Cytological And Histochemical Studies On Rat Liver And Pancreas During Progression Of Streptozotocin Induced Diabetes And Possible Protection Using Certain Natural Antioxidants

Waer, Hanaa F.; Helmy, Seham A.

doi:10.21608/ejhm.2012.16248

Cited by 6 publications

(1 citation statement)

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“…After a fasting period of at least 8 h, DM was induced in male rats by the intraperitoneal injection of a single dose of alloxan monohydrate (150 mg/kg body weight), which was dissolved in normal saline 22 . Blood glucose levels were measured using a glucometer 48 h after alloxan injection, and rats with fasting blood glucose levels above 250 mg/dl were classified as diabetic 23 .…”

Section: Methodsmentioning

confidence: 99%

Arabic gum ameliorates systemic modulation in Alloxan monohydrate-induced diabetic rats

Ibrahim

Abdelhafez

El-Shamy

et al. 2023

Sci Rep

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Medicinal plants are considered an alternative therapy for diabetes mellitus as they regulate glucose levels. Moreover, a variety of plants offer a rich source of bioactive compounds that have potent pharmacological effects without any negative side effects. The present study aimed to clarify the effects of Arabic gum/Gum Acacia (GA) on the biochemical, histopathological, and immunohistochemical changes observed in diabetic rats. Further, the anti-inflammatory activity of GA in response to diabetes, through inflammatory mediators analysis. Male rats were divided into four groups: untreated control, diabetic, Arabic gum-treated, and Arabic gum-treated diabetic rats. Diabetes was induced using alloxan. Animals were sacrificed after 7 and 21 days of treatment with Arabic gum. Body weight, blood and pancreas tissue samples were collected for analysis. Alloxan injection significantly decreased body weight, increased glucose levels, decreased insulin levels, and caused depletion of islets of Langerhans and β-cell damage in the pancreas. Arabic gum treatment of diabetic rats significantly increased body weight, decreased serum glucose levels, increased insulin levels, exerts anti-inflammatory effect, and improved the pancreas tissue structure. Arabic gum has beneficial pharmacological effects in diabetic rats; therefore, it might be employed as diabetic therapy to reduce the hyperglycemic damage and may be applicable for many autoimmune and inflammatory diseases treatment. Further, the new bioactive substances, such as medications made from plants, have larger safety margins, and can be used for a longer period of time.

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Section: Methodsmentioning

confidence: 99%