Cyclosporine is associated with endothelial dysfunction but not with platelet activation in renal transplantation

Schrama, Yvonne C.; Dam, Thea van; Fijnheer, Rob; Hené, Ronald J.; Groot, Philip de; Rabelink, Ton J.

doi:10.1016/s0300-2977(01)00127-9

Cited by 22 publications

(11 citation statements)

References 30 publications

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“…In accordance with our results, Schrama et al [33] showed that endothelial damage in renal transplant patient was not accompanied by platelet activation or increased reactivity. Using flow cytometric methods, these authors investigated platelet CD62P expression ex vivo during treatment with CyA and after its withdrawal, and also after incubation of blood platelets with different CyA concentrations, i.e., 0.2, 20, and 200 ng/l.…”

Section: Discussionsupporting

confidence: 94%

“…Since the data are conflicting, we postulate that the enalapril therapy (in 5 of 16 CyAtreated patients) had an insignificant influence on the results of our study. Previous studies assessing the influence of CyA on platelet function have produced controversial results [15,16,17,18,19,31,32,33]. To date, the influence of immunosuppressive therapy on platelet function in renal transplant recipients has been most widely studied [15,33].…”

Section: Discussionmentioning

confidence: 99%

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Cyclosporin A does not affect platelets in children with idiopathic nephrotic syndrome

2004

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The immunosuppressive agents administered to maintain the remission of idiopathic nephrotic syndrome (INS) may have a deleterious effect on several cell types. The aim of this study was to analyze platelet activation and reactivity in children with INS treated with cyclosporin A (CyA). The study groups comprised 16 children with remission of INS induced by CyA and 16 children with glucocorticosteroid-induced remission 8 weeks from the onset of INS relapse. Fifteen healthy children served as controls. Surface expression of CD61, CD62P, and CD42b on resting and thrombin-stimulated platelets was analyzed with flow cytometry. No differences between groups were found in CD61, CD62P, and CD42b surface expression, but markers of the coagulation cascade and fibrinolysis or endothelial injury (F1+2 prothrombin fragments, tissue plasminogen activator inhibitor 1) were elevated in patients treated with CyA compared with children on steroids and healthy controls. No correlations between markers of platelet function and CyA concentration were found. We postulate that CyA administration in nephrotic patients causes an activation of thrombinogenesis but does not influence platelet activation and reactivity in INS.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Cyclosporin A does not affect platelets in children with idiopathic nephrotic syndrome

2004

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“…45 In addition, cyclosporine has been linked to increased sympathetic tone, new-onset hypertension, and peripheral vasoconstriction in HTx recipients. 46 These effects may, at least in part, be mediated by free radicals. 22 Our data provide further support for the idea that long-term cyclosporine exposure contributes to endothelial dysfunction as ~75% of the > 14 yrs post-HTx recipients were currently taking cyclosporine (Table 2) and there was a tendency for ET-1 levels to be increased in this group.…”

Section: Discussionmentioning

confidence: 99%

Vascular Function and the Role of Oxidative Stress in Heart Failure, Heart Transplant, and Beyond

et al. 2012

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Using flow-mediated vasodilation (FMD), reactive hyperemia (RH), and an acute oral antioxidant cocktail (AOC [Vitamin C, E and α-lipoic acid]), this study aimed to provide greater insight into altered vascular function and the role of oxidative stress in chronic heart failure patients with reduced ejection fraction (HFrEF) and at several time points beyond heart transplantation (HTx). A total of 61 age-matched subjects (12 healthy controls, 14 NYHA Class II and III HFrEF patients, and 35 HTx recipients (< 3 yrs post-HTx, 5-10 yrs post-HTx, and > 14 yrs post-HTx)) ingested either placebo (PL) or an AOC prior to FMD and RH testing of the brachial artery. Vascular function, as measured by FMD, was not different between the controls (6.8 ± 1.9 %), recent < 3 yrs post-HTx group (8.1 ± 1.2%), and the 5-10 yrs post-HTx group (5.5 ± 1.0%). However, PL FMD was lower in the HFrEF patients (4.5 ± 0.7%) and in the > 14 yrs post-HTx group (2.9 ± 0.8%). The AOC increased plasma ascorbate levels in all groups, but only increased FMD in the controls (PL 6.8 ± 1.9%; AOC 9.2 ± 1.0%) and > 14 yrs post-HTx recipients (PL 2.9 ± 0.8%; AOC 4.5 ± 1.3%). There were no differences in RH in any of the groups with PL or AOC. This cross-sectional study reveals that, compared to controls, vascular function is blunted in HFrEF patients, is similar soon after HTx, but is decreased with greater time post-HTx with free radicals implicated in this progression.

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“…Schrama et al . reported that withdrawal of CsA was accompanied by a dose‐related decrease in both Von Willebrand Factor (VWF) and soluble P‐selectin demonstrating that the use of CsA was not accompanied by platelet activation, but induced ED as reflected by increased VWF and soluble P‐selectin . In their study, Malyszko et al .…”

Section: Discussionmentioning

confidence: 99%

Association between endothelial and platelet function markers and adiponectin in renal transplanted recipients on cyclosporine and tacrolimus immunosuppression based therapy

et al. 2015

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Cyclosporine is associated with endothelial dysfunction but not with platelet activation in renal transplantation

Cited by 22 publications

References 30 publications

Cyclosporin A does not affect platelets in children with idiopathic nephrotic syndrome

Cyclosporin A does not affect platelets in children with idiopathic nephrotic syndrome

Vascular Function and the Role of Oxidative Stress in Heart Failure, Heart Transplant, and Beyond

Association between endothelial and platelet function markers and adiponectin in renal transplanted recipients on cyclosporine and tacrolimus immunosuppression based therapy

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