Cyclosporine A-loaded drug delivery systems inhibit scar formation after glaucoma surgery in rabbits

Dai, Zhaoxing; Song, Xiaole; Yu, Xiaoling; Sun, Jianguo; Sun, Xinghuai

doi:10.1097/cm9.0000000000000234

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Recent in vivo studies with different delivery methods and concentrations have supported this data [ 174 , 175 ]. However, 2% cyclosporine intraoperatively and postoperatively was not associated with IOP or prolonged bleb survival in rabbits when compared with MMC [ 176 ]. In human clinical trials, topical 0.05% cyclosporine was shown to have no effect on postoperative bleb function or IOP following trabeculectomy, although there was a decrease in ocular surface disease [ 177 ].…”

Section: Strategies To Prevent Ocular Fibrosis Following Glaucoma Fil...mentioning

confidence: 99%

Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery

et al. 2023

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Conjunctival fibrosis remains the major impediment to the success of glaucoma filtration surgery. Anti-metabolites remain the gold standard for mitigating post-surgical fibrosis, but they are associated with high complication rates and surgical failure rates. Establishing a more targeted approach to attenuate conjunctival fibrosis may revolutionize the surgical approach to glaucoma. A new strategy is needed to prevent progressive tissue remodeling and formation of a fibrotic scar, subsequently increasing surgical success and reducing the prevalence of glaucoma-related vision loss. Advancements in our understanding of molecular signaling and biomechanical cues in the conjunctival tissue architecture are broadening the horizon for new therapies and biomaterials for the mitigation of fibrosis. This review aims to highlight the strategies and current state of promising future approaches for targeting fibrosis in glaucoma filtration surgery.

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Section: Strategies To Prevent Ocular Fibrosis Following Glaucoma Fil...mentioning

confidence: 99%

Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery

et al. 2023

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PLA-PEG Implant as a Drug Delivery System in Glaucoma Surgery: Experimental Study

et al. 2022

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Excessive postoperative scarring halts the effectiveness of glaucoma surgery and still remains a challenging problem. The purpose of this study was to develop a PLA-PEG-based drug delivery system with cyclosporine A or everolimus for wound healing modulation. Methods: PLA-PEG implants saturation with cyclosporine A or everolimus as well as their further in vitro release were analyzed. Anti-proliferative activity and cytotoxicity of the immunosuppressants were studied in vitro using human Tenon’s fibroblasts. Thirty-six rabbits underwent glaucoma filtration surgery with the application of sham implants or samples saturated with cyclosporine A or everolimus. The follow-up period was six months. A morphological study of the surgery area was also performed at seven days, one, and six months post-op. Results: PLA-PEG implants revealed a satisfactory ability to cumulate either cyclosporine A or everolimus. The most continuous period of cyclosporine A and everolimus desorption was 7 and 13 days, respectively. Immunosuppressants demonstrated marked anti-proliferative effect regarding human Tenon’s fibroblasts without signs of cytotoxicity at concentrations provided by the implants. Application of PLA-PEG implants saturated with immunosuppressants improved in vivo glaucoma surgery outcomes. Conclusions: Prolonged delivery of either cyclosporine A or everolimus by means of PLA-PEG implants represents a promising strategy of wound healing modulation in glaucoma filtration surgery.

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Cyclosporine A-loaded drug delivery systems inhibit scar formation after glaucoma surgery in rabbits

Cited by 2 publications

References 8 publications

Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery

Novel Therapies for the Prevention of Fibrosis in Glaucoma Filtration Surgery

PLA-PEG Implant as a Drug Delivery System in Glaucoma Surgery: Experimental Study

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