Cytologic findings in granular cell tumors, with emphasis on the diagnosis of malignant granular cell tumor by fine-needle aspiration biopsy

Cytologic features of angioleiomyoma: Cytologic‐histologic study of 10 cases

“…These characteristics are not sufficiently characteristic to permit a histotype diagnosis, but together with typical clinical data (painful or tender nodule) may help to exclude other skin or subcutaneous lesions. 18 Presents often in the skin or subcutaneous tissue or in the tongue in adults. May occur at any age and in any location.…”

“…Aspirates from granular cell tumor, however, are usually cellular, lack a collagen matrix, and frequently contain naked nuclei and abundant granular material in the background of the smears. 18 Fibrous histiocytoma comprising the spectrum of cutaneous or subcutaneous dermatofibroma, sclerosing hemangioma, and cellular dermatofibroma is another lesion which may be confused with ALM. Smears from fibrous histiocytoma contain benign spindle cells with an admixture of histiocytes and often some giant cells.…”

Intramuscular Granular Cell Tumor in the Lower Extremities

“…However, these factors only indicate the tumors have a high potential for aggressiveness and are not sufficient to diagnose malignancy. Therefore, there are overlapping features between the benign and malignant tumors in these indicators [10,12]. To diagnose malignant granular cell tumors, careful consideration of the histologic features and the clinical information is needed.…”

Malignant granular cell tumor of the esophagus

“…They classified the granular cell tumors that satisfy three or more of these criteria as histologically malignant granular cell tumors. More recently, Wieczorek et al proposed cytological features of malignant granular cell tumor of the soft part, including hyperchromasia, coarse chromatin, increased N/C ratio, nuclear pleomorphism and vesicular nuclei with enlarged nucleoli and spindle cell morphology, which were associated the most closely with malignancy when they were present throughout the cytological sample [8]. They also reported that mitoses were present in malignant granular cell tumors and absent from all benign granular cell tumors [5].…”