Cyclic thioureas (review)

A Chiral Macrocyclic Tetra‐N‐Heterocyclic Carbene Yields an “All Carbene” Iron Alkylidene Complex

“…Compound 2 formed as a white precipitate upon cooling and was collected by filtration. While some depictions of molecule 2 show it as the thiol tautomer, we believe—based on IR evidence (Figure S9) of the broad N−H stretches at 3080 and 3016 cm −1 and no presence of a S−H stretch—that it is primarily the thione form . The cyclic thiourea, 2 , was reduced with excess Raney nickel in refluxing ethanol over seven days to yield (1 S ,2 S )‐1,2‐di(imidazole)cyclohexane, 3 , in 71 % yield.…”

“…While some depictions of molecule 2 show it as the thiol tautomer, [34] we believe-based on IR evi-dence ( Figure S9) of the broad NÀHs tretches at 3080 and 3016 cm À1 and no presence of aS ÀHs tretch-that it is primarily the thione form. [35] The cyclic thiourea, 2,w as reduced with excessR aney nickel in refluxing ethanol over sevend ays to yield (1S,2S)-1,2-di(imidazole)cyclohexane, 3,i n7 1% yield. Other desulfurization reagents such as hydrogen peroxide or benzoyl peroxidew ere ineffective.…”

Precursor reaction kinetics control compositional grading and size of CdSe1−xSx nanocrystal heterostructures

“…The corresponding thiones (S-Im and S-Pym) are synthesized from the N,N 0 -substituted diamines and carbon disulde, thiophosgene, [57][58][59] or thiocarbonyldiimidazole. 59,60 To avoid toxicity concerns, all thiones in this study were prepared from thiocarbonyldiimidazole.…”

“…Similarly, syntheses of S-Pym from N,N 0 -disubstituted-1,3diaminopropanes provided lower yields and must be conducted under dilute conditions to prevent oligomerization. 58 To improve the reproducibility and convenience of the nanocrystal synthesis, 50 gram quantities of cadmium oleate were isolated from cadmium triuoroacetate, triethylamine, and oleic acid in acetonitrile and stored in a nitrogen lled glove box prior to use. In this way, water and/or acetic acid generated during the synthesis of cadmium carboxylates from cadmium oxide or cadmium acetate can be avoided.…”

A review on acridinylthioureas and its derivatives: biological and cytotoxic activity

“…Acridine thioureas and their congeners are important compounds, which play an interesting role in a wide range of organic syntheses of biologically active drugs (Bokatskii et al, 1983;Drobnica et al, 1977;Katritzky et al, 2004;Kurzer, 1952;Maddani & Prabhu, 2010;Mozolis & Iokubaitite, 1973;Mukerjee & Ashare, 1991;Reid, 1963;Schroeder, 1955;Sharma, 1978). Isothioureas, the tautomeric forms of thiourea, are able to enter into cycloaddition reactions with various reagents to form heterocyclic compounds with powerful biological effects (Brown, 1961;Klika et al, 2001;Kristian et al, 1999;Liu et al, 2000;Newcome & Nayak, 1979).…”