The medicinal plant Sphagneticola trilobata native to South America is used in local folk medicine to
treat inflammation and analgesics. In present study, gastroprotective effects of methanolic extracts of
S. trilobata leaves and stem were investigated in indomethacin-induced gastric ulcers in rats at doses
of 200 mg/kg for leave extract and 350 mg/kg for stem extract. Indomethacin produced stomach
ulcers and increased neutrophil percentage and MDA levels compared to the control group (p < 0.001).
Co-administration of indomethacin and omeprazole, methanolic extracts of leaves (200 mg/kg) (p <
0.001) and methanolic extracts (350 mg/kg) (p < 0.05) of stem compared to indomethacin group to
ulcers was low (p < 0.001). Methanolic extracts (200 mg/kg) of leaves and methanolic extracts (350
mg/kg) of stem reduced MDA levels (p < 0.001). Methanolic extracts (200 mg/kg) of leaves and
methanolic extracts (350 mg/kg) of the stem significantly decreased neutrophil percentage compared
to indomethacin group (p < 0.001). The results suggest that the methanolic extracts of Sphagneticola
trilobata leaves and stem have a protective effect on indomethacin-induced gastric ulcers.