Cutaneous metastasis: clinicopathological study of 72 patients from a tertiary care center in Lebanon

Abstract

This is, to our knowledge, the first study characterizing the epidemiological, clinical, and histopathological features of cutaneous metastasis in the Lebanese population. The clinical and histopathological features observed were in concordance with the published literature, with minor differences.

Carcinoma erysipeloides mimicking radiation dermatitis – a case report and review of literature

“…Acute radiation dermatitis usually appear during or with in a period of three months after radiotherapy and tend to resolve soon after the completion of treatment [1] Histopathological examination was also not suggestive of flattening or loss of epidermal rete ridges along with edema or sparse connective tissue beneath the epidermis which are the common findings seen in acute radiation dermatitis. Although, as reported, the cutaneous metastasis of breast carcinoma are discovered long after the diagnosis of primary tumor with an average time interval of 2.93 years [9]. In this case, it's diagnosis in early stages can be attributed to a delay in chemotherapy cycles which may have led to early spread of disease to the lymphatics.…”

Lung Sarcomatoid Carcinoma Metastasis to Skin: A Case Report and Review of the Literature

“…The difference may be due to the type of the study that was conducted (25). Pulmonary cancer is the most common cause of cutaneous metastasis and cancer death in men (26), while the laryngeal cancer is found to be most common according to another research (27). A study showed that about 5% of lung carcinoma metastasizes to the skin (28).…”

“…Regarding the histopathology, cutaneous metastasis usually shares features of the primary tumor but may be more undifferentiated (30). Other features such as lymphovascular invasion, necrosis, and a tumor-free "Grenz zone" may also be seen, which can help draw a diagnoses of cutaneous metastasis (27).…”

“…It can mimic an inflammatory dermatosis, or presents as macules, infiltrated or indurated plaques, discoid lesions, tumor nodules with telangiectasias, bullous, or papulosquamous lesions, scarred plaques, or pigmented tumors. But the most common presentation is smooth, firm non-tender nodules, which appears in 80% of the cases (27). The scalp and umbilicus (Sister Mary Joseph nodule) are the most common sites for metastases, although any sites can be involved (31).…”

Metástasis de cáncer de mama en el cuero cabelludo: reporte de 2 casos con diferente presentación clínica

“…En el carcinoma de mama los marcadores para citoqueratina 7 son positivos y para citoqueratina 20 son negativos en la mayoría de los casos 12 . Los marcadores para receptores de estró genos, progestá -genos, mamoglobina, receptor de la proteína-15 del líquido de la enfermedad quística normal y HER2-neu pueden estar postivos 1,13,14 , sin embargo, no es necesaria la positividad de todos para hacer el diagnó stico 1,12 .…”