion was done in selected cases. Analysis was carried out using SPSS 10. RESULTSOf 75 patients examined, 60 patients (80%) suffered from cutaneous lesions. Some patients suffered from more than one lesion; 50% of total cases suffered from infections. Diabetic dermopathy in our study was observed in 20% of the patients. Some of the cutaneous markers of diabetes mellitus like necrobiosis lipoidica diabeticorum, diabetic bullae, acquired perforating dermatosis and stiff skin syndrome is not seen in our study. CONCLUSIONThis study was done to highlight the importance of association of cutaneous lesions and diabetes mellitus. KEYWORDS BACKGROUNDDiabetes is the most common non-communicable disease globally. It is estimated that nearly 380 million adults worldwide will have diabetes by 2025. Diabetes among adults has reached approximately 20% in urban populations and 10% in rural population. It may be due to genetic defect, autoimmunity, defect in the formation of insulin or decreased insulin sensitivity. It may occur at any age, but greatest number of individuals with Diabetes was aged 45 -64 yrs. 1 DM increases with ageing. Prevalence is slightly greater in men than female. Risk factors are changes in lifestyle like diet, lack of dietary fibres, sedentary lifestyle, alcohol and stress. 2 The cutaneous signs are the manifestations of multiple factors. Abnormal carbohydrate metabolism, other altered metabolic pathways, atherosclerosis, microangiopathy, neuronal degeneration and impaired host mechanism all play an important role. 3 Cutaneous involvement has been found in 43% -66% of diabetic patients approximately. 3 This study was done to highlight the importance of association of cutaneous lesions and diabetes mellitus.

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Cutaneous manifestations of diabetes mellitus

Cited by 175 publications

References 87 publications

Study of cutaneous manifestations of type 2 diabetes mellitus

Study of cutaneous manifestations of type 2 diabetes mellitus

‘Go with the flow ’: A review of methods and advancements in blood flow imaging

A Descriptive Study- Cutaneous Manifestations of Diabetes

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