Cytogenetic analysis of 100 consecutive newly diagnosed cases of acute lymphoblastic leukemia in Rio de Janeiro

Silva, Maria Luiza Macedo; Souza, Maria Helena Ornellas de; Ribeiro, Raul C.; Land, Marcelo Gerardin Poirot; Azevedo, Alexandro Barbosa de; Vasconcelos, Felippe; Otero, Luize; Vasconcelos, Zilton; Bouzas, L.F.; E, Abdelhay

doi:10.1016/s0165-4608(02)00535-6

Cited by 24 publications

(21 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to structural abnormalities, some recurrent translocations such as t(4;11) and t(9;22) were present at similar incidence to that reported in previous studies especially to that found in the Brazilian population by Silva et al [2].…”

Section: Discussionsupporting

confidence: 83%

Cytogenetic analysis of 298 newly diagnosed cases of acute lymphoblastic leukaemia in Tunisia

Gmidène¹,

Sennana²,

Elghezal³

et al. 2008

Hematological Oncology

View full text Add to dashboard Cite

Genetic changes associated with Acute Lymphoblastic Leukaemia (ALL) provide diagnostic and prognostic information with a direct impact on patient management. We report the cytogenetic analysis of 298 Tunisian patients with ALL, including 183 children and 115 adults. Chromosome abnormalities have been detected in 68.2% of our patients associating clonal numerical and/or structural rearrangements. Some chromosomal abnormalities especially hyperdiploidy, 19p13 abnormalities, 8q24 translocations, 12p, 6q deletions and TCR rearrangements occur at a lower incidence compared to that reported in other populations. ALL cases (5.7%) had miscellaneous clonal abnormalities. We also found in our Tunisian series a higher incidence for T-lineage ALL more than usually described. Among structural chromosomal abnormalities, t(9;22)(q34;q11) resulting in the BCR/ABL fusion and the t(12;21)(p13;q22) resulting in the TEL/AML1 fusion were studied by FISH providing additional diagnostic and prognostic information. We conclude that although the incidence of our cytogenetic results are slightly different, their clinical significance is similar to that described in the literature.

show abstract

Section: Discussionsupporting

confidence: 83%

Cytogenetic analysis of 298 newly diagnosed cases of acute lymphoblastic leukaemia in Tunisia

Gmidène¹,

Sennana²,

Elghezal³

et al. 2008

Hematological Oncology

View full text Add to dashboard Cite

show abstract

“…For instance, the karyotype profiles and recurrent abnormalities found in a series of 100 consecutive newly diagnosed cases of ALL in Rio de Janeiro (~50 cases were included in this manuscript), is similar to those described by other European groups. Magalhães et al, reached a conclusion by demonstrating that the frequency, age distribution and clinical features of 20% of TEL/AML1 fusion genes in c-ALL were similar to those found in patients from the US and Europe 18,19 The frequency of "anomalous" markers such as myeloid associated antigens (CD33/CD13) detected in ALL were similar to those described in different group's therapeutic protocols. Although inherited genetic factors cannot be entirely ruled out, our findings favor the suggestion that the immunophenotype characteristics is more related to age at diagnosis and it is likely that these differences in ALL subtypes are real, reflecting socio-economic and life-style factors, rather than the putative race suggested by the appearance of individuals.…”

Section: Discussionmentioning

confidence: 57%

“…Standard cytogenetic and molecular analysis were performed in samples from institutions of Rio de Janeiro and Brasilia their results are described elsewhere. 18,19 Statistical analysis The total data sets were analyzed using the statistical package SPSS 11.0. In order to evaluate the variables frequencies, distributions and comparisons of proportions of cases, an extension of Pearson chi-square test was applied to detect statistically significant differences in demographic characteristics by region for all variables and for ALL subtypes.…”

Section: Leukemia Classificationmentioning

confidence: 99%

Biological diversity variations of pediatric acute leukemia in Brazil: contribution of immunophenotypic profiles to epidemiological studies

Pombo‐de‐Oliveira¹,

Córdoba²,

Alencar³

et al. 2005

Rev. Bras. Hematol. Hemoter.

View full text Add to dashboard Cite

“…According to this finding, Silva et al [16] found a karyotype of a DS patient involving four clones. In the literature, the relative risk of acute leukemia in the first 5 years has been estimated to be 56 times that of non-DS individuals with an equal frequency of acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) [17].…”

Section: Discussionmentioning

confidence: 92%

Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population

Gil

Lajus²,

Moura

et al. 2013

Mol Cytogenet

View full text Add to dashboard Cite

BackgroundCytogenetic studies in Brazilian population about childhood acute lymphoblastic leukemia (ALL), the most common childhood malignancy, are scarce. Moreover, Brazilian race is very heterogeneous and is made by the confluence of people of several different origins, from the original Native Brazilians, with the influx of Portuguese colonizers, Black African slaves, and recent European, Arab and Japanese immigration. The purpose of this prospective, multicentric study was to assess the sociodemographic, clinic and cytogenetic characteristics of the children treated for ALL in the Northeast region of Brazil.ResultsThis study includes thirty patients between 4 months and 17 years old treated for ALL from January 1st, 2009 to November 30th, 2010. Cytogenetic analysis showed that in nineteen out of thirty patients (64%) presented some chromosome abnormalities, in which 53% corresponds to numerical abnormalities, 21% structural and numerical abnormalities, and 26% only structural changes. Moreover, seven patients presented complexes karyotype not yet described in the literature. Taken together these results show the importance of the cytogenetic analysis in ALL pediatric patients and illustrates that the studied population presented unexpected complexes karyotypes which were correlated to poor outcome.ConclusionThe results demonstrate the importance of banding cytogenetics for ALL diagnosis despite the use of most modern techniques such as FISH and aCGH, and provide reliable insight into the ALL in Brazil.

show abstract

Cytogenetic analysis of 100 consecutive newly diagnosed cases of acute lymphoblastic leukemia in Rio de Janeiro

Cited by 24 publications

References 14 publications

Cytogenetic analysis of 298 newly diagnosed cases of acute lymphoblastic leukaemia in Tunisia

Cytogenetic analysis of 298 newly diagnosed cases of acute lymphoblastic leukaemia in Tunisia

Biological diversity variations of pediatric acute leukemia in Brazil: contribution of immunophenotypic profiles to epidemiological studies

Banding cytogenetic analysis in pediatric patients with acute lymphoblastic leukemia (ALL) in a Brazilian population

Contact Info

Product

Resources

About