Cytogenetic studies on gas station attendants

Santos-Mello, Renato; Cavalcante, Berenice

doi:10.1016/0165-1218(92)90059-9

Cited by 41 publications

(17 citation statements)

References 25 publications

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“…Brandt et al 22) have demonstrated genotoxic effects in workers exposed to low levels of benzene from gasoline. Santos-Mello et al 12) have shown chromosomal deletions in lymphocytes of workers exposed to gasoline as attendants and also reported hematopoietic malignancy in petrol exposed workers. Similar exposures to gasoline garage mechanics and filling stations have been reported 23) .…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological studies of filling station attendees have shown genotoxic effects at very low benzene from gasoline vapor exposure 12,[19][20][21] . Brandt et al 22) have demonstrated genotoxic effects in workers exposed to low levels of benzene from gasoline.…”

Section: Discussionmentioning

confidence: 99%

“…Petrol evaporates more readily in tropical than in temperate countries 12) . In South India petrol stations are located on streets and workers at the station, have a higher opportunity for exposure.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Genotoxicity in Petrol Station Workers in South India Using Micronucleus Assay

et al. 2010

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In this study, the micronucleus (MN) frequency was assessed as a measure of genotoxicity in exfoliated cells of buccal mucosa extracted from 110 petrol pump workers and 100 controls. For each individual, 3,000 exfoliated buccal cells were analyzed. The individuals used in the study were grouped based on their smoking, drinking alcoholic beverages, and tobacco chewing habits. There was a significantly higher frequency of micronucleated cells in the exposed workers to petrol than in the unexposed control population. Smoking and drinking (alcohol) habits, age and length of occupation represent significant factors in terms of increasing the MN frequency measured in the exposed population. This study demonstrates that, using MN assay, it is possible to assess the cytogenetic damage in exposed individuals and that the significant increase in the induction of the MN in the exposed population suggests that the studied individuals may be at a higher risk of developing cancer and therefore monitored for any long term adverse effects of the exposure.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Evaluation of Genotoxicity in Petrol Station Workers in South India Using Micronucleus Assay

et al. 2010

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“…Increased numerical CA were found in subjects working with auto paints, which used to contain benzene and other organic solvents (Silva and Santos-Mello, 1996). Structural CA, mostly in the form of dicentrics and breaks, were increased in exposed subjects in a majority of studies (Betancourt et al, 1995;Lalchev et al, 1997;Santos-Mello and Cavalcante, 1992;Silva and Santos-Mello, 1996). SCEs were increased in the higher but not the lower exposure group in one preliminary study of workers exposed to organic solvents (Lalchev et al, 1997).…”

Section: Representative Studies In Workers Exposed To Petroleum Fumentioning

confidence: 99%

“…Furthermore, individuals in these studies were subjected to a combination of chemical exposures. For these reasons, these studies are presented together in Table 7 (Betancourt et al, 1995;Carere et al, 1998b;Lalchev et al, 1997;Santos-Mello and Cavalcante, 1992;Silva and Santos-Mello, 1996;Bukvic et al 1998). Increased numerical CA were found in subjects working with auto paints, which used to contain benzene and other organic solvents (Silva and Santos-Mello, 1996).…”

Section: Representative Studies In Workers Exposed To Petroleum Fumentioning

confidence: 99%