Cycloplegic Provocative Testing

Harris, Laurence S.; Galin, Miles A.

doi:10.1001/archopht.1969.00990010358010

Cited by 31 publications

(19 citation statements)

References 8 publications

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“…The phenylephrine is used to localize the site of sympathetic denervation in Horner's syndrome, producing mydriasis as part of sympathomimetic action (Smith and Raynard 1992;Ward, 1998). In humans an increase of intraocular pressure (IOP) has been observed after use of topical mydriatics such as atropine (Gartner and Billet, 1957), tropicamide and phenylephrine (Harris 1968;Harris and Galin, 1969;Rengstorff and Doughty, 1982) both in normal subjects and in patients with narrow filtration angle glaucoma (Harris and Galin, 1969) and with primary open angle glaucoma (Shaw and Lewis, 1986;Marchini et al, 2003). Latest report in five years old girl presented to the hospital for a routine retina check-u, after pupil dilation with 1 % tropicamide and 10 % phenylephrine for retinal examination, showed an acute elevation of intraocular pressure (Wu et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Changes in intraocular pressure and horizontal pupil diameter during use of topical mydriatics in the canine eye

Kovaļčuka¹,

Ilgazs²,

Bandere³

et al. 2017

Open Vet J.

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The objective of this study was to determine the effects of topical 0.5% tropicamide, 1% atropine sulphate and 10% phenylephrine hydrochloride ophthalmic solutions on intraocular pressure (IOP) and horizontal pupil diameter (HPD) in the dog during the first hour after treatment. Forty clinically and ophthalmologically normal canine patients (between the ages of 2 and 6 years) of varying breed and sex were used in this study. Animals were randomly divided into four groups of ten and given one drop of tropicamide, atropine, phenylephrine or saline into one eye. IOP and HPD were measured in both eyes every 5 minutes for 60 minutes. Tropicamide increased IOP by 8.8±4.0 mmHg 35 minutes post-treatment compared to pre-treatment (P<0.01) only in treated eye. IOP in the contralateral eye did not increase. With atropine the maximum increase in IOP was 2.6±2.8 mmHg at 20 minutes post treatment in the treated eye (P<0.01). IOP in the contralateral eye did not increase. Phenylephrine increased IOP by 2.3±2.1 mmHg (P<0.05) 10 minutes after treatment. Also in the untreated eye IOP increased by 2.3±2.1 mmHg, 20 minutes post-treatment. Maximum HPD in eyes treated with tropicamide occurred at 55 minutes and with atropine at 60 minutes. There were no HPD changes in the contralateral, untreated eye. Topical 10% phenylephrine showed maximal pupil dilation 60 minutes after treatment, but the HPD of the -untreated eye slightly decreased at 15 minutes, but this change only reached statistical significance at 40 min post-treatment (P<0.05). Normal saline showed no influence on IOP or HPD. The drugs investigated here show a significant increase in IOP after mydriatics.

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Section: Introductionmentioning

confidence: 99%

Changes in intraocular pressure and horizontal pupil diameter during use of topical mydriatics in the canine eye

Kovaļčuka¹,

Ilgazs²,

Bandere³

et al. 2017

Open Vet J.

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“…1,2 Additional adjunctive tests may include the dilatation provocative tests 3 and topical steroid response. 1 Recent studies indicate Ibopamine may be helpful in evaluating glaucoma [4][5][6][7][8] Ibopamine (3,4 di-isobutyrylester of N-methyldopamine) 2% eyedrops are hydrolyzed to epinine, an analogue of dopamine.…”

Section: Introductionmentioning

confidence: 99%

Ibopamine provocative test and glaucoma: Consideration of factors that may influence the examination

Magacho

Lima

Costa

et al. 2004

Current Eye Research

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“…Vários testes foram estudados como indicadores prognósticos do glaucoma, como os testes de sobrecarga hídrica (1)(2) , testes provocativos de midríase (3) e ensaios terapêuticos (4) . Como o glaucoma é uma doença silenciosa que pode levar à cegueira irreversível se não tratado, a iniciativa de buscar testes indicativos de glaucoma com boa eficácia é justificado.…”

Section: Resumo Introduçãounclassified