Cytological features of canine ovarian tumours: a retrospective study of 19 cases

Abstract

The cytological features of 19 histologically confirmed canine ovarian tumours were retrospectively examined. Seven cases were cytologically classified as papillary adenocarcinoma, eight cases as granulosa cell tumours, two cases as mature ovarian teratomas, one case as a dysgerminoma and one case as a mixed granulosa cell tumour/dysgerminoma. On cytology, papillary adenocarcinoma was characterised by a papillary glandular pattern and tight cohesiveness. Granulosa cell tumours showed monolayered clusters of loosely cohesive granulosa cells. Call-Exner-like bodies were found in five of seven cases. Granulosa cells appeared to be heterogeneous and usually contained several intracytoplasmic vacuoles. Teratoma was characterised cytologically by keratin debris (two cases) and a mixture of epithelial cells with sebaceous, basaloid, columnar/palisading or ciliated appearance (one case). The dysgerminoma contained severely atypical round cells admixed with small lymphocytes. The mixed dysgerminoma/granulosa cell tumour had a mixture of germinal and granulosa cells. Cytological diagnosis was in agreement with histopathology in 18 of 19 (94.7 per cent) cases.

Teratoma sacrococcígeo neonatal em felino: relato de caso

“…O predomínio de queratinócitos no caso relatado concorda com Bertazzolo et al (2004) que afirmam que, dependendo do local onde for realizada a punção, pode haver predomínio de um único tipo celular.…”

Gonadoblastoma in the Ovaries of a Lesser Galago (Galago senegalensis braccatus)

“…In contrast to GB, MGCSCST in people tends to occur in patients with normal phenotype or karyotype, is frequently unilateral, the sex cordstromal cells exhibit proliferative activity and in general lacks mineralization, extracellular matrix and the distinct histological patterns of GB. Most of the reported cases of GB or MGCSCST in animals, mainly in dogs and horses, occurred in the testes instead of the ovaries (Turk et al, 1981;Bertazzolo et al, 2004;Reis-Filho et al, 2004;Owston and Ramos-Vara, 2007;Talerman and Roth, 2007;Leach et al, 2008;Brito et al, 2009;Ramos-Vara and Miller, 2009). No previous cases of GB or MGCSCST have been reported in the gonads of non-human primates (Lowestine, 1986;Brack, 1988;Moore et al, 2003;Cianciolo et al, 2007;Cooper and Gabrielson, 2007;Wilkinson et al, 2008;Remick et al, 2009).…”

“…Only MGCSCST is included in the WHO classification of tumours of the male genital system in domestic animals (Kennedy et al, 1998). Very few GB or GB-like tumours have been reported in male animals and there is only one report of a mixed dysgerminoma/granulosa cell tumour in the ovary of a dog (Turk et al, 1981;Bertazzolo et al, 2004;Reis-Filho et al, 2004). GB and MGCSCST are thus far unreported in nonhuman primates (Lowestine, 1986;Brack, 1988;Moore et al, 2003;Cianciolo et al, 2007;Cooper and Gabrielson, 2007;Wilkinson et al, 2008;Remick et al, 2009).…”

“…Gonadal tumours composed of a mixture of germinal cells and sex cord-stromal cells occur uncommonly in people and animals (Turk et al, 1981;Bertazzolo et al, 2004;Reis-Filho et al, 2004;Owston and Ramos-Vara, 2007;Talerman and Roth, 2007;Leach et al, 2008;Brito et al, 2009;Ramos-Vara and Miller, 2009). In people, these tumours are subclassified by the World Health Organization (WHO) into gonadoblastoma (GB) and mixed germinal cell-sex cord-stromal tumour (MGCSCST) (Talerman and Roth, 2007).…”

Canine Ovarian Serous Papillary Adenocarcinoma with Neoplastic Hypercalcemia

“…Sci. 68(9): 979-982, 2006 In dogs, the most common epithelial cell tumors of the ovary are papillary adenoma and adenocarcinoma [2,7,10]. In humans, paraneoplastic hypercalcemia is reported to be associated with ovarian tumors [1,4,12,13].…”