Cyclodextrin-Modified Gold Nanospheres

Liu, Jian; Ong, Winston; Román, Esteban; Lynn, Matthew J.; Kaifer, Ángel E.

doi:10.1021/la991519f

Cited by 182 publications

(144 citation statements)

References 12 publications

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“…They have demonstrated that this system can be effectively adapted for colorimetric polynucleotide sequence assays [22]. We have shown that gold colloidal particles [23] and clusters [24] can be derivatized with thiolated cyclodextrins, which retain their molecular complexation properties on the surface of the nanoparticles. Rotello and coworkers have derivatized gold clusters with molecules terminated on hydrogen bonding residues and have demonstrated their binding to complementary solution partners [25].…”

Section: Nanoparticle-based Devicesmentioning

confidence: 99%

Switchable Molecular Devices: From Rotaxanes to Nanoparticles

Liu

Gómez‐Kaifer

Kaifer

2001

Molecular Machines and Motors

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Rotaxanes have been used as molecular frameworks for the preparation of switchable or bistable systems. The properties of a rotaxane that can be switched by electrochemical and chemical means are described in detail and used as an example in this discussion. The advantages of the rotaxane framework compared to systems containing the individual active components mixed together are considered. A series of practical problems hindering the application of single-molecule devices in actual circuits are discussed. Finally, some emerging alternatives to single-molecule devices based on the quickly growing ®eld of metal and semiconductor nanoparticles are brie¯y described.

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Section: Nanoparticle-based Devicesmentioning

confidence: 99%

Switchable Molecular Devices: From Rotaxanes to Nanoparticles

Liu

Gómez‐Kaifer

Kaifer

2001

Molecular Machines and Motors

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“…[24][25][26] The catalytic activities of some water-soluble metal nanoparticles modified with covalently attached CD receptors can be modulated by the inclusion interaction between organometallic compounds and CD, thus catalytic reactions can be carried out effectively. [25,27] Matt and coworkers successfully modified CDs as ligands to form chelate complexes of CD derivatives and transition-metal ions. [8] In recent years, ionic liquids (ILs), which consist of organic cations and appropriate anions, have received much attention due to their potential as a green and recyclable alternative to traditional organic solvents.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Inclusion Complexes of β‐Cyclodextrin with Ionic Liquid

Gao

et al. 2005

Chemistry A European J

139

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The solubilities of beta-cyclodextrin (beta-CD), ionic liquid (IL) 1-butyl-3-methylimidazolium hexafluorophosphate (bmimPF6), and their mixture in water were determined, and the conductivity of these aqueous solutions was measured. It was demonstrated that beta-CD and bmimPF6 could enhance the solubility of each other, and the solubility curves of each were linear with gradients of about 1. The conductivity decreased remarkably with increasing beta-CD concentration, and a discernible break in the conductivity curve could be observed when beta-CD and bmimPF6 were equimolar in the solution. The solubility and conductivity results indicated that inclusion complexes (ICs) of 1:1 stoichiometry were formed. The inclusion compounds were further characterized by using powder X-ray diffraction (XRD) analysis, 13C CP/MAS (cross-polarization magic-angle spinning) NMR and 1H NMR spectroscopy, and thermogravimetric analysis (TGA). The results showed that the ICs were a fine crystalline powder. The host-guest system exhibited a channel-type structure and each glucose unit of beta-CD was in a similar environment. The decomposition temperature of the ICs was lower than that of bmimPF6 and beta-CD individually.

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“…Firstly, β-CD covered AuNPs were synthesized (see the supporting information (SI) available at stacks.iop.org/Nano/ 24/495103/mmedia) [28][29][30][31][32][33]. The resultant particles showed good water solubility and were found to be stable in water for a month.…”

Section: Resultsmentioning

confidence: 99%

Vesicular gold assemblies based on host–guest inclusion and its controllable release of doxorubicin

Kang

Peng

et al. 2013

Nanotechnology

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We have developed a kind of gold nanoparticle (AuNP) in which polyethylene glycol (PEG) and poly(N-isopropylacrylamide) (PNIPAM) are attached on the surface of a gold nanocrystal through the host-guest inclusion between adamantane groups (ADA) and β-cyclodextrin (β-CD). The resulting AuNPs become amphiphilic in water above body temperature and self-assemble into vesicles. It is found that these vesicles can load doxorubicin (Dox) effectively. With a decrease in temperature, the PNIPAM shifted from hydrophobic to hydrophilic, causing Au vesicles to disassemble into stable small AuNPs, triggering the release of Dox. These hybrid vesicles, combining polymer functionality with the intriguing properties of AuNPs, can first release free Dox and AuNP/Dox at a site of a tumor through the application of either simple ice packs or deeply penetrating cryoprobes, then the AuNP/Dox can be taken in by tumor cells and destroy them like miniature munitions. Furthermore, these vesicles showed other therapeutic possibilities due to the presence of gold. We believe that the development of such multi-functional vesicles will provide new and therapeutically useful means for medical applications.

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Cyclodextrin-Modified Gold Nanospheres

Cited by 182 publications

References 12 publications

Switchable Molecular Devices: From Rotaxanes to Nanoparticles

Switchable Molecular Devices: From Rotaxanes to Nanoparticles

Preparation and Characterization of Inclusion Complexes of β‐Cyclodextrin with Ionic Liquid

Vesicular gold assemblies based on host–guest inclusion and its controllable release of doxorubicin

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