Cyst sclerotherapy with minocycline hydrochloride in patients with autosomal dominant polycystic kidney disease

Uemasu, Jiro; Fujihara, M.; Munemura, Chishio; Nakamura, Ernani J.; Kawasaki, Hironaka

doi:10.1093/oxfordjournals.ndt.a027410

Cited by 19 publications

(17 citation statements)

References 5 publications

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“…Several agents have been used to destroy the cyst wall epithelium, including ethanol (13-16), minocycline hydrochloride (6, 7), povidone-iodine (17), acetic acid (18), and ethanolamine oleate (19); of these various sclerosants, absolute ethanol was used in the present study. This rapidly inactivates the secreting cells of the cysts, and because it is very slow to penetrate the fibrous cystic capsule, can be removed before the renal parenchyma is affected (14).…”

Section: Discussionmentioning

confidence: 99%

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Ablation of Symptomatic Cysts Using Absolute Ethanol in 11 Patients with Autosomal-Dominant Polycystic Kidney Disease

Lee

2003

Korean J Radiol

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ObjectiveTo evaluate the effects of cyst ablation with absolute ethanol in autosomal-dominant polycystic kidney disease (ADPKD) patients with symptomatic cysts.Materials and MethodsUsing absolute ethanol, cyst ablation was performed in 11 patients with documented ADPKD who suffered cyst pain refractory to medical treatment. An ethanol solution was instilled into the largest symptomatic cysts through a catheter. We assessed the therapeutic efficacy of the procedure by tracking subjective pain relief during a 3 to 24-month follow-up period after ablation.ResultsAt follow-up, we found that the duration of subjective pain relief was 12 to 24 months in seven patients, 4 to11 months in one, and less than 3 months in three.ConclusionSelective ablation of a symptomatic cyst may be a valid option in managing chronic pain caused by one or a few large cysts in ADPKD patients.

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Section: Discussionmentioning

confidence: 99%

“…Percutaneous sclerotherapy may be difficult in ADPKD, due to the presence of multiple cysts and the difficulty in identifying those which cause pain, selective ablation is, however, effective for the management of chronic pain caused by one or a few large cysts (5, 6). …”

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confidence: 99%

Ablation of Symptomatic Cysts Using Absolute Ethanol in 11 Patients with Autosomal-Dominant Polycystic Kidney Disease

Lee

2003

Korean J Radiol

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“…Of these, ethanol is the most widely used because it is considered to be safer and more effective than the other drugs (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The present study used 99% ethanol.…”

Section: Discussionmentioning

confidence: 99%

Predictors of the Frequency of Ethanol Injections for Renal Cyst Ablation: A Preliminary Study

Kim

Cho

2018

J Korean Soc Radiol

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Purpose:To assess the factors facilitating the prediction of the frequency of ethanol injections in successful renal cyst ablation. Materials and Methods:We retrospectively reviewed the computed tomography and ultrasonography scans of 37 renal cysts. Two radiologists evaluated the characteristics of the presenting renal cysts, including size, calcification, septation, and lobulated configuration. Patients were divided into an "above-four" group and "below-three" group, according to the number of ethanol injections. Results: Among the 37 renal cysts, six belonged to the "above-four" group and 31 to the "below-three" group. The mean volume of "above-four" group was 409.48 cc and that of the other group was 301.64 cc. Seven renal cysts included three belonging to the "above-four" group, which showed calcification. Twelve renal cysts presented a multilocular appearance with thin septa, and included a cyst classified under the "above-four" group. Three renal cysts had lobulated configuration, with one of them belonging to the "above-four" group. Conclusion: No significant correlation was found among the different factors in the prediction of the frequency of renal cyst ablation. However, calcification was the most useful parameter for prediction of the number of renal cyst ablations needed.

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“…A low concentration of MINO (1 to 2 mg/mL) is usually injected intravenously. MINO injection has been used to treat renal cysts [66][67][68] , splenic cysts [69] , thyroid cysts [70] , and hepatic cysts [26,27,38,[41][42][43] . MINO 100 mg/mL was injected to treat thyroid cysts [70] , and MINO 10 mg/ mL [66] was instilled into renal cysts.…”

Section: Discussionmentioning

confidence: 99%

“…MINO injection has been used to treat renal cysts [66][67][68] , splenic cysts [69] , thyroid cysts [70] , and hepatic cysts [26,27,38,[41][42][43] . MINO 100 mg/mL was injected to treat thyroid cysts [70] , and MINO 10 mg/ mL [66] was instilled into renal cysts. Concentrations of MINO that have been used to manage hepatic cysts range from 5 to 50 mg/ mL [26,27,38,[41][42][43] .…”

Section: Discussionmentioning

confidence: 99%

Repeated Minocycline Hydrochloride Injections for Symptomatic Polycystic Liver Disease

Yoshida

Makino

Yokoyama

et al. 2016

Journal of Gastroenterology and Hepatology Research

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AIM:The present study evaluated the safety and effectiveness of repeated injections of minocycline hydrochloride (MINO) for symptomatic polycystic liver disease (PLD). METHODS:We retrospectively studied patients who received percutaneous MINO injections for symptomatic PLD and were followed up for at least 2 years between 2002 and 2015. Huge hepatic cysts (diameter > 10 cm) were treated by continuous drainage and multiple MINO injections. Small hepatic cysts underwent one-step drainage followed by a single injection of MINO. Only several cysts that caused complications were treated by percutaneous injection of MINO. Patients were discharged 1 day after treatment. RESULTS: Ten patients, (4men and 6 women; mean age, 57.8 years) were studied. All patients had Type 2 PLD according to Gigot's classification. The chief complaints were abdominal distension (n = 10), abdominal pain (n = 6), back pain (n = 4), and appetite loss (n = 8). Four patients had mild liver dysfunction. One patient complained of moderate right subscapular pain immediately after the injection, and another had pain at the site of catheter insertion. Liver dysfunction did not develop in any patient after treatment. The mean follow-up was 63.4 months. The interval from the first to last admission for MINO injection therapy was 14 to 148 months (mean, 40.8 months). The number of admissions for MINO injection therapy ranged from 2 to 12 times (mean, 4.0 times). The average interval for MINO injection therapy was 8.3 to 19 months (mean, 14.8 months).The hepatic cysts shrank in all patients after treatment. Complications improved consistently, and all patients were satisfied with the outcome of treatment. CONCLUSIONS: Symptomatic PLD was controllable by 14.8 months of repeated MINO injections on average. Repeated MINO injections are a safe, definitive treatment for symptomatic PLD.

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Cyst sclerotherapy with minocycline hydrochloride in patients with autosomal dominant polycystic kidney disease

Abstract: These results suggest that cyst sclerotherapy with minocycline hydrochloride is a valid treatment regime for the relief of chronic symptoms in ADPKD cases, although repeated application of this approach may be required to obtain a more long-term effect.

Cited by 19 publications

References 5 publications

Ablation of Symptomatic Cysts Using Absolute Ethanol in 11 Patients with Autosomal-Dominant Polycystic Kidney Disease

Ablation of Symptomatic Cysts Using Absolute Ethanol in 11 Patients with Autosomal-Dominant Polycystic Kidney Disease

Predictors of the Frequency of Ethanol Injections for Renal Cyst Ablation: A Preliminary Study

Repeated Minocycline Hydrochloride Injections for Symptomatic Polycystic Liver Disease

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