1993
DOI: 10.1097/00006534-199301000-00013
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Cyclosporine for Pyoderma Gangrenosum

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1993
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Cited by 20 publications
(7 citation statements)
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“…However, it was reported that steroids may interfere with postoperative wound healing, and nowadays the introduction of therapy with cyclosporin A has offered an alternative treatment in cases of PG after cardiothoracic surgery, particularly within the first eight postoperative weeks before healing of the sterna bone is completed. Considering the cases of PG following cardiac surgery, Goldberg et al 2 and Koss‐Harnes et al 3 reported a single case patient who had undergone coronary bypass grafting followed by PG that was treated successfully with cyclosporine and steroids; our experience is consistent with these previous cases, reporting a complete healing of the ulcerated wound with solely the steroids administration.…”
Section: Discussionsupporting
confidence: 84%
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“…However, it was reported that steroids may interfere with postoperative wound healing, and nowadays the introduction of therapy with cyclosporin A has offered an alternative treatment in cases of PG after cardiothoracic surgery, particularly within the first eight postoperative weeks before healing of the sterna bone is completed. Considering the cases of PG following cardiac surgery, Goldberg et al 2 and Koss‐Harnes et al 3 reported a single case patient who had undergone coronary bypass grafting followed by PG that was treated successfully with cyclosporine and steroids; our experience is consistent with these previous cases, reporting a complete healing of the ulcerated wound with solely the steroids administration.…”
Section: Discussionsupporting
confidence: 84%
“…Generally, PG mainly affects adults who are between 25 and 54 years old, and is frequently associated with a systemic inflammatory disease (e.g., inflammatory bowel disease, rheumatoid arthritis, chronic active hepatitis) or immunodeficiency (leukemia, infection with the human immunodeficiency virus, monoclonal gammopathy of the IgA type); it also may occur in healthy people and can develop following trauma or an operative procedure 9‐14 . In particular, PG after cardiac operation have been rarely reported so far 1‐3,5,15,16 . Reviewing the available published data, less than 10 cases have been specifically reported, and similar to previous data our cardiac‐operated patient was found to have a systemic immune disease consisting of a monoclonal gammopathy with IgG/k chains (Table 1).…”
Section: Discussionmentioning
confidence: 99%
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“…Some continued to use small doses of cyclosporine for a long time after wound healing, 11,12 and some others discontinued the drug soon after healing. 5,6 We think that it would depend on the nature of combined systemic diseases. If the systemic diseases are hard to control but responsive to cyclosporine, like ulcerative colitis, it is wise to maintain low dose of cyclosporine for a long time.…”
Section: Discussionmentioning
confidence: 99%