Cytogenetic Effect of Some Insecticides in Mouse Spleen

Amer, Soheir M.; Fahmy, Maha A.; Donya, Souria M.

doi:10.1002/(sici)1099-1263(199601)16:1<1::aid-jat294>3.0.co;2-a

Cited by 29 publications

(5 citation statements)

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“…23 Many other organophosphorus insecticides have been reported to cause chromosomal aberrations in mammalian cells. 15,18,[24][25][26][27][28] With respect to the other insecticides, buprofezin and Super Royal, the present results indicate that in addition to their low mammalian toxicity they had a weak clastogenic effect in somatic…”

Section: Resultsmentioning

confidence: 81%

Genotoxicity evaluation of buprofezin, petroleum oil and profenofos in somatic and germ cells of male mice

Fahmy

Abdalla

1998

J. Appl. Toxicol.

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The two pest control agents, buprofezin and petroleum oil (Super Royal), were tested to evaluate their potential mutagenicity, in comparison with the organophosphorus insecticide profenofos. Chromosomal aberration analysis was used in both somatic and germ cells of male mice. Single oral treatment at three different dose levels (1/16, 1/8 and 1/4 LD 50) for each insecticide induced an increase in the percentage of chromosomal aberrations in bone‐marrow cells 24 h post‐treatment, indicating a dose‐dependent relationship. The percentage of chromosomal aberrations reached 23 ± 0.73, 10.5 ± 0.64 and 15 ± 1.4 after treatment with the highest tested dose of profenofos, buprofezin and Super Royal, respectively. Such percentages did not exceed the corresponding value of the positive control, mitomycin C (29.2 ± 0.69). The percentage of chromosomal aberrations induced by the different doses of profenofos was still highly significant even after excluding gaps. The same trend of results was noticed only at the highest tested dose of buprofezin and Super Royal. With respect to germ cells, profenofos is also a potent inducer of chromosomal aberrations in 1ry spermatocytes, giving percentages of 14 ± 1.3 and 19 ± 1.6 at the two higher doses of 4.25 and 8.5 mg kg−1 body wt., respectively. Buprofezin and Super Royal had no significant effect on mouse spermatocytes at the tested concentrations. The various types of induced aberrations were examined and recorded in both somatic and germ cells. In conclusion, the present investigation indicates that the two pest control agents buprofezin and Super Royal are relatively much safer compounds than the conventional organophosphorus insecticides. © 1998 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 81%

Genotoxicity evaluation of buprofezin, petroleum oil and profenofos in somatic and germ cells of male mice

Fahmy

Abdalla

1998

J. Appl. Toxicol.

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“…CPF cytogenetic toxicity has been detailed in previous studies both in vitro and in vivo. Amer et al (1996) reported CPF induced chromosome aberrations in mouse spleen cell cultures and increased MN cells in rat bone marrow when treated with CPF (Muto et al, 1992). However, the information on the effect of multiple lower doses and its relationship with gender is missing or very less.…”

Section: Discussionmentioning

confidence: 99%

Genotoxicity evaluation of chlorpyrifos: a gender related approach in regular toxicity testing

et al. 2013

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-The oral intubation of chlorpyrifos, an extensively used organophosphate insecticide, was tested for its capability to induce in vivo genotoxic upshot in blood lymphocytes of 24 male and female Wistar rats using biomarker of genotoxicity. Rats were orally administered with daily doses 3 and 12 mg/kg body weight (BW) of chlorpyrifos (CPF). The blood lymphocytes were harvested after 7 and 14 days of treatment and subjected to bi-nucleus (BN), multi-nucleus (MN) and single cell gel electrophoresis (comet assay) to evaluate the extent of DNA damage. Other than BN and MN assay, damage to DNA was assessed through comet length, height, area, head diameter, head DNA percentage and tail DNA percentage along with tail movement. A significant boost was noticed in the frequency of BN cells formation after 12 mg/kg BW CPF treatment. However, the propensity to produce MN cells was significantly more (P ≤ 0.05) in males than that of females. Likewise, the frequency of comet formation, mean comet length, height and area were more (P ≤ 0.05) in males than females even with 12 mg/kgBW. Comet head DNA % and tail length remained non-significant. Olive movement also revealed a significant increase (P ≤ 0.05) in males than females. The study inferred that the CPF can induce DNA damage in both male and female subjects but more pronounced in the male individuals.

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“…Some in vivo studies have provided more data related to the genotoxicity of DDT throughout the years. For instance, a study done in mice indicated that after 24 h of DDT injection the chromosomal aberrations reached its maximum percentage (102). Thereafter, it was described that DNA damage was among the effects caused by DDT and its metabolites, which was demonstrated in both, in vitro and in vivo studies including human and non-human test systems (88).…”

Section: Dichlorodiphenyltrichloroethane (Ddt)mentioning

confidence: 99%

Endocrine disruptors from the environment affecting breast cancer (Review)

et al. 2020

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Evaluation of carcinogenic substances from the environment is a challenge for scientists. Recently, a novel approach based on 10 key characteristics of human carcinogens classified by the International Agency for Research on Cancer (IARC) has emerged. Carcinogenesis depends on different mechanisms and factors, including genetic, infectious (bacteria, viruses) and environmental (chemicals) factors. Endocrine disruptors are exogenous chemicals that can interfere and impair the function of the endocrine system due to their interaction with estrogen receptors or their estrogen signaling pathways inducing adverse effects in the normal mammary development, originating cancer. They are heterogeneous chemicals and include numerous synthetic substances used worldwide in agriculture, industry and consumer products. The most common are plasticizers, such as bisphenol A (BPA), pesticides, such as dichlorodiphenyltrichloroethane, and polychlorinated biphenyls (PCBs). Xenoestrogens appear to serve an important role in the increased incidence of breast cancer in the United States and numerous other countries. Several studies have demonstrated the role of organochlorine xenoestrogens in breast cancer. Therefore, the overall cumulative exposure of women to estrogens results in an increased risk for this type of cancer. Factors like lifestyle and diet also serve a role in the increased incidence of this disease. The aim of the present study was to analyze these chemical compounds based on the key characteristics given by the IARC, with a special focus on breast cancer, to establish whether these compounds are carcinogens, and to create a model for future analysis of other endocrine disruptors.

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Cytogenetic Effect of Some Insecticides in Mouse Spleen

Cited by 29 publications

References 0 publications

Genotoxicity evaluation of buprofezin, petroleum oil and profenofos in somatic and germ cells of male mice

Genotoxicity evaluation of buprofezin, petroleum oil and profenofos in somatic and germ cells of male mice

Genotoxicity evaluation of chlorpyrifos: a gender related approach in regular toxicity testing

Endocrine disruptors from the environment affecting breast cancer (Review)

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