Cyclic AMP, adrenaline and noradrenaline in plasma during surgery

Madsen, S. Nistrup; Fog-Møller, F.; Christiansen, C.; Vester-Andersen, T.; Engquist, A.

doi:10.1002/bjs.1800650315

Cited by 66 publications

(9 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, stress appears to be more strongly related to the rapid and more transient processes (such as rupture of atherosclerotic plaques with subsequent platelet activation, thrombus formation, and vasospasm) that lead to acute coronary syndromes rather than to the long-term atherosclerotic process [34]. On the other hand, treatment with beta-adrenoceptor blocking agents has been shown to effectively reduce the risk of acute coronary syndromes during acute periods of stress, such as surgical stress [35], which is characterized by elevated adrenaline and cAMP levels [36].…”

Section: Discussionmentioning

confidence: 99%

Catechol-O-Methyltransferase Gene Polymorphism Modifies the Effect of Coffee Intake on Incidence of Acute Coronary Events

et al. 2006

View full text Add to dashboard Cite

BackgroundThe role of coffee intake as a risk factor for coronary heart disease (CHD) has been debated for decades. We examined whether the relationship between coffee intake and incidence of CHD events is dependent on the metabolism of circulating catecholamines, as determined by functional polymorphism of the catechol-O-methyltransferase (COMT) gene.Methodology/Principal FindingsIn a cohort of 773 men who were 42 to 60 years old and free of symptomatic CHD at baseline in 1984–89, 78 participants experienced an acute coronary event during an average follow-up of 13 years. In logistic regression adjusting for age, smoking, family history of CHD, vitamin C deficiency, blood pressure, plasma cholesterol concentration, and diabetes, the odds ratio (90% confidence interval) comparing heavy coffee drinkers with the low activity COMT genotype with those with the high activity or heterozygotic genotypes was 3.2 (1.2–8.4). Urinary adrenaline excretion increased with increasing coffee intake, being over two-fold in heavy drinkers compared with nondrinkers (p = 0.008 for trend).Conclusions/SignificanceHeavy coffee consumption increases the incidence of acute coronary events in men with low but not high COMT activity. Further studies are required to determine to which extent circulating catecholamines mediate the relationship between coffee intake and CHD.

show abstract

Section: Discussionmentioning

confidence: 99%

Catechol-O-Methyltransferase Gene Polymorphism Modifies the Effect of Coffee Intake on Incidence of Acute Coronary Events

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Cyclic AMP resulting from adrenergic activation leaks out from cells and, although some breakdown occurs, plasma concentrations of cAMP and epinephrine correlate well in volunteers 11 and during surgery. 12 Therefore, the cAMP response was used as evidence of desensitization of the ␤-adrenergic receptor complex, while attenuation of the effects of epinephrine on serum potassium, blood glucose and heart rate indicated block of either the first or second messenger. [13][14][15] Figure 1 Concentration-time profiles of plasma concentrations of epinephrine, and cAMP, serum concentrations of potassium, insulin and cortisol, blood glucose, and heart rate and mean arterial pressure (MAP) during and after i.v.…”

Section: Discussionmentioning

confidence: 99%

Beta 2-adrenergic responsiveness in vivo during abdominal surgery

Ewaldsson

Hahn

1998

British Journal of Anaesthesia

View full text Add to dashboard Cite

We have studied adrenergic function in vivo during anaesthesia and surgery. Epinephrine 50 ng kg-1 min-1 was given by i.v. infusion over 30 min to 10 healthy adult volunteers and to 10 patients undergoing abdominal operations. The cAMP response to stimulation by epinephrine, which was obtained as the area under the curve (AUC) for plasma cAMP concentration divided by the AUC for plasma concentration of epinephrine, was more pronounced during surgery (mean ratio 3.5) than in the control situation (ratio 1.4; P < 0.02). This resulted in greater hypokalaemic and hyperglycaemic responses (ratios -0.67 and 4.5) than in the control group (ratios -0.33 and 1.6, respectively; P < 0.004). Mean arterial pressure decreased in the control group while it increased in the study group, and serum cortisol concentration was higher in those who underwent surgery (P < 0.02). These results are consistent with an increased adrenergic response during abdominal surgery.

show abstract

“…In man, a correlation between the plasma levels of cAMP and catechol¬ amines has been reported in connection with vari¬ ous types of stress, such as myocardial infarction (Strange et al 1974) and abdominal surgery (Nistrup Madsen et al 1978). A marked elevation of plasma cAMP also occurs following insulin induced hypoglycaemia (Hamet et al 1975;Brodows et al 1976), which is known to lead to marked elevation of plasma catecholamines, primarily adrenaline.…”

Section: Discussionmentioning

confidence: 97%

Plasma cyclic nucleotides and plasma catecholamines before and after prolonged treatment with clonidine in hypertensive patients

Manhem

Hedïng

Malmquist

et al. 1981

Acta Endocrinologica

View full text Add to dashboard Cite

The effect of standing and physical exercise on catecholamines and cyclic nucleotides in plasma was measured in 8 patients with essential hypertension under standardized conditions before and after prolonged treatment with clonidine.Before clonidine medication noradrenaline, adrenaline and cyclic AMP (cAMP) increased in response to standing and bicycling for 20 min. No significant correlation was found between their absolute levels nor was the increase in cAMP following exercise correlated to the increase in noradrenaline. Standing and physical exercise were without effect on cyclic GMP (cGMP). Clonidine reduced the plasma noradrenaline concentration in supine position and the noradrenaline and the adrenaline response to standing and exercise. Plasma cAMP was uneffected by clonidine under basal conditions but the response to exercise was slightly reduced initially. During clonidine there was a positive correlation between the plasma levels of cAMP and noradrenaline following work. Clonidine produced an increase in plasma cGMP in supine position, immediately prior to bicycling and after 5 min of exercise.

show abstract

Cyclic AMP, adrenaline and noradrenaline in plasma during surgery

Cited by 66 publications

References 16 publications

Catechol-O-Methyltransferase Gene Polymorphism Modifies the Effect of Coffee Intake on Incidence of Acute Coronary Events

Catechol-O-Methyltransferase Gene Polymorphism Modifies the Effect of Coffee Intake on Incidence of Acute Coronary Events

Beta 2-adrenergic responsiveness in vivo during abdominal surgery

Plasma cyclic nucleotides and plasma catecholamines before and after prolonged treatment with clonidine in hypertensive patients

Contact Info

Product

Resources

About