Lung Sarcomatoid Carcinoma Metastasis to Skin: A Case Report and Review of the Literature

Xu, Xuezhu; Lin, Mao; Wang, Shengyi; Jin, Zeyu; Han, Sanghoon; Liu, Xia; Gao, Yuxue

doi:10.1080/07357907.2016.1193744

Cited by 7 publications

(7 citation statements)

References 32 publications

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“…However, there are several limitations in this retrospective study that should be acknowledged. First, though the common metastatic sites included in the SEER database were the bone, brain, liver and lung, metastases in the heart (28,29), duodenum (30), gingiva (31), and skin (32)(33)(34) have been reported, but not included in the SEER database, thereby underestimating the sample size in this study. Second, metastatic data retrieved from the SEER database were from 2010 to 2016, which may not provide sufficient follow-up time.…”

Section: Discussionmentioning

confidence: 98%

Clinicopathological features and prognostic analysis of metastatic pulmonary sarcomatoid carcinoma: a SEER analysis

et al. 2021

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Background: Pulmonary sarcomatoid carcinoma (PSC) is a rare type of non-small cell lung cancer (NSCLC). Metastases are often detected at the first diagnosis. Despite high rates of distant metastasis, there is insufficient data describing the characteristics of PSC metastasis.Methods: We performed a Surveillance, Epidemiology, and End Results (SEER) database-based analysis of clinicopathological features and prognosis of distant metastasis in PSC patients. Data queried for this analysis included PSC patients in the database between 2010 and 2016. Results: A total of 934 patients met the criteria for inclusion in the analysis and included, at the time of diagnosis, 512 (54.8%) patients with metastasis, including bone (n=152; 16.3%), brain (n=108; 11.6%), liver (n=70; 7.5%), lung (n=142; 15.2%) metastases. Binary logistic regression showed that patients with giant cell carcinoma [odds ratio (OR) 4.023, 95% confidence interval (CI): 2.113-7.661, P<0.001] and spindle cell carcinoma (OR 3.151, 95% CI: 1.699-5.843, P<0.001) were associated with metastasis. Log-rank test and Kaplan-Meier plots indicated poor prognosis in metastatic patients [the 1-, 3-, and 5-year overall survival (OS) rates were 14.1%, 5.5%, and 4.8%, respectively]. Multivariable analysis showed younger and chemotherapy as improved prognostic factors of PSC patients with single metastasis site. Conclusions: The SEER database-based analysis revealed the clinical features of distant metastasis of PSC and showed that different histological types posed distinct metastasis potential. Besides, age and chemotherapy were the independent prognostic factors of PSC patients with single metastasis site.

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Section: Discussionmentioning

confidence: 98%

Clinicopathological features and prognostic analysis of metastatic pulmonary sarcomatoid carcinoma: a SEER analysis

et al. 2021

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“…1 Uncommon metastatic sites includes gastrointestinal tract, 2 right ventricle, 3 mandibular gingiva, 4 tongue 5 and skin. 6 In this case, we found many unsuspected metastatic lesions by PET/CT, especially in the epiglottis. Epiglottis and ileum metastases are extremely rare so that we misjudge it as lymphoma or multiple primary cancers at first.…”

Section: Figurementioning

confidence: 61%

Pulmonary Sarcomatoid Carcinoma With Epiglottis and Ileum Metastasis Detected by 18F-FDG PET/CT

2021

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Pulmonary sarcomatoid carcinoma is a rare subtype of non-small cell lung cancer with poor prognosis. It often metastasizes to lymph nodes, bone, adrenal gland, liver, and brain. Herein, we present a case of a pulmonary sarcomatoid carcinoma patient with epiglottis and ileum metastasis detected by 18 F-FDG PET/CT. Lymphoma or multiple primary cancers with or without regional node metastasis were suspected. Ultimately, histopathology after biopsy revealed pulmonary sarcomatoid carcinoma with epiglottic and ileum metastases. Our case highlights the unique advantages of 18 F-FDG PET/CT in searching for the unsuspected metastasis.

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“…PSC can also metastasize to the upper lip and skin. However, the OS was generally low when PSC metastasized to these unusual organs (16,18,19). Surgery is the main therapeutic method for PSC, especially for early-stage diseases; most patients in our study underwent surgery (8,20,21).…”

Section: Discussionmentioning

confidence: 73%

“…PSC can also metastasize to the upper lip and skin. However, the OS was generally low when PSC metastasized to these unusual organs ( 16 , 18 , 19 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and prognostic factors of pulmonary sarcomatoid carcinoma

Zhao¹,

Gao²,

Xue³

et al. 2022

J Thorac Dis

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Lung Sarcomatoid Carcinoma Metastasis to Skin: A Case Report and Review of the Literature

Cited by 7 publications

References 32 publications

Clinicopathological features and prognostic analysis of metastatic pulmonary sarcomatoid carcinoma: a SEER analysis

Clinicopathological features and prognostic analysis of metastatic pulmonary sarcomatoid carcinoma: a SEER analysis

Pulmonary Sarcomatoid Carcinoma With Epiglottis and Ileum Metastasis Detected by 18F-FDG PET/CT

Clinical characteristics and prognostic factors of pulmonary sarcomatoid carcinoma

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