Spirulina platensis prevents hyperglycemia in rats by modulating gluconeogenesis and apoptosis via modification of oxidative stress and MAPK-pathways

Sadek, Kadry M.; Lebda, Mohamed A.; Nasr, Sherif; Shoukry, Moustafa

doi:10.1016/j.biopha.2017.06.023

Cited by 69 publications

(55 citation statements)

References 50 publications

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“…The normal range of glucose level must be less than 140 mg/dl. GLB was able to bring back increased glucose level to near normal range which is similar to several studies (Erejuwa et al 2011a;Devi et al 2012), whereas Spirulina fusiformis-treated group was able to control the level in normal range (Sadek et al 2017). The partial destruction of the beta cells by streptozotocin had led to increase in blood glucose levels which were brought to near normal levels by Spirulina administration.…”

Section: Blood Glucose Levelssupporting

confidence: 87%

“…Antidiabetic activity is one of the main medicinal properties of these herbal plants (Zheng et al 2011). Spirulina fusiformis is a Cyanobacterium which has been used as a protein-rich food supplement with ethno pharmacological significance in both humans and animals (Sadek et al 2017). This blue-green alga grows in a warm climate and is a rich source of minerals, vitamins and antioxidant pigments (Sabina et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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Evidence of antidiabetic activity of Spirulina fusiformis against streptozotocin-induced diabetic Wistar albino rats

et al. 2018

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The aim of our study is to investigate the protective effect of against streptozotocin-induced diabetes inWistar albino rats. Rats were divided into five groups: group I was normal control, group II was diabetic control (50 mg/kg b.w. of streptozotocin, i.p.), group III was (400 mg/kg b.w., p.o.) treated diabetic rats; group IV was Glibenclamide (0. 6 mg/kg b.w., p.o.) treated diabetic rats and group V was treated with (400 mg/kg b.w., p.o.) alone. There was significant elevation in the levels of blood glucose, serum lipid profile and serum renal markers (total protein, urea, creatinine and uric acid) in the diabetic rats. Also, diabetic rats showed significantly ( < 0.05) reduced antioxidant status (reduced levels of superoxide dismutase, catalase, glutathione peroxidase, glutathione--transferase and reduced glutathione; increased levels of TBARS), impaired oral glucose tolerance and elevated HbA1C. was able to normalize the above mentioned parameters. Significant histopathological changes were found in the pancreas, liver and kidney sections of the diabetic control group while treatment with was able to minimize the extent of tissue damage. Current study shows that possesses significant antidiabetic and antihyperlipidemic effects in streptozotocin-induced diabetic rats by effectively reducing the rise in blood glucose levels and lipid profile.

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Section: Blood Glucose Levelssupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Evidence of antidiabetic activity of Spirulina fusiformis against streptozotocin-induced diabetic Wistar albino rats

et al. 2018

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“…The mechanism of STZ action on pancreatic β-cells has not yet been fully understood; however, it is believed that oxidative stress plays an important role in the development of the STZ-induced complications (Sadek et al. 2017). STZ is an unstable molecule that accumulates in the pancreatic β-cells and degrades to carbonium radicals.…”

Section: Discussionmentioning

confidence: 99%

“…ROS, such as hydroxyl and superoxide radicals attack important cellular macromolecules, such as carbohydrates, nucleic acids, lipids and protein leading to cell damage and death (Sadek et al. 2017).…”

Section: Introductionmentioning

confidence: 99%

The protective effect of Satureja bachtiarica hydroalcoholic extract on streptozotocin‐induced diabetes through modulating glucose transporter 2 and 4 expression and inhibiting oxidative stress

