Cyanidin-3-glucoside derived from black soybeans ameliorate type 2 diabetes through the induction of differentiation of preadipocytes into smaller and insulin-sensitive adipocytes

Matsukawa, Toshiya; Inaguma, Tetsuya; Han, Jianzhong; Villareal, Myra O.; Isoda, Hiroko

doi:10.1016/j.jnutbio.2015.03.006

Cited by 87 publications

(67 citation statements)

References 54 publications

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“…C3G has also been shown to improve insulin resistance both in vitro and in vivo . We similarly observed that C3G treatment maintained glucose homeostasis and increased insulin sensitivity in the obese mice.…”

Section: Discussionsupporting

confidence: 65%

Cyanidin‐3‐glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function

You

Yuan

Liu

et al. 2017

Molecular Nutrition Food Res

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Section: Discussionsupporting

confidence: 65%

Cyanidin‐3‐glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function

You

Yuan

Liu

et al. 2017

Molecular Nutrition Food Res

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“…Total RNA isolation and TaqMan real-time PCR amplification reactions were performed as previously described14. For the quantification of gene expression in muscle tissues and C2C12 myotubes, the following specific TaqMan probes purchased from Applied Biosystems (CA, USA) were used: β-actin (Mm00607939_s1), PGC-1α (Mm01208835_m1), PPARδ (Mm00803184_m1), TFAM (Mm00447485_m1), LDHa (Mm01612132_g1), LDHb (Mm01267402_m1), MCT1 (Mm01306379_m1), CPT-1β (Mm00487191_g1), VEGFα (Mm00437306_m1), IGF1 (Mm00439560_m1), and UCP-3 (Mm00494077_m1).…”

Section: Methodsmentioning

confidence: 99%

“…Cyanidin-3-glucoside (Cy3G) is a polyphenol compound that is present in numerous colourful fruits and vegetables, such as black soybean, blueberry and grape12, has many positive health properties. Animal and in vitro model studies have shown that Cy3G has anti-obesity13 and anti-diabetic effects1314. Additionally, the supplementation of red grape leaf extract containing Cy3G has been reported to enhance exercise capacity by activating fatty acid oxidation15.…”

mentioning

confidence: 99%

Upregulation of skeletal muscle PGC-1α through the elevation of cyclic AMP levels by Cyanidin-3-glucoside enhances exercise performance

Matsukawa

Motojima

Sato

et al. 2017

Sci Rep

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Regular exercise and physical training enhance physiological capacity and improve metabolic diseases. Skeletal muscles require peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) in the process of their adaptation to exercise owing to PGC-1α’s ability to regulate mitochondrial biogenesis, angiogenesis, and oxidative metabolism. Cyanidin-3-glucoside (Cy3G) is a natural polyphenol and a nutraceutical factor, which has several beneficial effects on human health. Here, the effect of Cy3G on exercise performance and the underlying mechanisms involved were investigated. ICR mice were given Cy3G (1 mg/kg, orally) everyday and made to perform weight-loaded swimming exercise for 15 days. The endurance of mice orally administered with Cy3G was improved, enabling them to swim longer (time) and while the levels of exercise-induced lactate and fatigue markers (urea nitrogen, creatinine and total ketone bodies) were reduced. Additionally, the expression of lactate metabolism-related genes (lactate dehydrogenase B and monocarboxylate transporter 1) in gastrocnemius and biceps femoris muscles was increased in response to Cy3G-induced PGC-1α upregulation. In vitro, using C2C12 myotubes, Cy3G-induced elevation of intracellular cyclic AMP levels increased PGC-1α expression via the Ca2+/calmodulin-dependent protein kinase kinase pathway. This study demonstrates that Cy3G enhances exercise performance by activating lactate metabolism through skeletal muscle PGC-1α upregulation.

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“…Flavonoids have a wide range of biological functions, including coloration of flowers, protection against ultraviolet radiation and phytopathogens, signaling during nodulation, and auxin transport [90,91]. Dietary flavonoids have been shown to possess an array of pharmacological activities including anti-inflammatory, antithrombotic, antitumor, antiviral, anti-atherosclerotic, antidiabetic, and anti-adipogenic effects [92][93][94][95][96][97][98].…”

Section: Dietary Flavonoidsmentioning

confidence: 99%

Differential effects of dietary flavonoids on adipogenesis

et al. 2018

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Propose Obesity is a fast growing epidemic worldwide. During obesity, the increase in adipose tissue mass arise from two different mechanisms, namely, hyperplasia and hypertrophy. Hyperplasia which is the increase in adipocyte number is characteristic of severe obese patients. Recently, there has been much interest in targeting adipogenesis as therapeutic strategy against obesity. Flavonoids have been shown to regulate several pathways and affect a number of molecular targets during specific stages of adipocyte development. Methods Presently, we provide a review of key studies evaluating the effects of dietary flavonoids in different stages of adipocyte development with a particular emphasis on the investigations that explore the underlying mechanisms of action of these compounds in human or animal cell lines as well as animal models. Results Flavonoids have been shown to regulate several pathways and affect a number of molecular targets during specific stages of adipocyte development. Although most of the studies reveal anti-adipogenic effect of flavonoids, some flavonoids demonstrated proadipogenic effect in mesenchymal stem cells or preadipocytes. Conclusion The anti-adipogenic effect of flavonoids is mainly via their effect on regulation of several pathways such as induction of apoptosis, suppression of key adipogenic transcription factors, activation of AMPK and Wnt pathways, inhibition of clonal expansion, and cell-cycle arrest.

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Cyanidin-3-glucoside derived from black soybeans ameliorate type 2 diabetes through the induction of differentiation of preadipocytes into smaller and insulin-sensitive adipocytes

Cited by 87 publications

References 54 publications

Cyanidin‐3‐glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function

Cyanidin‐3‐glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function

Upregulation of skeletal muscle PGC-1α through the elevation of cyclic AMP levels by Cyanidin-3-glucoside enhances exercise performance

Differential effects of dietary flavonoids on adipogenesis

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