Cutaneous Protothecosis Presenting as Recurrent Chromomycosis

Cutaneous protothecosis: a case report from Thailand

“…However, there were fewer reports in terms of susceptibility of Prototheca spp. to tetracycline and the results were not as good as with antifungal agents 15,16 …”

“…Even though there is no report of susceptibility of Prototheca spp. to doxycycline, we chose doxycycline as our patient could not tolerate itraconazole, and there were previous reports of successful treatment with tetracycline alone or in combination with amphotericin B 7,8,10,15–18 . Doxycycline is a second generation tetracycline which has the same efficacy and is more beneficial than tetracycline, i.e.…”

Skin Infections

“…1016 The great majority of patients with protothecosis are older than 30 years of age or elderly, although cases have also been reported in children and neonates. 1016,1020,[1023][1024][1025][1026][1027][1028] Lesions resembling herpes, eczema, subcutaneous mycoses, and pyoderma gangrenosum have also been described. 1016 They usually have a slowly progressive course with no tendency to self-heal.…”

Cutaneous protothecosis responds rapidly to voriconazole

“…Protothecosis manifests in three clinical forms as, respectively, cutaneous lesions, olecranon bursitis, and systemic infections . Cutaneous lesions can take various forms and may appear as papules, pustules, nodules, ulcers, vesicles, crusts, atrophic lesions, and verrucous lesions . These often lead to misdiagnosis, which can delay the administration of appropriate treatment for long periods …”