Cytological evaluation of benign breast lesions with histopathological correlation

Velu, Ambedkar Raj Kulandai; Srinivasamurthy, Banushree C; Rani, J. Sandhya

doi:10.5958/2394-6792.2016.00002.8

Cited by 8 publications

(6 citation statements)

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“…According toNandan Kumar et al 7 the sensitivity and specificity of breast ultrasound in categorising breast lesions as benign and malignant was 85.4% and 89.31%, which is slightly lesser compared to our study. Studies done byPuja B. Jarwani et al 8 and Ambedkar Raj, KulandaiVelu et al 9 , showed that breast FNAC had a sensitivity ranging from 82% to 97.5% and specificity of more than 99%, which is comparable to our study. Study done by Shanmugasamy K et al 10 showed that the sensitivity, specificity and diagnostic accuracy of breast FNAC in diagnosis of malignancy was 93.5%,100%and 98.3% respectively.…”

Section: Discussionsupporting

confidence: 90%

Radiological and Cytological Correlation of Breast Lesions with Histopathological Findings in a Tertiary Care Hospital in Costal Karnataka

Richie¹,

Mellonie²

2019

IJCMR

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Introduction: Breast cancer is the leading cause of cancer deaths among women worldwide. Breast cancer clinically presents as breast lump.Fine needle aspiration cytology (FNAC) and breast ultrasound (sonomammography) is pivotal in characterization of a breast lump as benign and malignant lesion. There is a need to study radiological and cytological correlation of breast lesions with histopathological findings to evaluate the diagnostic accuracy of sonomammography and FNAC. Material and Methods: A prospective, quantitative and descriptive study was conducted in the department of Radiology, Father Muller Medical College Hospital, Mangalore. Patients who were evaluated for suspicious breast lump with a breast ultrasound, FNAC and biopsy from January 2017 to December 2018 were included in the study. Results: In this study, diagnostic accuracy for breast FNAC (98.7%) was found to be better than that of sonomammography (92.5%). Fine needle aspiration cytology of breast lump plays an important role when it is difficult to determine the nature of breast lump by clinical and radiological examination. In this study breast FNAC was found to have sensitivity of 98.4% and specificity of 95.7%. Sonomammography had a sensitivity of 90.6%and specificity of 97.8. Conclusion: Present study confirms the higher combined sensitivity, specificity and accuracy for ultrasonography and fine needle aspiration cytology in categorisation of breast lump as benign and malignant. USG is better indetection of benign lesions whereas cytology is better in case of malignancies. The triple assessment is an accurate, simple and cost-effective method for the evaluation of breast cancer and can be applied at our centre as a safe alternative for open biopsy when it is concordant and open biopsy must be reserved only for discordant results. This will subsequently reduce the number ofbreast biopsies significantly.

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Section: Discussionsupporting

confidence: 90%

Radiological and Cytological Correlation of Breast Lesions with Histopathological Findings in a Tertiary Care Hospital in Costal Karnataka

Richie¹,

Mellonie²

2019

IJCMR

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“…Out of 10 cases of fibrocystic disease diagnosed on FNAC, 8 were fibrocystic disease on HPE and one case of phyllodes tumour was diagnosed the same on histopathology. 28 In this study, the sensitivity of clinical breast examination and USG in the diagnosis of benign breast lumps was quite good but showed relatively less specificity than FNAC. FNAC showed sensitivity of 97.2% and good specificity.…”

Section: Discussionmentioning

confidence: 87%

Clinical radiological and pathological assessment of benign breast lumps: our institutional experience

2017

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Background: With increased awareness about breast cancer, many women with breast lumps are attending clinics. Though benign breast lumps are most common, they may be associated with morbidity and have become cause for concern to patients. Triple assessment by clinical, radiological and pathological examination is a standard approach in the evaluation of breast lumps. Even in cases of benign breast diseases, multimodality tests are being preferred to give reassurance to patients. This study was aimed to study distribution of various benign breast lumps in relation to age at presentation, to identify sensitivity and specificity of clinical breast examination, Ultrasonography (USG) and Fine needle aspiration cytology (FNAC) methods in the evaluation of benign breast lumps and to compare with final histopathological diagnosis.Methods: A retrospective study was conducted in department of general surgery at Malla Reddy institute of medical sciences, Hyderabad from August 2013 to July 2017. 202 females with benign breast lumps were evaluated by clinical breast examination, ultrasonography (USG) and Fine needle aspiration cytology (FNAC) methods. All patients underwent excision biopsy of lump. Final histopathological report was taken as reference standard.Results: Fibroadenoma was most common in 2nd decade. Clinical breast examination and USG showed good sensitivity but less specificity than FNAC. FNAC showed both good sensitivity and specificity. There was very good degree of agreement between FNAC and histopathological diagnosis (Kappa=0.911).Conclusions: Good clinical examination can give accurate preoperative diagnosis of benign breast lumps. Triple assessment by clinical breast examination, USG and FNAC can be useful in the evaluation of benign breast lumps.

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“…[19] Histopathological examination should be performed for uncertain diagnostic cases and when the evaluation of the invasiveness or histological type of breast lesion is mandatory. [20] The gold standard test used in our study was the histopathological report which is valid, reproducible and has been accepted as the gold standard internationally.…”

Section: Discussionmentioning

confidence: 99%

Comparison Of Diagnostic Accuracy Of BIRADS Score With Pathologic Findings In Breast Lumps

Thomas²,

Hiremath³

et al. 2017

APALM

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Background: Breast lump is one of the commonest complaints with which patients present in breast clinics. As approximately 10% of breast masses ultimately lead to a diagnosis of breast cancer, it is important for women with a breast lump to receive appropriate evaluation. A confident diagnosis can be made in 95% of the cases through a combination of clinical examination, imaging and fine needle aspiration cytology. Histopathology is the gold standard for diagnosis.Methods: This is a prospective study conducted in the Department of Pathology, K.V.G Medical College, Sullia on 50 patients who presented with clinically palpable breast lump. Patients were subjected to sonomammography and Breast Imaging Reporting and Data System (BIRADS) scoring followed by FNAC and histopathological examination. Sensitivity, specificity, accuracy, positive and negative predictive values of sonomammogram in relation to the BIRADS score and FNAC taking histopathology as the gold standard was calculated.Result: FNAC had significantly higher sensitivity, specificity, positive and negative predictive values and accuracy compared to sonographical diagnosis using BIRADS score.Conclusion: FNAC could be considered as the first method to evaluate breast lesions, recognized by means of imaging techniques.

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Cytological evaluation of benign breast lesions with histopathological correlation

Cited by 8 publications

References 0 publications

Radiological and Cytological Correlation of Breast Lesions with Histopathological Findings in a Tertiary Care Hospital in Costal Karnataka

Radiological and Cytological Correlation of Breast Lesions with Histopathological Findings in a Tertiary Care Hospital in Costal Karnataka

Clinical radiological and pathological assessment of benign breast lumps: our institutional experience

Comparison Of Diagnostic Accuracy Of BIRADS Score With Pathologic Findings In Breast Lumps

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