Cytogenetic consequences of chronic irradiation in rodent populations inhabiting the Eastern Ural Radioactive Trace zone

Yalkovskaya, L. E.; Grigorkina, E. B.; Тарасов, О. В.

doi:10.1134/s0006350911010258

Cited by 8 publications

(4 citation statements)

References 4 publications

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“…There are enough data on genomic instability and transgenerational transmission of radiation-induced genetic instability between generations in human [10] and in mouse-like rodents chronically exposed to low-dose radiation from Chernobyl fallout (22 generations over 10 years) [11]. By the way, our data [12] also testify about intensive mutagenic process in S. uralensis and field mice (Apodemus agrarius) from the EURT zone and significant positive correlation of the frequency of aberrant cells in bone marrow and the specific activity of the 90 Sr in the bone tissue.…”

Section: Role Of Overwinteredmentioning

confidence: 72%

“…Intensification of the mutation process is related to the elevated content of 90 Sr in the environment and its significant accumulation in the animals' bone tissue. According to our data [12], in spite of the significant variability of individual specific activities of 90 Sr and cytogenetic parameters, an excess over background values of radionuclide accumulation by eight or more times leads to a significant increase in chromosomal instability at the population level. However, the possibility of radioadaptation in a series of generations that developed due to ecophysiological features (subterranean borrowing way of life, quite low migratory activity) and isolation of settlement in the EURT zone (since 1957) was shown in mole-voles (Ellobius talpinus) [13,14].…”

Section: Accumulation Of 90 Srmentioning

confidence: 99%

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East urals radioactive trace: Adaptive strategy of rodents’ population

Grigorkina

Olenev

2011

Radioprotection

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Abstract. Population of small rodents in radiocontaminated environment is compelled to include more energy-intensive way of maintenance its ability to live -increasing of the proportion of mature young of the year (first pathway of ontogeny). Their reproductive characteristics -actual fecundity was higher, whereas embryonic mortality and the proportion of females with embryonic losses were significantly lower compared with neighboring areas. Abundance of mice in the impact zone was higher, age cross was revealed, which improves the adaptive possibility of the population. Preconditions for acceleration of evolutionary transformations of a population are created, but this process is restrained by both the local configuration of the polluted territory and migration of murine rodents. As a consequence, the population decreases the probability that certain changes will be fixed and inherited in a series of generations. Chronic low-dose radiation (stress) can be considered as the mechanism of switching of life history of cyclomorphic mammals. Thus, ontogenetic multiversality of small mammals is an important mechanism of protection strategy of population and decreasing the damaging action on biota in radiocontaminated environment. Functional approach makes it possible to reduce errors in assessing the radiological consequences and hence, can provide a reliable methodological basis for organization of biological monitoring.

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Section: Role Of Overwinteredmentioning

confidence: 72%

Section: Accumulation Of 90 Srmentioning

confidence: 99%

East urals radioactive trace: Adaptive strategy of rodents’ population

Grigorkina

Olenev

2011

Radioprotection

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“…Consequently, the level of radiation exposure within the EURT area is not sufficient to change the evolutionary formed features of these species. Genetic markers of inherited changes in the body (microsatellite and allozyme variations) indicate that there is no difference in haplotype of irradiated and control animals (Makova et al, 2000;Modorov & Pozolotina, 2011), despite the fact that chromosomal abnormalities demonstrate the reaction of the genome of some cells on chronic radiation (Yalkovskaya et al, 2010). The ontogenetic determination of changes in the small mammals within the radioactive areas was substantiated in numerous works (Vasilev & Vasileva, 2000;Vasil´ev, 2005;Lyubashevskiy et al, An alternative mechanism to protect a body from damaging effects, including radiation, is the hypobiosis or the strategy of tolerance (Kulinskii & Ol´khovskii, 1992).…”

Section: Multivariate Comparison Of Rodents Samplesmentioning

confidence: 99%

Biochemical analysis of the metabolism of small rodents living in different radioecological conditions

Orekhova¹,

Rasina²

2012

Rus.J.Theriol.

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“…Estimates of doses and effects of irradiation on plants are presented in [3,4]. Among other animals, the murine rodents are the most studied [5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Assessment of radiation exposure of murine rodents at the EURT territories

et al. 2014

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The study provides data on contemporary levels of radiation exposure of organs and tissues of murine rodents (several species of mice and voles) inhabiting the East-Ural Radioactive Trace. The estimation procedure involves the most advanced approach based on application of appropriate voxel phantom and biokinetic model. Input data for dose assessment are the results of measurements of skeletal 90Sr activity concentration. Maximal internal dose to skeleton, accumulated during 45 days, is 303 mGy. Median internal dose rates on the last day before trapping were 0.83, 0.092 and 0.023 mGy/day for animals trapped at the sites with initial (1957) 90Sr surface contamination >37 MBq/m2, 18.5–37 MBq/m2 and 0.074–18.5 MBq/m2 respectively. Taking to account internal and external exposures, upper boundary of the ICRP Derived Consideration Reference Level (DCRL) is exceeded on the territory with maximal level of the initial 90Sr surface contamination. On the territory with 18.5–37 MBq/m2, whole body mean dose rates to murine rodents exceed the lower boundary of DCRL. On the areas with lower level of surface contamination, even the 90-th percentile of dose rate is below the DCRL.

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Cytogenetic consequences of chronic irradiation in rodent populations inhabiting the Eastern Ural Radioactive Trace zone

Cited by 8 publications

References 4 publications

East urals radioactive trace: Adaptive strategy of rodents’ population

East urals radioactive trace: Adaptive strategy of rodents’ population

Biochemical analysis of the metabolism of small rodents living in different radioecological conditions

Assessment of radiation exposure of murine rodents at the EURT territories

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