Cyflumetofen, a novel acaricide – its mode of action and selectivity

Abstract

The mode of action of cyflumetofen is to inhibit mitochondria complex II by affecting its action site after being metabolised to AB-1. However, inhibition by cyflumetofen and AB-1 in other organisms was very weak. Selectivity for other organisms has contributed to differences in action site activities.

Synthesis and biological activity of a novel acaricide, pyflubumide

“…Furthermore, our study revealed that pyflubumide-deisobutylated metabolite 9 inhibits electron transport in mitochondrial complex II of spider mites, as with the cases of beta-ketonitrile acaricides. 21,22) However, it was also suggested that their binding sites on mitochondrial complex II and/ or the manners of binding are not identical. 20,23,24) These results demonstrate that pyflubumide could be a promising new acaricide.…”

The economic importance of acaricides in the control of phytophagous mites and an update on recent acaricide mode of action research

“…Cyflumetofen provides rapid knockdown of spider mites pest through contact activity, typically within 3 hours after application, and has been observed to control mite populations up to 28 days after application [91]. Cyflumetofen and cyenopyrafen both interfere with mitochondrial electron transport, but contrary to METIs (Complex I inhibitors) and bifenazate and acequinocyl (Complex III inhibitors, see section 3.2), these compounds inhibit complex II of mitochondrial electron transport chain [86,93]. Recently it was also reported that both cyenopyrafen and cyflumetofen are pro-acaracides that need bio-activation by hydrolysis [86,93].…”

“…during all life stages, although some highly multi-resistant T. urticae strains might show cross-resistance [85]. Moreover, they do not affect a variety of non-targeted arthropod species [86][87][88][89][90][91] and can be integrated in IPM programs. In addition to its efficacy in spider mite control, cyflumetofen also seems to be a promising tool for effective control of Brevipalpus sp.…”

Mode of action of novel acaricide pyflubumide: Effects on the mitochondrial respiratory chain

“…The most recently developed class of acaricides are mitochondrial complex II (succinate-quinone oxidoreductase) inhibitors, such as cyenopyrafen. [10][11][12] For resistance management and effective and sustainable use of these compounds, it is important to execute a resistance-management strategy through rotating acaricides with differing modes of action. 13) Pyflubumide is a novel and potent acaricidal compound that was developed by Nihon Nohyaku Co., Ltd. (R=COCH(CH 3 ) 2 , Fig.…”