CXC chemokine ligand 16: a Swiss army knife chemokine in cancer

Shabgah, Arezoo Gowhari; Qasim, Maytham T.; Mostafavi, Seyed Mojtaba; Zekiy, Angelina Olegovna; Ezzatifar, Fatemeh; Ahmadi, Majid; Haftcheshmeh, Saeed Mohammadian; Navashenaq, Jamshid Gholizadeh

doi:10.1017/erm.2021.7

Cited by 14 publications

(5 citation statements)

References 83 publications

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“…Because the 16S rDNA exists in this region in all bacteria, an amplified region of around 1250bp was found using the PCR technique, which agreed with the finding of previous studies [26,35]. The isolates identified to the level of strain with the percentage of bacteria isolated from inflammatory smears were Escherichia coli by 20%, Bacillus subtilis by 10%, Enterobacter cancerogenus by 10%, Enterobacter hormaechei by 10%, Enterobacter cloacae by 15%, Klebsiella pneumonia by 15% and Pseudomonas aeruginosa by 20%, which corresponded to past research [36][37][38][39].…”

Section: Sequencing For 16s Rdna and Identification Of Bacterial Speciessupporting

confidence: 91%

Untitled

Jaber¹,

Sayhood²,

Hadi³

et al. 2022

J. Med. Chem. Sci.

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Section: Sequencing For 16s Rdna and Identification Of Bacterial Speciessupporting

confidence: 91%

Untitled

Jaber¹,

Sayhood²,

Hadi³

et al. 2022

J. Med. Chem. Sci.

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“…Follicular helper T cells can promote an immunoactive pancreatic cancer microenvironment by secreting CXCL13 and IL-21 [ 24 ]. Due to a significant correlation between CXC chemokines and immune cells, we hypothesize that some CXC chemokines may serve as important factors leading to immunosuppression in pancreatic cancer [ 25 ]. Furthermore, more experiments should be performed.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of prognostic value and immune infiltration of CXC chemokines in pancreatic cancer

et al. 2022

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Background The prognosis of pancreatic cancer is poor, with a 5-year survival rate of less than 10%. Studies have shown that chemokines in the tumour microenvironment are often altered, which is associated with immune infiltration and the prognosis and survival of pancreatic cancer patients. Methods Multiomics and bioinformatics tools were used to clarify CXC chemokine expression and its role in the pancreatic ductal adenocarcinoma (PDAC) immune microenvironment. Results Most CXC chemokines were upregulated in pancreatic cancer and correlated with patient prognosis. CXC chemokines can activate cancer-related signalling pathways and affect immune infiltration. Furthermore, most CXC chemokines were significantly correlated with the abundance of macrophages, neutrophils and dendritic cells. CXCL5 was selected as a hub gene, and a variety of immune checkpoints, including PD-1/PD-L1 and CTLA-4, were identified. Conclusion Our study provides novel insights into CXC chemokine expression and its role in the PDAC immune microenvironment. These results can provide more data about prognostic biomarkers and therapeutic targets of PDAC.

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“…CXCL16 is an atypical chemokine that exists in a soluble form (sCXCL16) or membraneintegrated form (TM-CXCL16); its cognate receptor, CXCR6, is expressed by T cells [129]. CXCL16/CXCR6 plays a role in T lymphocyte recruitment, retention, and survival within tumor stroma [130][131][132][133].…”

Section: Other Chemokines/receptorsmentioning

confidence: 99%

Immune Cell Migration to Cancer

Ryan,

Kim,

Lim

2024

Cells

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Immune cell migration is required for the development of an effective and robust immune response. This elegant process is regulated by both cellular and environmental factors, with variables such as immune cell state, anatomical location, and disease state that govern differences in migration patterns. In all cases, a major factor is the expression of cell surface receptors and their cognate ligands. Rapid adaptation to environmental conditions partly depends on intrinsic cellular immune factors that affect a cell’s ability to adjust to new environment. In this review, we discuss both myeloid and lymphoid cells and outline key determinants that govern immune cell migration, including molecules required for immune cell adhesion, modes of migration, chemotaxis, and specific chemokine signaling. Furthermore, we summarize tumor-specific elements that contribute to immune cell trafficking to cancer, while also exploring microenvironment factors that can alter these cellular dynamics within the tumor in both a pro and antitumor fashion. Specifically, we highlight the importance of the secretome in these later aspects. This review considers a myriad of factors that impact immune cell trajectory in cancer. We aim to highlight the immunotherapeutic targets that can be harnessed to achieve controlled immune trafficking to and within tumors.

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CXC chemokine ligand 16: a Swiss army knife chemokine in cancer

Cited by 14 publications

References 83 publications

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Untitled

Comprehensive analysis of prognostic value and immune infiltration of CXC chemokines in pancreatic cancer

Immune Cell Migration to Cancer

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