Cyclodextrin-based gene delivery systems

Abstract

Cyclodextrin (CD) history has been largely dominated by their unique ability to form inclusion complexes with guests fitting in their hydrophobic cavity. Chemical funcionalization was soon recognized as a powerful mean for improving CD applications in a wide range of fields, including drug delivery, sensing or enzyme mimicking. However, 100 years after their discovery, CDs are still perceived as novel nanoobjects of undeveloped potential. This critical review provides an overview of different strategies to promote interactions between CD conjugates and genetic material by fully exploiting the inside-outside/upper-lower face anisotropy of the CD nanometric platform. Covalent modification, self-assembling and supramolecular ligation can be put forward with the ultimate goal to build artificial viruses for programmed and efficient gene therapy (222 references).

Rapid and efficient pesticide detection via cyclodextrin-promoted energy transfer

“…This solution composition is designed to maximize hydrophobic association between the small molecule aromatic guests and the hydrophobic interior of the cyclodextrin cavity. 26 Experiments in apple juice were conducted by replacing the PBS solution with a 1:1 (v/v) mixture of γ-cyclodextrin in PBS and commercially available apple juice, which used without any purification. The efficiency of energy transfer from the pesticide to the fluorophore was defined according to Equation 1: % Energy transfer = I DA /I A x 100% (Eq.…”

Progress in the Construction ofβ-Cyclodextrin-Fe3O4Supramolecular Systems and Their Application

“…但是, 由于 β-环 糊精及其衍生物均易溶于水, 尤其是在构筑超分子仿酶 催化有机合成领域, 所构筑的超分子仿酶很难回收重复 使用, 需要向反应体系中加入大量丙酮才可以回收 [38] . [44] 、超分子基因输送体系 [45] 、含硒超分子仿酶体 系及其它仿酶体系 [46,47] 、环糊精-卟啉超分子体系 [48] 、 环糊精-石墨烯超分子体系 [49] 、 环糊精超分子组装体 [50] 、 超分子水凝胶体系 [51,52] [112] .…”

Medical Polymer-Based Gene Therapy

“…Cyclodextrins (CDs) are naturally occurring cyclic oligosaccharides composed of (1-4)-linked glucose units arising from enzymatic degradation of starch, which have been approved by the FDA for use as food additives (Mellet, et al, 2011). CDs comprised of 6, 7, and 8 glucose units are called -, -, and -CDs, respectively.…”