Cytokine profile and supposed contribution to scarring in cicatricial pemphigoid

Abstract

Our results highlight the presence of a mixed cytokine pattern in the cellular infiltrate of both blistering diseases, with a corresponding increase of Th2-like activity in fully developed lesions, irrespective of the different sites involved. In addition, the constant presence of TGF-beta1 mRNA in the different lesional phases of CP, and its overlapping expression in BP suggest that the involvement of additional factors is responsible for the scarring course typical of CP.

Salivary IgA and IgG antibodies to bullous pemphigoid 180 noncollagenous domain 16a as diagnostic biomarkers in mucous membrane pemphigoid

“…laminin 332 and α6β4) and a higher proportion of patients with IgG and or IgA antibody isotypes in MMP than in BP . Furthermore, the cytokine profile in MMP may play a role in the scarring capacity of the disease …”

Bullous pemphigoid associated with dipeptidyl peptidase IV inhibitors. A case report and review of literature.

“…11 TGF beta 1 has previously been demonstrated to be elevated in bullous pemphigoid in the serum and not the blister fluid 16,19 ; it's role in the serum has been postulated as a part of the Th3 regulatory component of the autoimmune reaction that inhibits further production of inflammatory cytokines like interferon gamma and interleukin 2. [15][16][17] The DPP-IV receptor, on the other hand, is felt to play an important role in the Th1 component of immunity. 13 Bullous pemphigoid has previously demonstrated a combination of Th1, Th2, and Th3 mediated immunity through the measurement of its various cytokines.…”

IL-4 and cellular adhesion molecule (CAM) pathway are involved in cicatricial pemphigoid scarring process

“…In previous studies [6,7], our group has investigated by both immunohistochemistry and in situ hybridization the expression of Th1, Th2 and Th3 cytokines at protein and mRNA level in CP and BP biopsies. The strong expression of TGF-b 1 detected in both bullous diseases pointed out this pleiotropic cytokine could be more involved in immunoregulation and tolerance [8] rather than in fibrogenesis.…”