Cytopathology of pulmonary lesions: A tertiary care center experience

Ghildiyal, Supriya; Acharya, Seema; Thakur, Brijesh; Rawat, Jagdish; Kumar, Rajnish

doi:10.4103/joc.joc_51_18

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…Among the cases of malignancy confirmed by ENB, only 50% were reported as atypical or malignant cells, which is higher than that reported in a previous study with a sensitivity of 20%. [ 20 ] Although bronchoalveolar lavage was obtained from the target lesion using ENB, this study showed the limited value of cytology tests and obtaining cell block specimen even through ENB.…”

Section: Discussionmentioning

confidence: 97%

Outcomes of the electromagnetic navigation bronchoscopy using forceps for lung lesion suspected malignancy: A retrospective study

Kim,

Kim

et al. 2023

Medicine

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Many studies have reported electromagnetic navigation bronchoscopy (ENB) diagnostic yields and the importance of size and computed tomography (CT) bronchus sign. This study aimed to determine the diagnostic yield of ENB alone, using forceps biopsy and cytology. We analyzed the factors associated with yield and complications according to gross specimen size. This retrospective study included patients who underwent ENB using forceps for suspected lung lesions on CT between January 2020 and December 2022 in South Korea. Factors related to the ENB diagnostic yield and complications were evaluated, and the impacts of gross specimen size and cytology were analyzed. A total of 276 patients were analyzed. The final diagnostic yield was 75.5% after excluding indeterminate cases. Sensitivity and specificity were 74.2% and 100%, respectively. Pneumothorax developed in 1.4% (4/276) of cases, with no grade 3 or higher bleeding. Univariable analysis showed that the number of biopsies and the size of the gross specimen were related to the diagnosis. Multivariable analyses showed that a larger lesion size on CT was a significant factor for diagnosis. The gross size of the specimens was not significantly associated with epinephrine use. ENB had acceptable diagnostic yield and safety for diagnosing lung lesions with suspected malignancy. Obtaining more tissue through biopsy may not increase bleeding or pneumothorax complications. Identifying patients with lesion characteristics, including CT bronchus sign, would help increase ENB diagnostic yield.

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Section: Discussionmentioning

confidence: 97%

Outcomes of the electromagnetic navigation bronchoscopy using forceps for lung lesion suspected malignancy: A retrospective study

Kim,

Kim

et al. 2023

Medicine

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“…and Ghildiyal et al ., which also found that the most common malignancy was adenocarcinoma, followed by squamous cell carcinoma. [ 3 9 ] However, in a study by Raiza et al ., squamous cell carcinoma was the most common malignancy followed by adenocarcinoma. [ 13 ]…”

Section: Discussionmentioning

confidence: 99%

“…also showed that males were more commonly affected than females with a male-to-female ratio of 1.6:1 and 1.9:1, respectively. [ 8 9 ]…”

Section: Discussionmentioning

confidence: 99%

Role of Bronchoscopic Cytology in Diagnosis of Pulmonary Lesions

Kedige¹,

Dinesh²

2023

Journal of Cytology

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Objectives: Respiratory cytology specimens such as bronchoalveolar lavage (BAL) and bronchial wash (BW) obtained using a fiberoptic bronchoscope are very useful in detecting or ruling out various inflammatory conditions, infections, and neoplastic lesions. A study was carried out to determine the usefulness of respiratory cytology in the diagnosis of pulmonary lesions and the limitations of cytology if any, and correlate the results of cytology with biopsies wherever possible. Methods: All bronchoscopic cytology and biopsy specimens received at the pathology laboratory of this tertiary care institute between June 2014 and May 2017 were analyzed. Cytology smears were stained with Leishman's stain, hematoxylin and eosin (H and E), Papanicolaou (PAP), and Ziehl–Neelsen (ZN) stain for all cases and special stains wherever needed. Slides prepared from biopsy specimens were stained with H and E. Immunohistochemistry was used for confirmation and further typing of malignant lesions and diagnosis rendered was compared with the corresponding cytology diagnosis. Results: A total of 120 specimens of BAL or BW cytology with or without biopsy were analyzed. Thirty-three were diagnosed as non-specific inflammatory lesions. The most common malignancy diagnosed by cytology was adenocarcinoma followed by squamous cell carcinoma. Correlating BAL with biopsy specimens, the sensitivity, specificity, and diagnostic accuracy of BAL were 100%, 88.8%, and 91.6%, respectively. Correlating BW with biopsy specimens, the sensitivity, specificity, and diagnostic accuracy of BW were 85.6%, 85.6%, and 85.6%, respectively. Conclusions: Accurate diagnosis can be made from the examination of bronchoscopic cytology specimens in pulmonary inflammation, tuberculosis, fungal infections, and malignancies. Combining respiratory cytology with biopsy and ancillary techniques can aid in better subtyping of neoplastic lesions.

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Fine Needle Aspiration Cytology of the Lung

Dey¹

2020

Color Atlas of Fine Needle Aspiration Cytology

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Cytopathology of pulmonary lesions: A tertiary care center experience

Cited by 6 publications

References 5 publications

Outcomes of the electromagnetic navigation bronchoscopy using forceps for lung lesion suspected malignancy: A retrospective study

Outcomes of the electromagnetic navigation bronchoscopy using forceps for lung lesion suspected malignancy: A retrospective study

Role of Bronchoscopic Cytology in Diagnosis of Pulmonary Lesions

Fine Needle Aspiration Cytology of the Lung

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