Cystic lesions of the head and neck: cytohistological correlation in 63 cases

Firat, Pınar; Ersöz, Canan; Uğuz, Aysun; Önder, Sevgen

doi:10.1111/j.1365-2303.2006.00400.x

Cited by 27 publications

(28 citation statements)

References 16 publications

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“…20,21 In our series, the benign lesions also conformed to the known rates and frequencies as described elsewhere. 1,13 Although others have experienced false-positive malignant diagnoses, we did not have any in this series. 1,13,15 One observation, however, was made with the false-negative episodes.…”

Section: Discussionmentioning

confidence: 49%

“…1,13 Although others have experienced false-positive malignant diagnoses, we did not have any in this series. 1,13,15 One observation, however, was made with the false-negative episodes. Among the cases with a non specific FNA diagnosis, there was a 30% chance of a malignant lesion that had been missed by the fine-needle aspiration method.…”

Section: Discussionmentioning

confidence: 49%

“…These investigators have shown a sensitivity of 70% and the specificity of 96% in their series. 1 Therefore, in ours as well as the studies by others, it has become evident that although FNA procedure on the cystic lesions yields a very high specific result, its lower sensitivity (70-75%) warrants caution when a benign diagnosis is rendered. The main role of fine-needle aspiration is to differentiate malignant from benign lesions and triage the cases.…”

Section: Discussionmentioning

confidence: 87%

“…We should express that the diagnostic accuracy of the FNA is also dependent on the location of the mass, type of the lesion, and the expertise of both aspirator and cytopathologist as expressed by others as well. 1,15 Because of the small number of the cases performed by the radiologists in this series, future studies should determine if there is a difference in sensitivity between ultrasound-guided versus palpation-guided FNA.…”

Section: Discussionmentioning

confidence: 95%

“…The main goal of the FNA is to determine the presence or absence of a neoplasm, assure the clinical benign impression of the mass, and if malignant, to determine the type of malignancy. 1,2 In a nutshell, FNA findings aid the clinicians in initial evaluation of the lesion for taking subsequent steps in treating the lesions and managing the patients. Although the FNA has a high diagnostic accuracy, several problems may arise, primarily affecting the sensitivity of the technique.…”

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confidence: 99%

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A correlation study of diagnostic fine‐needle aspiration with histologic diagnosis in cystic neck lesions

Moatamed

Naini

Fathizadeh

et al. 2009

Diagnostic Cytopathology

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The clinical diagnosis of a mass in the neck region encompasses a wide spectrum of differential diagnosis. Fine-needle aspiration is a quick and safe technique, which can provide useful information for initial assessment and further therapeutic measures. The aim of this retrospective study was to evaluate the performance characteristics of the fine-needle aspiration (FNA) in cystic neck lesions. Of 142 patients with FNA for cystic neck masses during 2002-2007, 92 cases were selected with a follow-up histologic diagnosis, excluding the cystic colloid nodule of the thyroid. The cases were divided into salivary gland cystic neck (37 patients) and non-salivary cystic neck (55 patients) mass groups. False-positive and false-negative diagnoses were applied only to the malignant lesions after confirmation by histopathology. In the first group, nine malignant and 28 benign diagnoses were made by FNA; of which three were false-negative. In the second group, there were nine malignant and 46 benign diagnoses with three false negatives. The overall performance of the FNA showed 76% sensitivity and 100% specificity. In conclusion, FNA of the cystic neck lesions offers an invaluable and highly specific initial diagnostic approach for the management of the patients.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

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A correlation study of diagnostic fine‐needle aspiration with histologic diagnosis in cystic neck lesions

Moatamed

Naini

Fathizadeh

et al. 2009

Diagnostic Cytopathology

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Measurement of fine‐needle aspiration thyroglobulin levels increases the detection of metastatic papillary thyroid carcinoma in cystic neck lesions

Holmes

Sokoll

2014

Cancer Cytopathology

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BACKGROUND:Patients with previously resected papillary thyroid carcinoma (PTC) are monitored for disease recurrence/metastasis by ultrasound surveillance and fine-needle aspiration (FNA) cytology. However, accurate diagnosis in lesions with cystic degeneration may be difficult due to scant cellularity. In the current study, the authors evaluated thyroglobulin in FNA (Tg-FNA) for detecting metastatic and/or recurrent PTC in patients with cystic neck lesions after thyroidectomy. METHODS: The pathology records were retrospectively searched for patients with previously resected PTC and subsequent Tg-FNA on a cystic neck mass. Tg-FNA was measured in needle rinses using a Tg assay. The ultrasound findings, Tg-FNA concentrations, and cytological and follow-up histological diagnoses were correlated. RESULTS: A total of 21 FNA specimens of cystic lesions from 19 patients were identified. Of 7 cases with cytologic and subsequent histologic diagnoses of metastatic PTC, the median Tg-FNA level was 100,982 ng/mL. Of 8 cytologically benign cases, 7 cases had Tg-FNA levels < 0.2 ng/mL, and 1 aberrant case demonstrated elevated Tg-FNA of > 1000 ng/mL. For 6 cytologically equivocal cases, including 3 classified as atypical/suspicious for carcinoma, 2 classified as insufficient/acellular debris, and 1 classified as spindle cell neoplasm, 4 patients demonstrated markedly elevated Tg-FNA levels (> 150 ng/mL) with subsequent surgical confirmation of metastatic PTC, whereas 2 patients had Tg-FNA levels of < 0.2 ng/mL with negative follow-up. Using a cutoff value of 0.2 ng/mL, Tg-FNA demonstrated a sensitivity of 100% and specificity of 87.5%. CONCLUSIONS:Tg-FNA is a useful ancillary test that improves the detection of cystic PTC metastases. Particularly in cytologically nondiagnostic cases, the measurement of Tg-FNA helps to distinguish benign from malignant cystic lesions.

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Thyroid FNA biopsies comprised of abundant, mature squamous cells can be reported as benign: A cytologic study of 18 patients with clinical correlation

Chen

Renshaw

Faquin

et al. 2018

Cancer Cytopathology

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Cystic lesions of the head and neck: cytohistological correlation in 63 cases

Abstract: Disparate entities may present with similar cytological findings in the H&N region. A detailed description of differential diagnosis should be given in the cytology report in suspicious cases. Repeated aspirations from different sites of the lesion may reduce the false-negative rate.

Cited by 27 publications

References 16 publications

A correlation study of diagnostic fine‐needle aspiration with histologic diagnosis in cystic neck lesions

A correlation study of diagnostic fine‐needle aspiration with histologic diagnosis in cystic neck lesions

Measurement of fine‐needle aspiration thyroglobulin levels increases the detection of metastatic papillary thyroid carcinoma in cystic neck lesions

Thyroid FNA biopsies comprised of abundant, mature squamous cells can be reported as benign: A cytologic study of 18 patients with clinical correlation

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