Cycloferon efficacy in treatment of upper respiratory tract infections: systematic review and meta-analysis

Mazina, N. K.; Mazin, Pavel; Khafisianova, R Kh

doi:10.17116/otorino20198403182

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…Russian medical journals have published a voluminous corpus of studies on using the antiviral action of Tilorone or Cridanimod for both treatment and prophylaxis (partially reviewed in [ 17 ]). Recent examples are [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Tilorone and Cridanimod Protect Mice and Show Antiviral Activity in Rats despite Absence of the Interferon-Inducing Effect in Rats

et al. 2022

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The synthetic compounds, Tilorone and Cridanimod, have the antiviral activity which initially had been ascribed to the capacity to induce interferon. Both drugs induce interferon in mice but not in humans. This study investigates whether these compounds have the antiviral activity in mice and rats since rats more closely resemble the human response. Viral-infection models were created in CD-1 mice and Wistar rats. Three strains of Venezuelan equine encephalitis virus were tested for the performance in these models. One virus strain is the molecularly cloned attenuated vaccine. The second strain has major virulence determinants converted to the wild-type state which are present in virulent strains. The third virus has wild-type virulence determinants, and in addition, is engineered to express green fluorescent protein. Experimentally infected animals received Tilorone or Cridanimod, and their treatment was equivalent to the pharmacopoeia-recomended human treatment regimen. Tilorone and Cridanimod show the antiviral activity in mice and rats and protect the mice from death. In rats, both drugs diminish the viremia. These drugs do not induce interferon-alpha or interferon-beta in rats. The presented observations allow postulating the existence of an interferon-independent and species-independent mechanism of action.

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Section: Discussionmentioning

confidence: 99%

Tilorone and Cridanimod Protect Mice and Show Antiviral Activity in Rats despite Absence of the Interferon-Inducing Effect in Rats

et al. 2022

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The herbal antiviral remedy Hiporhamin in patients with influenza and acute respiratory viral infections

Kanorsky,

Moisova

2023

Vrach

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Influenza and acute respiratory viral infections annually lead to a seasonal increase in morbidity with disability. Search for effective and safe drugs for their specific treatment is an urgent task. The Russian herbal remedy Hiporhamin has successfully passed the necessary trials for registration as an agent for the treatment of viral infections in adults and children. The distinctive properties of Hiporhamin are broad-spectrum antiviral activity against a number of RNA and DNA viruses, the presence of antimicrobial properties against a number of pathogenic microorganisms, and the established interferon-inducing effect. This set of different properties, including chemotherapeutic activity, effects on different types of pathogens of infectious diseases, and beneficial effects on the macroorganism in the absence of side (toxic) events, provides a wide range of therapeutic efficacy of the drug in the clinic and the possibility of its clinical application in both adults, including pregnant women, and children at the age of 3 years.

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Cycloferon efficacy in treatment of upper respiratory tract infections: systematic review and meta-analysis

Cited by 2 publications

References 2 publications

Tilorone and Cridanimod Protect Mice and Show Antiviral Activity in Rats despite Absence of the Interferon-Inducing Effect in Rats

Tilorone and Cridanimod Protect Mice and Show Antiviral Activity in Rats despite Absence of the Interferon-Inducing Effect in Rats

The herbal antiviral remedy Hiporhamin in patients with influenza and acute respiratory viral infections

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