Cytogenetic effects on the eastern mudminnow, Umbra pygmaea, exposed to ethyl methanesulfonate, benzo[a]pyrene, and river water

Hooftman, R.N.; Vink, G.J.

doi:10.1016/0147-6513(81)90001-4

Cited by 68 publications

(13 citation statements)

References 13 publications

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“…2 and 3) indicates that PAHs are stronger EROD inducers than RAs. Results concerning NA induction by BP confirmed its mutagenic potential observed in previous studies, where an erythrocytic micronuclei induction in Pleurodeles waltl (Urodela) (Grinfeld et al, 1986), chromosome aberrations in Nothobranchius rachovi (Hooftman and Vink, 1981) and Umbra pygmaea (Hooftman, 1981), and hepatocarcinogenicity in O. mykiss (Hendricks et al, 1985) were detected. Furthermore, BP presents five benzene rings and, according to IARC data (1983), PAHs with four or more condensed benzene rings are often mutagenic and/or carcinogenic.…”

supporting

confidence: 91%

Induction of EROD Activity and Genotoxic Effects by Polycyclic Aromatic Hydrocarbons and Resin Acids on the Juvenile Eel (Anguilla anguillaL.)

Pacheco

Santos

1997

Ecotoxicology and Environmental Safety

108

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supporting

confidence: 91%

Induction of EROD Activity and Genotoxic Effects by Polycyclic Aromatic Hydrocarbons and Resin Acids on the Juvenile Eel (Anguilla anguillaL.)

Pacheco

Santos

1997

Ecotoxicology and Environmental Safety

108

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“…Notwithstanding the fact that in fish, lower MN frequencies, both spontaneous and induced, can be observed with respect to mammals (Rizzoni et al, 1987), a dose-dependent and time-dependent response has been ascertained by many authors (Hooftman and Vink, 1981;Hose et al, 1984;Das and Nanda, 1986). This confirms the suitability of this test system to study the relationship between pollution levels and mutagenic toxicity.…”

Section: Discussionsupporting

confidence: 58%

Micronucleus test in erythrocytes of Barbus plebejus (Teleostei, Pisces) from two natural environments: a bioassay for the in situ detection of mutagens in freshwater

Minissi

Ciccotti

Rizzoni

1996

Mutation Research/Genetic Toxicology

132

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Erythrocyte micronucleus frequencies in wild fish from two riverine environments and in fish reproduced and reared under controlled conditions (control group) were compared, with the aim to evaluate the suitability of the MN test for the in situ detection of mutagens in freshwaters. Fish were caught in different months in two rivers of central Italy which have different pollution levels. As indicator species, the barbel (Barbus plebejus) was chosen because of its ecological significance. Blood samplings were performed on wild fish immediately after capture and repeated at different time intervals on the same individuals, which were maintained in controlled conditions after capture. A total of 10000 erythrocytes per specimen were scored. No significant differences in micronucleus frequencies were observed between the control group and fish from the unpolluted river (Mignone). A significantly higher frequency of micronuclei was observed in fish caught in the polluted river (Tiber), in comparison to both the controls and the Mignone river fish. No significant seasonal differences were observed. Barbels examined 50 and 100 days after capture presented a remarkable decrease in micronucleus frequency in comparison with the frequency observed in barbels at capture. The micronucleus test in fish erythrocytes was shown to be a sensitive bioassay for detecting mutagenic pollution in fresh water environments.

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“…A dose-dependent and time-dependent response to MN inducing agents has been ascertained by other authors [11,24,25]. As a speculative observation on the time course of MN induction, according data taken together seem to suggest a rather long cell cycle of the stem cells of this tissue, (see below).…”

Section: X-ray Experimentsmentioning

confidence: 70%

Micronuclei induced in erythrocytes of Cyprinus carpio (teleostei, pisces) by X-rays and colchicine

Gustavino

Scornajenghi

Minissi

et al. 2001

Mutation Research/Genetic Toxicology and Environmental Mutagene

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In the present work the induction of micronuclei in erythrocytes of Cyprinus carpio treated with X-rays and colchicine is studied for the evaluation of mutagenic effects of both clastogenic and mitoclastic (spindle poisoning) agents in this system.Three different experiments were performed treating groups of laboratory-reproduced animals with (1) single doses of X-rays (0.1, 0.5 and 2 Gy); (2) a single i.p. injection of colchicine at the concentrations: 1.6 × 10 −2 , 8× 10 −2 , 0.4 and 2 mg/kg b.w. so as to mimic an acute exposure to the agent and (3) six repeated i.p. injections of the first three concentrations of colchicine, over a period of 18 days, so as to mimic a chronic exposure. Repeated blood samplings were performed by cardiac puncture over a period of about 2 months after the treatment and micronucleus frequencies were determined at multiple times on the same individuals after mutagen exposure. A dose-dependent increase in the micronucleus frequency was observed in irradiated fish and a peak value detected at 21 days. Slight increases of micronucleus frequencies were also observed in both colchicine experiments only for the highest concentrations at the earliest sampling time. Higher concentrations of colchicine clearly showed a lethal effect. According to the present data the micronucleus frequency induced by the highest colchicine dose is comparable to that observed after 0.1 Gy of X-ray irradiation.

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Cytogenetic effects on the eastern mudminnow, Umbra pygmaea, exposed to ethyl methanesulfonate, benzo[a]pyrene, and river water

Cited by 68 publications

References 13 publications

Induction of EROD Activity and Genotoxic Effects by Polycyclic Aromatic Hydrocarbons and Resin Acids on the Juvenile Eel (Anguilla anguillaL.)

Induction of EROD Activity and Genotoxic Effects by Polycyclic Aromatic Hydrocarbons and Resin Acids on the Juvenile Eel (Anguilla anguillaL.)

Micronucleus test in erythrocytes of Barbus plebejus (Teleostei, Pisces) from two natural environments: a bioassay for the in situ detection of mutagens in freshwater

Micronuclei induced in erythrocytes of Cyprinus carpio (teleostei, pisces) by X-rays and colchicine

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