Cyclodextrin- and dendrimer-conjugated graphene oxide as a nanocarrier for the delivery of selected chemotherapeutic and photosensitizing agents

Siriviriyanun, Ampornphan; Tsai, Ya-Ju; Voon, Siew Hui; Kiew, Siaw Fui; Imae, Toyoko; Kiew, Lik Voon; Looi, Chung Yeng; Wong, Won Fen; Lee, Hong Boon; Chung, Lip Yong

doi:10.1016/j.msec.2018.04.020

Cited by 35 publications

(17 citation statements)

References 48 publications

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“…Recently, a hybrid material based on graphene oxide (GO) coated with β-cyclodextrin (CD) and poly(amido amine) dendrimer (DEN) was used to deliver doxorubicin, camptothecin (CPT) and a photosensitizer (protoporphyrin IX (PpIX)). The drug loading capacity of hybrid material was in the order of camptothecin > protoporphyrin IX > doxorubicin, and displayed enhanced cytotoxicity [211]. A multi-functional graphene oxide based drug delivery system could target cancerous tissues, and exhibit antitumor effect with no systemic toxicity in B16 tumor-bearing mice [212].…”

Section: Nanomaterials As Drug Delivery Agentsmentioning

confidence: 99%

Current trends and challenges in cancer management and therapy using designer nanomaterials

Navya¹,

et al. 2019

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Nanotechnology has the potential to circumvent several drawbacks of conventional therapeutic formulations. In fact, significant strides have been made towards the application of engineered nanomaterials for the treatment of cancer with high specificity, sensitivity and efficacy. Tailor-made nanomaterials functionalized with specific ligands can target cancer cells in a predictable manner and deliver encapsulated payloads effectively. Moreover, nanomaterials can also be designed for increased drug loading, improved half-life in the body, controlled release, and selective distribution by modifying their composition, size, morphology, and surface chemistry. To date, polymeric nanomaterials, metallic nanoparticles, carbon-based materials, liposomes, and dendrimers have been developed as smart drug delivery systems for cancer treatment, demonstrating enhanced pharmacokinetic and pharmacodynamic profiles over conventional formulations due to their nanoscale size and unique physicochemical characteristics. The data present in the literature suggest that nanotechnology will provide next-generation platforms for cancer management and anticancer therapy. Therefore, in this critical review, we summarize a range of nanomaterials which are currently being employed for anticancer therapies and discuss the fundamental role of their physicochemical properties in cancer management. We further elaborate on the topical progress made to date toward nanomaterial engineering for cancer therapy, including current strategies for drug targeting and release for efficient cancer administration. We also discuss issues of nanotoxicity, which is an often-neglected feature of nanotechnology. Finally, we attempt to summarize the current challenges in nanotherapeutics and provide an outlook on the future of this important field.

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Section: Nanomaterials As Drug Delivery Agentsmentioning

confidence: 99%

Current trends and challenges in cancer management and therapy using designer nanomaterials

Navya¹,

et al. 2019

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“…Innovations in SDDSs field allow the introduction of 2D polymers since they could deliver drug at the appropriate time and site of function and establish a link between therapeutic need and drug delivery [ 123 , 124 ]. To this end, researchers have made use of characteristics of 2D materials polymers, because they can regulate large reversible, physical, or chemical fluctuations as responses to small changes in environmental conditions, such as temperature, light and pH.…”

Section: Encapsulation Of 2d Materialsmentioning

confidence: 99%

Recent advances of two-dimensional materials in smart drug delivery nano-systems

Zhang

Fan

Chen

et al. 2020

Bioactive Materials

144

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Smart drug delivery nano-systems show significant changes in their physical or chemical properties in response to slight change in environmental physical and/or chemical signals, and further releasing drugs adjusted to the progression of the disease at the right target and rate intelligently. Two-dimensional materials possess dramatic status extend all over various scientific and technological disciplines by reason of their exceptional unique properties in application of smart drug delivery nano-systems. In this review, we summarized current progress to highlight various kinds of two-dimensional materials drug carriers which are widely explored in smart drug delivery systems as well as classification of stimuli responsive two-dimensional materials and the advantages and disadvantages of their applications. Consequently, we anticipate that this review might inspire the development of new two-dimensional materials with smart drug delivery systems, and deepen researchers’ understanding of smart nano-carries based on two-dimensional materials.

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“…This expectation comes from the possibility of rearranging specific sets of graphene related properties depending of the implemented strategy. For instance, the modulation of solubility, photosensitivity and load capacity can enhance the efficiency of cancer treatment modalities such as drug delivery 67,68 and phototherapy 69,70 .…”

Section: Gbm In Therapeutic Strategiesmentioning

confidence: 99%

Do biomedical engineers dream of graphene sheets?

et al. 2019

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Cyclodextrin- and dendrimer-conjugated graphene oxide as a nanocarrier for the delivery of selected chemotherapeutic and photosensitizing agents

Cited by 35 publications

References 48 publications

Current trends and challenges in cancer management and therapy using designer nanomaterials

Current trends and challenges in cancer management and therapy using designer nanomaterials

Recent advances of two-dimensional materials in smart drug delivery nano-systems

Do biomedical engineers dream of graphene sheets?

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