Joudaki

Setorki

2019

Pharmaceutical Biology

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Context: Oxidative stress plays an important role in development of diabetes mellitus. Satureja bachtiarica Bunge (Lamiaceae) is a rich source of bioactive compounds with antioxidant properties. Objective: This study investigates the antidiabetic effect of hydroalcoholic extract of aerial parts of S. bachtiarica . Methods and materials: Male Wistar rats were randomly divided into six groups ( n = 8) including control (normal saline), diabetic [Streptozotocin (STZ)], intervention (STZ plus hydroalcoholic extract of S. bachtiarica at doses of 75, 150 and 250 mg/kg/d) and positive control (STZ plus captopril 50 mg/kg/d) groups. A single intraperitoneal (IP) injection of STZ (60 mg/kg) was used to induce diabetes and IP therapy with drugs was performed for four weeks. Results : In diabetic rats, serum total antioxidant capacity (TAC) decreased significantly, but glucose, alkaline phosphatase ( ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT) and malondialdehyde (MDA) increased significantly as compared to the control ( p < 0.05). Treatment with extract (250 mg/kg) caused a significant decline in serum glucose, GGT, ALT, AST and MDA as well as a significant increase in serum TAC ( p < 0.05). During the intervention period, diabetic rats showed significant weight loss, but extract (250 mg/kg) treated rats did not show any weight loss. Extract (250 mg/kg) up-regulated GLUT2 expression and down-regulated GLUT4 expression in the liver ( p < 0.05). S . bachtiarica extract at all dosage levels prevented STZ-induced histological damage of liver, kidney and pancreas. Discussion and conclusions: S . bachtiarica extract exhibits antidiabetic effects through modulation of oxidative stress and expression of GLUT2 and GLUT4 .

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“…In addition, Neyrinck et al showed that the oral administration of a Spirulina is able to modulate the gut microbiota and to activate the immune system in the gut, which is a mechanism that may be involved in the improvement of the hepatic inflammation in aged mice [5]. Meanwhile, numerous studies showed that Spirulina and Spirulina -derived peptides possess multiple activities such as prevention of hyperglycemia [6], antioxidant, immunomodulatory, and anti-inflammatory effects after dietary supplementation [7]. Furthermore, Souza and his research group payed much attention to the benefits of the topical application of Spirulina .…”

Section: Introductionmentioning

confidence: 99%

N-Terminal Acetylation and C-Terminal Amidation of Spirulina platensis-Derived Hexapeptide: Anti-Photoaging Activity and Proteomic Analysis

et al. 2019

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Ultraviolet (UV) irradiation is a potent inducer for skin photoaging. This paper investigated the anti-photoaging effects of the acetylated and amidated hexapeptide (AAH), originally identified from Spirulina platensis, in (Ultraviolet B) UVB-irradiated Human immortalized keratinocytes (Hacats) and mice. The results demonstrated that AAH had much lower toxicity on Hacats than the positive matrixyl (81.52% vs. 5.32%). Moreover, AAH reduced MDA content by 49%; increased SOD, CAT, and GSH-Px activities by 103%, 49%, and 116%, respectively; decreased MMP-1 and MMP-3 expressions by 27% and 29%, respectively, compared to UVB-irradiated mice. Employing isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics, 60 differential proteins were identified, and major metabolic pathways were determined. Network analysis indicated that these differential proteins were mapped into an interaction network composed of two core sub-networks. Collectively, AAH is protective against UVB-induced skin photoaging and has potential application in skin care cosmetics.

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Spirulina platensis prevents hyperglycemia in rats by modulating gluconeogenesis and apoptosis via modification of oxidative stress and MAPK-pathways

Cited by 69 publications

References 50 publications

Evidence of antidiabetic activity of Spirulina fusiformis against streptozotocin-induced diabetic Wistar albino rats

Evidence of antidiabetic activity of Spirulina fusiformis against streptozotocin-induced diabetic Wistar albino rats

The protective effect of Satureja bachtiarica hydroalcoholic extract on streptozotocin‐induced diabetes through modulating glucose transporter 2 and 4 expression and inhibiting oxidative stress

N-Terminal Acetylation and C-Terminal Amidation of Spirulina platensis-Derived Hexapeptide: Anti-Photoaging Activity and Proteomic Analysis

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