Cytochrome CYP2E1 phenotyping and genotyping in the evaluation of health risks from exposure to polluted environments

Lucas, Danièle; Ferrara, Roberta; Gonzales, Eva; Albores, Arnulfo; Manno, Maurizio; Berthou, F.

doi:10.1016/s0378-4274(00)00287-3

Cited by 36 publications

(18 citation statements)

References 34 publications

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“…For chronic hepatitis B virus carriers with high-titer viremia (>10(5) virions/ml) are at increased risk for liver cancer, hepatitis B virus may also impact the function of cytochrome P450 (P450) CYP2E1 enzyme (Harris et al, 2003). What's more, alteration in the level of CYP2E1 might influence the health effects of the environmental pollutants (Lucas et al 2001). Therefore the differences of environment in Asian countries might contribute to the distinction of CYP2E1 impact.…”

Section: Discussionmentioning

confidence: 99%

CYP2E1 RsaI/PstI Polymorphism and Liver Cancer Risk among East Asians: a Huge Review and Meta-analysis

Tian

Li²,

Zhao³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Published data on any association between the CYP2E1 RsaI/PstI (c1/c2) polymorphism and liver cancer risk among east Asians are inconclusive. The aim of this Human Genome Epidemiology (HuGE) review and metaanalysis was to derive a more precise estimation of the relationship. A literature search of Pubmed, Embase, Web of science and CBM databases from inception through July 2012 was conducted. Twelve case-control studies were included with a total of 1,552 liver cancer cases and 1,763 healthy controls. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association under five genetic models. When all the eligible studies were pooled into the meta-analysis, the results showed that the c2 allele and the c2 carrier (c2/c2 + c2/c1) of RsaI/PstI polymorphism were associated with decreased risk of liver cancer among east Asians (

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Section: Discussionmentioning

confidence: 99%

CYP2E1 RsaI/PstI Polymorphism and Liver Cancer Risk among East Asians: a Huge Review and Meta-analysis

Tian

Li²,

Zhao³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Results of epidemiologic studies indicated that exposure to pesticides was associated with increased risk from cancer (Blair and White 1981;Blair et al 1983;Brown et al 1990;Burmeister 1981;Council on Scientific Affairs 1988;Lucas et al 2001;Mills and Zahm 2001). No congenital malformations were reported in the offspring of workers occupationally exposed to pesticides.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence of the carcinogenic effects of certain pesticides in animals and an increase in the risk of developing malignancies in occupationally exposed populations have made necessary studies in exposed workers (Lucas et al 2001;Mills and Zahm 2001). Some demographic characteristics may also be useful in categorizing pesticide exposure (Echols et al 2001), in the same manner as studies such as a detailed questionnaire survey concerning the lifetime use of pesticides by workers (Engel et al 2001).…”

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confidence: 99%

Cytogenetic Monitoring in a Population Occupationally Exposed to Pesticides in Ecuador

Paz‐y‐Miño¹,

Bustamante²,

Sánchez³

et al. 2002

Environ Health Perspect

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“…Because of its wide range of substrates (aromatic and halogenated hydrocarbons, halogenated anaesthetics, alcohols, nitrosamines…), this cytochrome plays an important role in the field of clinical toxicology [23]. Several CYP2E1 genetic polymorphisms are currently detectable applying techniques involving the RsaI, TaqI, DraI and PstI restriction enzymes, but the clinical significance of these polymorphisms remains unclear, partly because no convincing association between CYP2E1 catalytic activities and their genotypes has been demonstrated [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis

Vuilleumier

Rossier

Chiappe

et al. 2006

Eur J Clin Pharmacol

157

105

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Objective: To determine whether pharmacogenetic tests such as N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1) genotyping are useful in identifying patients prone to antituberculosis drug-induced hepatotoxicity in a cosmopolite population. Methods: In a prospective study we genotyped 89 patients treated with isoniazid (INH) for latent tuberculosis. INH-induced hepatitis (INH-H) or elevated liver enzymes including hepatitis (INH-ELE) was diagnosed based on the clinical diagnostic scale (CDS) designed for routine clinical practice. NAT2 genotypes were assessed by fluorescence resonance energy transfer probe after PCR analysis, and CYP2E1 genotypes were determined by PCR with restriction fragment length polymorphism analysis. Results: Twenty-six patients (29%) had INH-ELE, while eight (9%) presented with INH-H leading to INH treatment interruption. We report no significant influence of NAT2 polymorphism, but we did find a significant association between the CYP2E1 *1A/*1A genotype and INH-ELE (OR: 3.4; 95% CI:1.1-12; p=0.02) and a non significant trend for INH-H (OR: 5.9; 95% CI: 0.69-270; p=0.13) compared with other CYP2E1 genotypes. This test for predicting INH-ELE had a positive predictive value (PPV) of 39% (95% CI: 26-54%) and a negative predictive value (NPV) of 84% (95% CI: 69-94%). Conclusion:The genotyping of CYP2E1 polymorphisms may be a useful predictive tool in the common setting of a highly heterogeneous population for predicting isoniazidinduced hepatic toxicity. Larger prospective randomized trials are needed to confirm these results.

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Cytochrome CYP2E1 phenotyping and genotyping in the evaluation of health risks from exposure to polluted environments

Cited by 36 publications

References 34 publications

CYP2E1 RsaI/PstI Polymorphism and Liver Cancer Risk among East Asians: a Huge Review and Meta-analysis

CYP2E1 RsaI/PstI Polymorphism and Liver Cancer Risk among East Asians: a Huge Review and Meta-analysis

Cytogenetic Monitoring in a Population Occupationally Exposed to Pesticides in Ecuador

CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis

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