Cytogenetic Effects of Cyclamates on Human Cells in vitro

Abstract

Chromosome studies on human cells in vitro have shown that the artificial sweeteners, sodium and calcium cyclamate, can induce chromosome breaks in vitro in human cells, in both leukocyte and monolayer cultures.

Cytogenetic Studies in Rats of Cyclohexylamine, a Metabolite of Cyclamate

“…Stone et al have reported on the effect of cyclamate in leukocyte cultures in vitro (6), and Sax and Sax have reported on the effect of cyclamates in plant cells (7). The present study demonstrates the effect of a metabolite of cyclamate, cyclohexylamine, in both somatic and spermatogonial cells of rats.…”

“…Five to 15 and 600 to 1000 unit/ml of circulating interferon were detected 6 isoamylalcohol. The polymers were isolated by chromatography on Sephadex G25 and, finally, Sephadex G100.…”

The effect of cyclamate and saccharin on the chromosomes of a Chinese hamster cell line

“…Sodium and calcium cyclamate were tested on human chromosomes, both in normal cells and in cancer cells in culture, by STONE et al (1969). They obtained convincing evidence of a low but consistent increase in chromosome aberrations.…”

Beitrag zur hygienischen Beurteilung von Cyclamat

“…Was die Umwandlung von Cyclamat im Organismus anlangt, wurde in Japan, in GroBbritannien und in den USA festgestellt [12][13][14] …”