Cyclosporine and psoriasis: 2008 National Psoriasis Foundation Consensus Conference

Cyclosporin A Production from Tolipocladium inflatum

“…• Causes metabolic alterations in liver, muscle and adipose tissue, which may contribute to the development of dyslipidemia and insulin resistance [19] • Acute kidney injury • Hyperlipidemia (especially hypertriglyceridemia) • Hypertension • Gastrointestinal upset and headaches [20] • Hypertrichosis [21] • Increase testosterone level [22] • Gingival overgrowth [23] …”

Psoriasis Vulgaris: An Evidence-Based Guide for Primary Care

“…53 During a complete history the patient should be asked about anything that would increase their risk of nephrotoxcity, such as obesity, diabetes mellitus, advanced age, and concomitant use of nephrotoxic drugs. 52 Exercise caution when dealing with patients taking multiple drugs because CsA has numerous drug-drug interactions due to its metabolism by the cytochrome p450 34A system or when administering with foods like grapefruit juice. 33,76 During the complete physical examination at baseline and at each monthly visit, patients should be evaluated for skin neoplasms or infections because CsA increases the risk for developing squamous and basal cell carcinomas.…”

“…33,76 During the complete physical examination at baseline and at each monthly visit, patients should be evaluated for skin neoplasms or infections because CsA increases the risk for developing squamous and basal cell carcinomas. 52 In addition, at baseline, all patients initiating CsA should undergo routine age-appropriate cancer screening. 52 Testing for tuberculosis and hepatitis C at baseline is advisable.…”

“…52 In addition, at baseline, all patients initiating CsA should undergo routine age-appropriate cancer screening. 52 Testing for tuberculosis and hepatitis C at baseline is advisable. 52 Because CsA is immunosuppressive, vaccines may be helpful, and booster vaccination may be necessary; however, live vaccines are contraindicated with use of CsA.…”

“…52 Testing for tuberculosis and hepatitis C at baseline is advisable. 52 Because CsA is immunosuppressive, vaccines may be helpful, and booster vaccination may be necessary; however, live vaccines are contraindicated with use of CsA.…”